Alumni - PhD Students 2007

Imke Bargen

Research Topic: Establishment of a murine infection model for Mycobacterium paratuberculosis

Supervisor: Dr. Siegfried Weiß, Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig

Academic Background: Biology, Technical University Braunschweig, Germany

Nationality: German

Paulina Blazejewska

Research Topic: Genetic susceptibility in mammals to influenza infection

Supervisor: Prof. Dr. Klaus Schughart, Experimental Mouse Genetics, Helmholtz Centre for Infection Research, Braunschweig

Academic background: Biotechnology, Adam Mickiewicz University Poznan, Poland

Nationality: Polish

Publication:

B. Srivastava, P. Blazejewska, M. Heßmann, D. Bruder, R. Geffers, S. Mauel, A. D. Gruber and K. Schughart (2009). The genetic background of the host strongly influences the response to influenza A virus infections in mice. PLoSONE 2009.

 

 

Christiane Brohm

Research Topic: Molecular Interactions in the course of hepatitis C virus assembly

Supervisor: Prof. Dr. Thomas Pietschmann, Department for Experimental Virology, Twincore Center, Hannover

Academic Background: Biology, Ruprechts-Karls-University, Heidelberg, Germany

Nationality: German

Publications:

Brohm, C., Steinmann, E., Friesland, M., Lorenz, IC, Patel, A., Penin, F., Bartenschlager, R., and T. Pietschmann (2009). Characterization of determinants important for hepatitis C virus p7 function in morphogenesis by using trans-complementation. J Virol. 83: 11682-93.

E. Steinmann, C. Brohm, S., R. Bartenschlager, and Thomas Pietschmann. Efficient trans-Encapsidation of Hepatitis C Virus RNA into Infectious Virus-Like Particles. J Virol. 2008 July; 82(14): 7034-7046.

Awards:

3. Prize (Poster) Summer School on Infection Biology, May 18-23, 2008, Quedlinburg.

1. Prize (oral presentation) HIRSIB Retreat Class of 2007, 30th Oct. 2008, Braunschweig.

 

 

Tamás Dolowschiák

Research Topic: The Role of Polarisation and Horizontal Communication during Proinflammatory Stimulation of Epithelial Cells

Supervisor: Prof. Dr. Mathias Hornef, Department of Medical Microbiology and Hospital Epidemiology, Hannover Medical School

Academic Background: Biology, University of Pecs, Hungary

Nationality: Hungarian

 

Ines Hahn

Research Topic: Role of phosphoinositide 3-kinase g in the pulmonary host defense against Streptococcus pneumoniae infections

Supervisor: PD Dr. Ulrich Maus, Experimental Pneumology, Hannover Medical School

Academic Background: Biotechnology, Technical University Braunschweig, Germany

Nationality: German

 

Wiebke Jäger

Research Topic: The role of USP7 during KSHV latency

Supervisor: Prof. Dr. Thomas Schulz, Department of Virology, Hannover Medical School

Academic Background: Microbiology, Technical University Braunschweig, Germany

Nationality: German

Anja Marquardt

Research Topic: In vivo monitoring of MCMV-mutants provoking an altered immune response

Supervisor: Prof. Dr. Martin Messerle, Virology, Hannover Medical School

Academic Background: Biology, Technical University Braunschweig, Germany

Nationality: German

Publication:

Busche A, Marquardt A, Bleich A, Ghazal P, Angulo A, Messerle M. The mouse cytomegalovirus immediate-early 1 gene is not required for establishment of latency or for reactivation in the lungs. J Virol. 2009 May; 83(9): 4030-8. Epub 2009 Feb 11.

 

Julia Schneider

Research Topic: Structure-based design of specific inhibitors for Apicomplexa myosins

Supervisor: Prof. Dr. Dietmar Manstein, Institute for Biophysical Chemistry, Hannover Medical School

Academic Background: Biochemistry, University of Greifswald, Germany

Nationality: German

 

Evgeniya Solodova

Research Topic: Role of type I interferons in the innate and adaptive immune defense against Gram-negative bacteria

Supervisor: Dr. Siegfried Weiß, Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig

Academic Background: Natural Sciences, Novosibirsk State University

Nationality: Russian

 

Barkha Srivastava

Research Topic: Immunogenetics of the host response to Influenza A infection

Supervisor: Prof. Dr. Klaus Schughart, Experimental Mouse Genetics, Helmholtz Centre for Infection Research, Braunschweig

Academic Background: Biotechnology, Barkatullah University Bhopal, India and Parasitology, McGill University, Montreal, Canada

Nationality: Indian

 

Imke Steffen

Research Topic: Signal sequence of HIV-1 glycoprotein: A determinant of posttranslational processing, folding and function?

Supervisor: Prof. Dr. Stefan Pöhlmann, Virology, Hannover Medical School

Academic Background: Biochemistry, Ruhr-University, Bochum, Germany

Nationality: German

Publications:

Chaipan C, Kobasa D, Bertram S, Glowacka I, Steffen I, Tsegaye TS, Takeda M, Bugge TH, Kim S, Park Y, Marzi A, Pöhlmann S. Proteolytic activation of the 1918 influenza virus hemagglutinin. J Virol. 2009 Apr; 83(7): 3200-11.

Glowacka I, Bertram S, Herzog P, Pfefferle S, Steffen I, Muench MO, Simmons G, Hofmann H, Kuri T, Weber F, Eichler J, Drosten C, Pöhlmann S. Differential downregulation of ACE2 by the spike proteins of SARS-coronavirus and human coronavirus NL63. J Virol. 2009 Oct 28. [Epub ahead of print].

Kühl A, Münch J, Sauter D, Bertram S, Glowacka I, Steffen I, Specht A, Hofmann H, Schneider H, Behrens G, Pöhlmann S. No evidence for a restriction of retrovirus release by calcium-modulating cyclophilin ligand. Nat. Med. [accepted].

Awards: 

Young Investigator Award, Conference on Retroviruses and Opportunistic Infections 2009.

Poster Prize, 1st Master Class of Virology, 12. - 14.11.09, Twincore, Hannover.

 

 

Benjamin Wahl

Research Topic: Assessing oral tolerance on the basis of T cell migratory routes

Supervisor: Prof. Dr. Oliver Pabst, Institute of Immunology, Hannover Medical School

Academic Background: Biochemistry, Leibniz University Hannover, Germany

Nationality: German

Publications:

Pabst O, Wahl B, Bernhardt G, Hammerschmidt SI. Mesenteric lymph node stroma cells in the generation of intestinal immune responses. J Mol Med. 2009 Oct; 87(10): 945-51.

Carlens J, Wahl B, Ballmaier M, Bulfone-Paus S, Förster R, Pabst O. Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestine. J Immunol. 2009 Nov 1; 183(9): 5600-7.

Hammerschmidt SI, Ahrendt M, Bode U, Wahl B, Kremmer E, Förster R, Pabst O. Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo. J Exp Med. Oct 2008.

Award:

3rd place at the retreat October 2007 at the HZI Braunschweig.

 

Jörg Willenborg

Research Topic: CcpA and ArgR: Two different strategies to control virulence gene expression in Streptococcus suis

Supervisor: Prof. Dr. Peter Valentin-Weigand, Institute of Microbiology, University of Veterinary Science Foundation Hannover

Academic Background: Plant Biotechnology, Leibniz University Hannover , Germany

Nationality: German

Publications:

Willenborg1, J., Fulde1, M., de Greeff, A., Benga, L., Smith, HE., Valentin-Weigand, P., Goethe, R (2011). ArgR is an essential local transcriptional regulator of the arcABC-operon in Streptococcus suis and crucial for biological fitness in acidic environment. Microbiology 157, 572-582.
1contributed equally

Willenborg, J., Fulde, M., de Greeff, A., Rohde, M., Smith, HE., Valentin-Weigand, P., Goethe, R. (2011). Role of glucose and CcpA in capsule expression and virulence of Streptococcus suis. Microbiology (in press, 2011) doi:10.1099/mic.0.046417-0.

Award:

HIRSIB prize (at final defense of the PhD Thesis)

 

Kontakt

Dr. Sabine Kirchhoff

GS-FIRE (HZI International Graduate School for Infection Research)

Helmholtz Zentrum für Infektionsforschung
Inhoffenstraße 7
38124 Braunschweig

hzigrad.school@helmholtz-hzi.de