DDOP / DDEL
The range of scientific activities at the Helmholtz Institute for Pharmaceutical Research Saarland/ HIPS comprises genetic and genome-analytic methods for optimizing natural product producers and lead compounds as well as methodologies to improve the transportation of pharmaceutical agents to their target. The combination of the knowledge on infectious diseases and the pharmaceutical research of Helmholtz Centre for Infection Research/ HZI and HIPS take a unique position in Germany and Europe, especially regarding the development of anti-infectives. The complementary expertise allows concerted and synchronous approaches to the discovery and mining of novel producers of potential drugs, their rational improvement and bioprofiling, as well as their optimal formulation. This greatly enhances the chance of identifying and utilizing novel natural products and accelerates their advancement to clinical studies. The combined research activities and experiences of the scientists at HIPS, HZI and further regional cooperation institutes in drug development allow for the complete coverage in drug development from drug discovery to clinical phase IIa studies. A successful implementation of translational research is thus achieved. The Departments for Drug Design and Optimization (DDOP) and Drug Delivery (DDEL), headed by Prof. Anna Hirsch and Prof. Claus-Michael Lehr, resp., are jointly looking for a Postdoctoral Researcher to work on an interdisciplinary project at the scientific interface of these two research areas. Biodynamers are biodegradable polymers, capable to dynamically respond to external stimuli by adapting their structure and function. The project aims to design tailored biodynamers for improving the delivery of different anti-infectives, including small molecules as well as nucleotides, across relevant biological barriers, such as epithelial tissues, mammalian as well as bacterial cell membranes. The practical work comprises the synthesis and physico-chemical characterization, the explorative formulation of nanocarriers, as well as their bio-pharmaceutical evaluation in advanced cell and tissue models. We offer an inspiring research environment with excellent facilities as needed for both the chemical and biopharmaceutical aspects of the project. The interdisciplinary team of scientists at the HIPS is well integrated in international networks as needed for cutting-edge infection research and thus provides many opportunities for scientific exchange and creation of own ideas. We are looking for a researcher with experience in chemical synthesis, but highly motivated to explore the field of drug delivery and biopharmaceutics. A background in polymer chemistry, biochemical engineering or biomaterials would be an added benefit. The ideal candidate is motivated to bring in own expertise and ideas and is eager to learn complementary methods. A communicative, open person will profit from the bridging between the two departments. We consider a significant publication record, the motivation for independent research, but also for team work as key qualifications. Qualifications: PhD in Medicinal/Pharmaceutical/Polymer Chemistry or a related subject. Preference is given to severely disabled persons with the same professional qualifications. Equal Opportunities are part of our personnel policy. Part-time employment is possible upon request
- Wirkstoff-Transport - Prof. Dr. Claus-Michael Lehr
- Wirkstoffdesign und Optimierung - Prof. Dr. Hirsch / Prof. Dr. Hartmann
1 March 2019 / earliest possible starting date
E 13 TVöD/Bund
Bewerbungsschluss ist der 06.01.2019
Please send your complete application with reference to code number 83/2018 to: Helmholtz-Zentrum für Infektionsforschung, Personalabteilung, Inhoffenstraße 7, 38124 Braunschweig or in one (1) single pdf document per mail JobsHZI@helmholtz-hzi.de.
For further information, please contact
Prof. Dr. Anna Hirsch, Anna.Hirsch@helmholtz-hips.de, phone: +49 681 98806 2100
Prof. Dr. Claus-Michael Lehr, Claus-Michael.Lehr@helmholtz-hips.de, phone: +49 681 98806 1000
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Die HZI International Graduate School for Infection Research (GS-FIRE) bietet ein innovatives, strukturiertes Promotionsprogramm im Themenbereich "Infektionsforschung".