Compound Profiling und Screening

Jeder Mensch trägt viele Mikroorganismen auf und in sich. Sie verwandeln sich von harmlosen Keimen in lebensbedrohliche Pathogene, wenn zum Beispiel als Folge der Therapie einer schweren Krankheit das Immunsystem geschwächt ist. Da entsprechende therapeutische Maßnahmen häufiger werden, nimmt auch die Zahl der Risikopatienten zu. Ihnen werden oft prophylaktisch Antibiotika gegeben, was die Ausbreitung von Resistenzen begünstigt. Daher sind neue therapeutische Ansätze dringend erforderlich.

Publikationen

  • Cui,S.; Hassan,R.Y.; Heintz-Buschart,A.; Bilitewski,U.; (2016). Regulation of Candida albicans Interaction with Macrophages through the Activation of HOG Pathway by Genistein. 21 2 DOI: 10.3390/molecules21020162. PubMed
  • Bruckner,S.; Bilitewski,U.; Schobert,R.; (2016). Synthesis and Antibacterial Activity of Four Stereoisomers of the Spider-Pathogenic Fungus Metabolite Torrubiellone D. Organic Letters: 18 5, 1136-1139 PubMed
  • Kaba,Hani E.J.; Maier,N.; Schliebe-Ohler,N.; Mayer,Y.; Müller,Peter P.; van den Heuvel,Joop; Schuchhardt,J.; Hanack,K.; Bilitewski,Ursula; (2015). Identification of whole pathogenic cells by monoclonal antibodies generated against a specific peptide from an immunogenic cell wall protein. Journal of Microbiological Methods: 108, 61-6901677012 WEBURLS
  • Khodari,M.; Bilitewski,U.; Basry,A.A.H.; (2015). Screen-Printed Electrodes for Amperometric Determination of Iodide. Electroanalysis: 27 2, 281-28410400397 WEBURLS
  • Kaba,H.E.J.; Pölderl,A.; Bilitewski,U.; (2015). Short Peptides Allowing Preferential Detection of Candida albicans Hyphae. 87 17, 8629-863300032700 WEBURLS
  • Kempf,K.; Schmitt,F.; Bilitewski,U.; Schobert,R.; (2015). Synthesis, stereochemical assignment, and bioactivity of the Penicillium metabolites penicillenols B<inf>1</inf> and B<inf>2</inf>. Tetrahedron: 71 31, 5064-506800404020 WEBURLS
  • Cui,S.; Bilitewski,Ursula; (2014). [Effect of genistein on the TLR and MAPK transduction cascades in lipopolysaccharide -stimulated macrophages]. 30 3, 233-236 PubMed
  • El-Mowafy,Mohammed; Bahgat,M.M.; Bilitewski,Ursula; (2013). Deletion of the HAMP domains from the histidine kinase CaNik1p of Candida albicans or treatment with fungicides activates the MAP kinase Hog1p in S. cerevisiae transformants. BMC Microbiology: 13 1, 20914712180 WEBURLS
  • Hassan,R.Y.A.; Bilitewski,Ursula; (2013). Direct electrochemical determination of Candida albicans activity. Biosensors and Bioelectronics: 49, 192-19809565663 DOI: 10.1016/j.bios.2013.05.015 HZI-Repositorium PubMed
  • Cui,S.; Wienhoefer,N.; Bilitewski,Ursula; (2013). Genistein induces morphology change and G2/M cell cycle arrest by inducing p38 MAPK activation in macrophages. International Immunopharmacology: 18 1, 142-150
  • Heintz-Buschart,A.; Eickhoff,H.; Hohn,E.; Bilitewski,Ursula; (2013). Identification of inhibitors of yeast-to-hyphae transition in Candida albicans by a reporter screening assay. Journal of Biotechnology: 164 1, 137-14201681656 DOI: 10.1016/j.jbiotec.2012.12.004 HZI-Repositorium PubMed
  • Cui,Shuna; Qian,J.; Bo,P.; (2013). Inhibitive effect on phagocytosis of Candida albicans induced by pretreatment with quercetin via actin cytoskeleton interference. Journal of Traditional Chinese Medicine: 33 6, 804-80902552922 WEBURLS
  • Kaba,H.E.; Nimtz,Manfred; Müller,Peter P.; Bilitewski,Ursula; (2013). Involvement of the mitogen activated protein kinase Hog1p in the response of Candida albicans to iron availability. BMC Microbiology: 13, 16 PubMed
  • Buschart,A.; Gremmer,K.; El-Mowafy,M.; van den Heuvel,Joop; Müller,Peter P.; Bilitewski,Ursula; (2012). A novel functional assay for fungal histidine kinases group III reveals the role of HAMP domains for fungicide sensitivity. Journal of Biotechnology: 157 1, 268-277 PubMed
  • Buschart,A.; Burakowska,A.; Bilitewski,Ursula; (2012). The fungicide fludioxonil antagonizes fluconazole activity in the human fungal pathogen Candida albicans. Journal of Medical Microbiology: 61 Pt 12, 1696-1703 DOI: 10.1099/jmm.0.050963-0 HZI-Repositorium PubMed
  • Hassan,R.Y.; Bilitewski,Ursula*; (2011). A viability assay for Candida albicans based on the electron transfer mediator 2,6-dichlorophenolindophenol. Analytical biochemistry: 419 1, 26-32 DOI: 10.1016/j.ab.2011.07.025 HZI-Repositorium PubMed
  • Koutinas,M.; Kiparissides,A.; Lam,M.-C.; Silva-Rocha,R.; Godinho,Miguel*; de Lorenzo,V.; Martins dos Santos,V.A.P.; Pistikopoulos,E.N.; Mantalaris,A.; (2011). Improving the prediction of Pseudomonas putida mt-2 growth kinetics with the use of a gene expression regulation model of the TOL plasmid. Biochemical Engineering Journal: 55 2, 108-118 DOI: 10.1016/j.bej.2011.03.012 HZI-Repositorium PubMed
  • Wesolowski,J; Hassan,R.Y.A.; Reinhardt,K.; Hodde,S.; Bilitewski,Ursula*; (2010). Antifungal compounds redirect metabolic pathways in yeasts: Metabolites as indicators of modes of action. Journal of Applied Microbiology: 108 2, 462-471
  • Klippel,N.; Cui,S.; Groebe,L.; Bilitewski,Ursula*; (2010). Deletion of the Candida albicans histidine kinase gene CHK1 improves recognition by phagocytes through an increased exposure of cell wall beta-1,3-glucans. Microbiology: 156 Pt 11, 3432-3444 PubMed
  • Bilitewski,Ursula*; (2009). DNA microarrays: an introduction to the technology.: Microchip Methods in Diagnostics. Bilitewski,Ursula; (Ed.)., 1-14
  • Probst-Kepper,M.; Geffers,Robert*; Kroger,A.; Viegas,N.; Erck,C.; Hecht,Hans-Jürgen*; Lünsdorf,Heinrich*; Roubin,R.; Moharregh-Khiabani,D.; Wagner,K.; Ocklenburg,F.; Jeron,Andreas*; Garritsen,H.; Arstila,T.P.; Kekalainen,E.; Balling,Rudi*; Hauser,Hansjörg*; Buer,J.; Weiss,Siegfried*; (2009). GARP: a key receptor controlling FOXP3 in human regulatory T cells. Journal of Cellular and Molecular Medicine: 13 9, 3343-3357 PubMed
  • Legrand,N.; Ploss,A.; Balling,Rudi*; Becker,P.D.; Borsotti,C.; Brezillon,N.; Debarry,J.; de,Jong Y.; Deng,H.; Di Santo,J.P.; Eisenbarth,S.; Eynon,E.; Flavell,R.A.; Guzmán,Carlos A.*; Huntington,N.D.; Kremsdorf,D.; Manns,M.P.; Manz,M.G.; Mention,J.J.; Ott,M.; Rathinam,C.; Rice,C.M.; Rongvaux,A.; Stevens,S.; Spits,H.; Strick-Marchand,H.; Takizawa,H.; van Lent,A.U.; Wang,C.; Weijer,K.; Willinger,T.; Ziegler,P.; (2009). Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host and Microbe: 6 1, 5-9 PubMed
  • He,F.; Balling,Rudi*; Zeng,An-Ping*; (2009). Reverse engineering and verification of gene networks: principles, assumptions, and limitations of present methods and future perspectives. Journal of Biotechnology: 144 3, 190-203 PubMed
  • Bilitewski,Ursula*; (2008). Determination of immunomodulatory effects: focus on functional analysis of phagocytes as representatives of the innate immune system. Analytical and Bioanalytical Chemistry: 391 5, 1545-1554 DOI: 10.1007/s00216-008-2089-6 Volltext HZI-Repositorium PubMed
  • Wesolowski,J.; Hassan,R.Y.; Hodde,S.; Bardroff,C.; Bilitewski,Ursula*; (2008). Sensing of oxygen in microtiter plates: a novel tool for screening drugs against pathogenic yeasts. Analytical and Bioanalytical Chemistry: 391 5, 1731-1737 PubMed
  • Bilitewski,Ursula*; (2007). Biochemische Methoden in der Wasseranalytik - Stand der Technik und Perspektiven. Teil III: Signalprofile und effektbasierte Analytik. Vom Wasser - Das Journal: 105 4, 3-30
  • Behnsen,J.; Narang,P.; Hasenberg,M.; Gunzer,F.; Bilitewski,Ursula*; Klippel,N.; Rohde,Manfred*; Brock,M.; Brakhage,A.A.; Gunzer,Matthias*; (2007). Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans. PLoS Pathogens: 3 2, 0138-0151 DOI: 10.1371/journal.ppat.0030013 HZI-Repositorium PubMed
  • Klippel,N.; Bilitewski,Ursula*; (2007). Phagocytosis assay based on living Candida albicans for the detection of effects of chemicals on macrophage function. Analytical Letters: 40 7, 1400-1411 DOI: 10.1080/00032710701327047 HZI-Repositorium
  • Bilitewski,Ursula*; (2006). Biochemische Methoden in der Wasseranalytik - Stand der Technik und Perspektiven - Teil II: Organismische Tests. Vom Wasser - Das Journal: 104 3, 7-19 HZI-Repositorium
  • Bilitewski,Ursula*; (2006). Biochemische Methoden in der Wasseranalytik - Stand der Technik und Perspektiven - Teil. I: Molekulare Tests. Vom Wasser - Das Journal: 104 1, 3-34 HZI-Repositorium
  • Bilitewski,Ursula*; (2006). Protein sensing assay formats and devices. Annals in Chimica Acta: 568, 232-247

Publikationen bis 2005

Hier finden Sie ein pdf-Dokument mit allen Publikationen bis 2005.