Compound Profiling und Screening

Die Ausbreitung von Mikroorganismen, die resistent gegen gebräuchliche Antibiotika sind, wird auch von der Weltgesundheitsorganisation (WHO) als zunehmende Bedrohung betrachtet, da dadurch nicht nur die Zahl der Patienten steigt, die bei einer Infektion nicht mehr behandelt werden können, sondern unter Umständen auch andere schwere Krankheiten nicht mehr therapiert werden, wenn die Therapie mit einer Schwächung des Immunsystems und damit einem erhöhten Infektionsrisiko verbunden ist. Aus diesem Grund sind neue Wirkstoffe zur Bekämpfung von Infektionskrankheiten dringend notwendig, genauso wie ein verantwortungsvoller Einsatz der existierenden Antibiotika. Voraussetzung für neue Wirkstoffe sind geeignete Tests zur Erkennung aktiver Substanzen und Substanzbibliotheken ausreichender chemischer Diversität. Neben den Primärscreens führen wir zusammen mit Partnern auch Folgeuntersuchungen durch, die zur Optimierung der Substanz führen sollen.

Leitung

Team

Prof. Dr. Ursula Bilitewski

Leiterin der Arbeitsgruppe Compound Profiling und Screening

Lebenslauf

Education and Employments

* 1977 – 1983   

Chemistry; University of Münster

* Oct. 1983       

Diploma: Dipl.-Chem.

* 1983 – 1987   

Ph.D. thesis at the Institute of Physical Chemistry, University of Münster

* 1987 - 1988   

Postdoctoral fellow, Institute of Physical Chemistry, University of Münster

* Feb. 1987  

Doctorate

* since 1988      

Project manager at the GBF mbH, Braunschweig

* 1994               

Habilitation in Biochemistry at the Technical University of Braunschweig

* since 1994      

Professor for Biochemistry at the Technical University of Braunschweig

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Accomplishments

* since 2000       

Chair of the Working group “Biochemical Methods” of the Waterchemical Society of the GDCh

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Research Interests and Achievements

Ursula Bilitewski has many years of experience in bioanalytical methods. She has started with the development of enzyme electrodes based on screen-printing technology, which is nowadays one of the most frequently used technologies for the industrial production of glucose test strips. This work was complemented by the development of optical affinity sensors using antibodies, receptors and oligonucleotides as binding molecules. Besides the development of suitable surface and immobilisation chemistries, demonstrators and miniaturised systems for the application to food, environmental and bioprocess analysis she became interested in the biological sensing mechanisms and corresponding signal transduction mechanisms.

This led to projects on the elucidation of molecular mechanisms of potential therapeutic or toxic agents, which is now the major focus of her research. Test organisms, such as bacteria, fungi or human or animal cell lines, are treated with the compounds under investigation and the response of the organism is analysed on a molecular level, considering metabolites, proteins and nucleic acids using specific enzyme or immunoassays, gel electrophoresis and DNA-chips. These investigations will be supported by analysis of the dynamics of the intracellular networks using methods of systems biology and lead not only to a molecular understanding of toxic or therapeutic mechanisms but also to new screening assays, as new markers for the activity of compounds will be identified.      

Since her habilitation Prof. Bilitewski was main supervisor of more than 20 PhD students. She is principal author of approx. 70 original publications and 40 review articles.

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