Bachelor- and Master Theses

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2019-10-01

Chemical Biology

The Department of Chemical Biology at the HZI offers to interested and engaged biology-, biochemistry-and biotechnology students on a regular basis: - Internship Positions (max. 3 months) - Bachelor- and Master Theses The centre provides modern laboratories and state-of-the-art instrumentation, various biological profiling platforms, a lively scientific environment and programs for the development of interdisciplinary scientific expertise as well as personal skills, which are ideal prerequisities for a successfull future carrier.

Tasks

Possible topis for biology-, biochemistry- and biotechnology students:

  • Investigation of the mechanism of drug internalization into Gram-negative bacteria by imaging methods, mass spectrometry and microbiological assays
  • Mass spectrometry-based investigations of the bacterial metabolome, with emphasis on the influence of drugs on virulence factors
  • Elucidation of the molecular targets and the cellular mode of action of active compounds
  • Development of phenotypic cell based assays for the investigation of infection-relevant processes
  • Identification of active compounds by automated screening of compound libraries

Possible topis for (synthetic) chemists:

  • Natural product-based as well as synthetic lead structures with promising activities against Gram-positive and Gram-negative bacteria are structurally optimized by semi- or total synthesis. The biological properties of the molecules are characterized within the department, next door to the chemist.
  • Molecular Trojan horses: Antimicrobial compounds are conjugated chemically with structures that are actively taken up by bacteria (e.g. via iron or sugar transport systems).
  • Drug-based probes for the investigation of biological processes are synthesized and utilized for imaging applications, target identification or as photo switches.
  • Analytical chemistry projects dealing with mass spectrometry-based studies of the metabolome of pathogenic bacteria.

Location

Headquarter Braunschweig

Research Group

Starting date

jederzeit

Published on

2019-10-01

Further information about the institute and our department can be obtained via the internet at www.helmholtz-hzi.de. If you are interested please get in touch with Prof. Dr. Mark Brönstrup, mark.broenstrup@helmholtz-hzi.de.

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