Alumni - PhD Students 2006

Nicole Dietrich

Research Topic: Signal Induction in Host Cells by Listeriolysin the Cholesterol Dependent Cytolysin of Listeria monocytogens - Consequences of Ca 2+ Mobilisation

Supervisor: Dr. Siegfried Weiß, Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig

Academic Background: Biology, Technical University Braunschweig, Germany

Nationality: German

Publications:

Leschner S, Westphal K, Dietrich N, Viegas N, Jablonska J, Lyszkiewicz M, Lienenklaus S, Falk W, Gekara N, Loessner H, Weiss S. Tumor invasion of Salmonella enterica serovar Typhimurium is accompanied by strong hemorrage promoted by TNF-alpha. Plos One. 2009 Aug 20; 4(8): e6692.

Gekara NO, Dietrich N, Lyszkiewicz M, Lienenklaus S, Weiss S. Signals triggered by a bacterial pore-forming toxin contribute to toll-like receptor redundancy in gram-positive bacterial recognition. J Infect Dis. 2009 Jan 1; 199(1): 124-33.

Dietrich N, Lienenklaus S, Weiss S, Gekara NO. Toll-like receptor 2 activation induces IRF1 and IRF7 dependent type I interferon responses from endolysosomal compartments. Under revision in Plos Biology.

Dietrich N, Rohde M, Geffers R, Kroeger A, Hauser H, Weiss S, Gekara NOIn response to bacteria, mast cells mount pro-inflammatory but not type I interferon responses due to the inability to internalize TLR bound ligands. Under revision in PNAS.

Awards:

Förderpreis des Arbeitskreises für Zellbiologie und Biomedizinische Forschung e.V. 2009.

1st Presentation Price PhD program Infection Biology, Retreat 12.02.2009.

 

 

Sirine El Houry

Research Topic: The DNA Polymerase III Holoenzyme of Pseudomonas aeruginosa

Supervisor: Dr. Ute Curth, Institute for Biophsical Chemistry, Hannover Medical School

Academic Background: Molecular and Cell Biology (MSc), Pasteur Institute, Paris, France & Biology (BSc), American University of Beirut, Lebanon

Nationality: Lebanese

Award: 2007 HIRSIB Retreat, 1st price

 

 

 

Swantje Hammerschmidt

Research Topic: Elucidating the Role of Intestinal Plasmacytoid Dendritic Cells During Infection and Inflammation

Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School

Academic Background: Biochemistry, Leibniz University Hannover, Germany

Nationality: German

Publication:

Pabst O, Wahl B, Bernhardt G, Hammerschmidt SI. Mesenteric lymph node stroma cells in the generation of intestinal immune responses. J Mol Med. 2009 Oct; 87(10): 945-51.

Hammerschmidt SI, Ahrendt M, Bode U, Wahl B, Kremmer E, Förster R, Pabst O. Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo. J Exp Med. 2008 Oct 27; 205(11): 2483-90. Epub 2008 Oct 13.

Ahrendt M, Hammerschmidt SI, Pabst O, Pabst R, Bode U. Stromal cells confer lymph node-specific properties by shaping a unique microenvironment influencing local immune responses. J Immunol. 2008 Aug 1; 181(3): 1898-907.

Award: Poster Price, RCAI International Summer Programm 2009, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan.

 

 

Jan Hänisch

Research Topic: Signal Dependent Activation of Actin-Polymerisation During Salmonella Invasion

Supervisor: Dr. Theresia Stradal, Signalling and Motility Group, Helmholtz Centre for Infection Research, Braunschweig

Academic Background: Biotechnology, University of Münster, Germany

Nationality: German

Publications: 

Hänisch, J., Ehinger, J., Ladwein, M., Rohde, M., Derivery, E., Bosse, T., Steffen, A., Bumann, D., Misselwitz, B., Hardt, W.D., Gautreau, A., Stradal, T.E.B. and Rottner, K. (2009). Molecular dissection of Salmonella-induced membrane ruffling versus invasion. Cell Microbiol [in press].

Block, J., Stradal, T.E.B., Hänisch, J., Geffers, R., Köstler, S., Urban, E., Small, J.V., Rottner, K., Faix J. (2008). Filopodia formation induced by active mDia2/Drf3. J Microsc. 231 (3), 506-17.

Awards: 

1st prize for talk at retreat of post graduate program in 2009.

2nd prize for talk at retreat of post graduate program in 2008.

4th prize for poster at summer school “Infection Biology” in 2008.

 

Anika Hävemeier

Research Topic: The role of KSHV K15 in B cell maturation

Supervisor: Prof. Dr. Thomas Schulz, Department of Virology, Hannover Medical School

Academic Background: Biology, Leibniz University Hannover, Germany

Nationality: German

Publication:

L. Wang, M. Pietrek, M. M. Brinkmann, A. Hävemeier, I. Fischer, B. Hillenbrand, O. Dittrich-Breiholz, M. Kracht , S. Chanas, D. J. Blackbourn and T. F. Schulz. Identification and Functional Characterization 1 of a spliced Rhesus Rhadinovirus gene with homology to the K15 gene of Kaposi’s Sarcoma-associated Herpesvirus. J Gen Virol 90 (2009), 1190-1201.

 

Sonja Horatzek

Research Topic: Key targets of virulence of Pseudomonas aeruginosa TBCF10839: focus on metabolic control

Supervisor: Prof. Dr. Burkhard Tümmler & Dr. Lutz Wiehlmann, Clinical Research Group, Molecular Pathology, Hannover Medical School

Academic Background: Biology, Technical University Braunschweig, Germany

Nationality: German

Publication:

Bohn YT, Brandes G, Rakhimova E, Horatzek S, Salunkhe P, Munder A, van Barneveld A, Jordan D, Bredenbruch F, Häußler S, Riedel K, Eberl L, Østrup Jensen P, Bjarnsholt T, Moser C, Hoiby N, Tümmler B and Wiehlmann L. Multiple roles of Pseudomonas aeruginosa TBCF10839 PilY1 in motility, transport and infection. Mol Microbiol. Dec 2008.

 

Florian Klauschies

Research Topic: Infection of the respiratory epithelium by Canine distemper virus: importance of lipid rafts for virus entry and exit

Supervisor: Prof. Dr. Georg Herrler & Prof. Dr. Ludwig Haas, Institute for Virology, University of Veterinary Medicine Hannover, Foundation

Academic Background: Biology, J.W. Goethe University Frankfurt, Germany

Nationality: German

Publications:

Verweij MC, Koppers-Lalic D, Loch S, Klauschies F, de la Salle H, Quinten E, Lehner PJ, Mulder A, Knittler MR, Tampé R, Koch J, Ressing ME, Wiertz EJ (2008). The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex. J Immunol 181: 4894-907.

Loch S, Klauschies F, Schölz C, Verweij MC, Wiertz EJ, Koch J, Tampé R (2008). Signaling of a varicelloviral factor across the endoplasmic reticulum membrane induces destruction of the peptide-loading complex and immune evasion. J Biol Chem. 283: 13428-36.

 

Rajesh Kolli

Project: Analyses of Hepatitis C Virus-Host Cell Interactions by Live Cell Microscopy

Supervisor: Dr. Benno Woelk, Dept . of Virology, Hannover Medical School

Academic Background: Biotechnology (M. Tech), Jawaharlal Nehru Technological University, India & Pharmacy (B. Pharm), V. Bharati College of Pharmaceutical Sciences, India

Nationality: Indian

 

Zofia Magnowska

Research Topic: Identification and Profiling of Antigens from Pseudomonas aeruginosa in Clinical Isolates of CF Patients by State-of-the-Art Immunoproteomics

Supervisor: Prof. Dr. Jürgen Wehland & Dr. Lothar Jänsch, Cell Biology & Immunology, Helmholtz Centre for Infection Research, Braunschweig

Academic Background: Biotechnology, Jagiellonian University, Cracow, Poland & Environmental Engineering, AGH University of Science and Technology, Cracow, Poland

Nationality: Polish

Publications:

Dötsch A, Becker T, Pommerenke C, Magnowska Z, Jänsch L, Häussler S. Genomewide identification of genetic determinants of antimicrobial drug resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2009 Jun; 53(6): 2522-31

 

Manju Nagarajan

research Topic: Molecular Aspects for the Control of Immune Surveillance by Blood-borne Sphingosine 1-Phosphate (S1P)

Supervisor: Dr. Markus Gräler, Institute of Immunology, Hannover Medical School

Academic Background: Genomics (MSc), Madurai Kamaraj University, India & Biochemistry/Biotechnology (BSc), Bharathiyar University, India

Nationality: Indian

 

Miriam Nörder

Research Topic: Development of Mice Containing the Human Immune System and/or Human Liver for the Preclinical Validation of Vaccine Candidates

Supervisor: Prof. Dr. Carlos Guzmán, Department of Vaccinology, Helmholtz Centre for Infection Research, Braunschweig

Academic Background: Biology, Carl-von-Ossietzky-University Oldenburg, Germany

Nationality: German

 

Ulfert Rand

Research Topic: Monitoring the IFN Response upon Infection

Supervisor: Dr. Hansjörg Hauser, Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig

Academic Background: Biology, Carl-von-Ossietzky-University Oldenburg, Germany

Nationality: German

Award: Best Presentation Award (International Christmas Retreat 2007).

 

Anchana Rathinasamy

Research Topic: Sphingosine-1 Phosphate - a Novel Regulator of Dendritic Cell Traffic and Positioning During the Course of Infection

Supervisor: Prof. Dr. Oliver Pabst, Institute of Immunology, Hannover Medical School

Academic Background: Biotechnology (MSc) University of Madras, India & Microbiology (BSc) Bharathidasan University, India

Nationality: Indian

 

Fabienne Rehren

Research Topic: Inhibition of the Coxackievirus B3 induced Cytokine Expression by Interleukin 1 Receptor Antagonist

Supervisor: PD Dr. med. Albert Heim, Dept. of Virology, Hannover Medical School

Academic Background: Biochemistry, Leibniz University Hannover, Germany

Nationality: German

Publications:

S. Hofmayer, I. Madisch, S. Darr, F. Rehren, A Heim. Unique sequence features of the Human Adenovirus 31 complete genomic sequence are conserved in clinical isolates. BMC Genomics 2009, 10: 557.

S. Darr, I. Madisch, S. Hofmayer, F. Rehren, A. Heim. Phylogeny and primary structure analysis of fiber shafts of all human adenovirus types for rational design of adenoviral gene therapy vectors. Journal of General Virology 2009, 90: 2849-2854.

U. Dierssen, F. Rehren, C. Henke-Gendo, G. Harste, A. Heim. Rapid routine detection of enterovirus RNA in cerebrospinal fluid by a one-step real-time RT-PCR assay. Journal of Clinical Virology, Epub ahead of print 26.12.07.

 

Rachel Thomas

Research Project: Genetic susceptibility factors associated with HIV-1 disease progession and CMV reactivation in co-infected patients

Supervisor: Prof. Dr. Thorsten Witte, Dept. of Clinical Immunology, Hannover Medical School

Academic Background: Environmental Technology and Management (MSc), De Montfort University, England & Biological Sciences (BSc), University of Guelph, Canada

Nationality: British and Canadian

Publications:

Kabalak G, Thomas R, Martin J, Ortego-Centeno N, Jimenez-Alonso J, de Ramón E, Buyny S, Hamsen S, Gross WL, Schnarr S, Zeidler H, Gromnica-Ihle E, Schmidt RE, Witte T.  Association of an NKG2D gene variant with systemic lupus erythematosus in two populations. Hum Immunol. 2009 Sep 6 [Epub ahead of print].

Thomas R, Matthias T, Witte T. Leukocyte immunoglobulin-like receptors as new players in autoimmunity. Clin Rev Allergy Immunol. 2009 Jun 23 [Epub ahead of print].

 

 

Kontakt

Dr. Sabine Kirchhoff

GS-FIRE (HZI International Graduate School for Infection Research)

Helmholtz Zentrum für Infektionsforschung
Inhoffenstraße 7
38124 Braunschweig

hzigrad.school@helmholtz-hzi.de