Bachelor- and Master Theses

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Chemical Biology

The Department of Chemical Biology at the HZI offers to interested and engaged chemistry, pharmacy, biology, biochemistry and biotechnology students on a regular basis: - Internship Positions (max. 3 months) - Bachelor- and Master Theses The centre provides modern laboratories and state-of-the-art instrumentation, various biological profiling platforms, a lively scientific environment and programs for the development of interdisciplinary scientific expertise as well as personal skills, which are ideal prerequisities for a successfull future carrier.


Possible topis for biology-, biochemistry- and biotechnology students:

  • Investigation of the mechanism of drug internalization into Gram-negative bacteria by imaging methods, mass spectrometry and microbiological assays
  • Mass spectrometry-based investigations of the bacterial metabolome, with emphasis on the influence of drugs on virulence factors
  • Elucidation of the molecular targets and the cellular mode of action of active compounds
  • Development of phenotypic cell based assays for the investigation of infection-relevant processes
  • Identification of active compounds by automated screening of compound libraries

Possible topis for (synthetic) chemists:

  • Natural product-based as well as synthetic lead structures with promising activities against Gram-positive and Gram-negative bacteria are structurally optimized by semi- or total synthesis. The biological properties of the molecules are characterized within the department, next door to the chemist.
  • Molecular Trojan horses: Antimicrobial compounds are conjugated chemically with structures that are actively taken up by bacteria (e.g. via iron or sugar transport systems).
  • Drug-based probes for the investigation of biological processes are synthesized and utilized for imaging applications, target identification or as photo switches.
  • Analytical chemistry projects dealing with mass spectrometry-based studies of the metabolome of pathogenic bacteria.


Headquarter Braunschweig

Research Group

Starting date


Published on


Further information about the institute and our department can be obtained via the internet at If you are interested please get in touch with Prof. Dr. Mark Brönstrup,

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