Doctoral Researcher (f/m/d) - Recoding Mechanisms in Infections

Code: 197/2022

2022-11-08

Recoding Mechanisms in Infections

The Helmholtz Institute for RNA-based Infection Research (HIRI) is offering a position as Doctoral Researcher (f/m/d) in the Research Group “Recoding Mechanisms in Infections” of Junior Professor Neva Caliskan.

Tasks

Project Title: Investigating the mechanism of translation regulation by the newly discovered frameshift regulatory RNA binding proteins

The Caliskan lab investigates functions and dynamics of RNA molecules in non-canonical translation events, which can affect the interplay between the host and pathogen during infections (Zimmer and Kibe et al, Nature Comm. 2021, Hill, Pekarek et al. Nature Comm. 2021). Current project interests include developing new tools and methods for monitoring translation and RNA:protein dynamics to enable,

  • probing dynamics of RNA-protein complexes at the molecular level
  • single molecule (fluorescence assisted optical tweezers) and ensemble analysis of translation
  • high throughput profiling (Ribo-seq, RNA-seq) to decipher RNP functions during infections

Ultimately, Caliskan lab seek to illuminate therapeutic RNA-protein complexes as novel targets to combat infections.

Project description

The project will characterize novel regulatory RNA binding factors and decipher fine mechanistic details of translational regulation using high resolution techniques. Also CRISPRi, Ribo-seq, RNA-seq and iCLIP might be carried out to investigate protein functions in the global scale. The project will be carried out in a highly international, collegial, collaborative, and interdisciplinary work environment, with a range of possibilities to develop independence and new skills.

Prerequisite

  • Master’s degree/Diploma or equivalent in the field of biochemistry, molecular biology, biophysics or a related field of the life sciences
  • Strong interest and enthusiasm for understanding role of RNA binding proteins in translation
  • Readiness of mind and willingness to familiarize themselves with new techniques
  • Solid understanding of lab techniques and workflows in RNA and protein biochemistry
  • Experience with Python, MatLab or R for data analysis is preferred
  • Previous experience with single molecule techniques, especially optical tweezers or smFRET is an advantage
  • High motivation, problem solving and good organizational skills
  • Ability to work independently and as part of an international team
  • Strong written and spoken English language communication skills
  • Solid understanding of RNA biology, translation mechanisms, and/or analysis of RNP complexes

Disabled persons are given preference in the case of equal professional qualification. The HIRI aims for professional equality between women and men. The position is suitable for part-time work.

Location

HIRI Würzburg

Research Group

Part-Time Suitability

The position is suitable for part-time employment.

Special preference toward women

possible

Starting date

01.02.2023

Contract time limit

3 years

Probation period

6 months

Salary

alike TVöD/ Bund E13 (65%)

Published on

2022-11-08

Applications accepted until  2022-12-15

Applicants are required to complete the online application form here: https://hzi.opencampus.net/ (Please select Job No. 197/2022)

For further information please contact Junior Professor Caliskan, email: neva.caliskan@helmholtz-hiri.de.

About the HIRI

The Helmholtz Institute for RNA-based Infection Research (HIRI) is the first institution of its kind worldwide to combine ribonucleic acid (RNA) research with infection biology. Based on novel findings from our strong basic research program, our long-term goal is to develop innovative therapeutic approaches to better diagnose and treat human infections. HIRI is a site of the Braunschweig Helmholtz Centre for Infection Research (HZI) in cooperation with the Julius-Maximilians-Universität Würzburg (JMU) and is located on the Würzburg Medical Campus.

More information at www.helmholtz-hiri.de.

Did you now?

HZI International Graduate School

The HZI International Graduate School for Infection Research (GS-FIRE) provides an innovative structured PhD programme within the field of Infection Research.

PhD programme “Epidemiology”

The PhD programme “Epidemiology” is a three-year doctoral programme in the area of epidemiological research and is coordinated by the Department of Epidemiology of the HZI.

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