Systemmedizin der Infektionskrankheiten

Systemmedizin zielt auf das ganzheitliche Verständnis von Gesundheit und Krankheiten mit Blick auf personalisierte Medizin ab. Indem klinische Daten mit phenomenologischen Modellen und dem Potential von Computersimulationen verbunden werden, wollen wir mit unserer Foschung die zugrundeliegenden Mechanismen zwischen Immunsystem und Krankheit verstehen, maßgeschneiderte und effektive Immuneingriffe und -behandlungen für besonders anfällige Personengruppen (z.B. ältere und immungeschwächte Menschen) bieten und neue mathematische und rechnerbetonte Methoden entwickeln, um die Hürden der Translation von Systemmedizin hin zu Medizin und Klinik zu überwinden.

Publikationen

2014

S. Jaafoura,M. G. de Goër de Herve, E. A. Hernandez-Vargas, H. Hendel-Chavez, M. Abdoh, M. C. Mateo, R. Krzysiek,M. Merad, R. Seng, M. Tardieu, J. F. Delfraissy, C. Goujard and Y. Taoufik, Progressive contraction of the latent HIV reservoir around a core of less-differentiated ​CD4+ memory T Cells, Nature Communications, Vol.5, 5407, 1-8, 2014. [PDF]
 
E.A. Hernandez-Vargas, E. Wilk, L. Canini, F. Toapanta, S. Binder, A. Uvarovskii, T. Ross, C.A. Guzman, A.S. Perelson, M.
Meyer-Hermann, Effects of aging on influenza virus infection dynamics, Journal of Virology, Vol.88 (8), 4123–4131, 2014. [PDF]
 
M. Haering, A. Hördt, M. Meyer-Hermann and E. A. Hernandez-Vargas, Computational study to determine when to initiate and alternate therapy in HIV infection, BioMed Research International, Vol. 2014, 2014 [PDF]
 
E.A. Hernandez-Vargas, P. Colaneri, R.H. Middleton, Switching Strategies to Mitigate HIV Mutation, IEEE Transactions on Control Systems Technology, Vol. 22 (4), 1623 - 1628, 2014. [PDF]
 
Alma Y. Alanis, Miguel Hernandez-Gonzalez, Esteban A. Hernandez-Vargas, Observers for biological systems, Applied Soft Computing, Vol.24, 1175–1182, 2014. [PDF]
 
2013
 
E.A. Hernandez-Vargas, P. Colaneri, R. Middleton. Optimal therapy scheduling for a simplified HIV infection model, Automatica, Vol.49 (9), 2874–2880, 2013. [PDF]
 
E.A. Hernandez-Vargas, R. Middleton, Modeling the three stages in HIV infection, Journal of Theoretical Biology, Vol. 320, 33-40, 2013. [PDF]
 
C. Schmeitz, E.A. Hernandez-Vargas, R. Flyer, A.H. Guse, M. Meyer-Hermann, A mathematical model of T lymphocyte calcium dynamics derived from single transmembrane protein properties, Frontiers in immunology, Vol. 4, 2013. [PDF]
 
2012
 
M. Hernandez-Gonzalez, A. Alanis, E.A. Hernandez-Vargas, Decentralized Discrete-Time Neural Control for a Quanser 2-DOF Helicopter, Applied Soft Computing, Vol. 12, 2462–2469, 2012. [PDF]
 
E.A. Hernandez-Vargas, P. Colaneri, R. Middleton, Sub-optimal switching with dwell time constraints for control of viral mutation, IEEE Conference on Decision Control, Maui, Hawaii, 2012. [PDF]
 
E.A. Hernandez-Vargas, M. Meyer-Hermann, Innate immune system dynamics to influenza virus, IFAC Symposium on Biological and Medical Systems, Budapest, 2012. [PDF]
 
E. A. Hernandez, A.Y. Alanis, E. N. Sanchez, Discrete-time neural observer for HIV infection dynamics, Word Automation Congress, Puerto Vallarta, Mexico 2012. [PDF]
 
2011
 
J. Ferreira, E.A. Hernandez-Vargas, R. Middleton, Computer Simulation of Structured Treatment Interruption for HIV infection, Computers Methods and Programs in Biomedicine, Vol. 104 (2), 50-61 2011. [PDF]
 
E.A. Hernandez-Vargas, Dhagash Mehta, R. Middleton, Towards modeling HIV long term behavior, IFAC World Congress, Milan, Italy, 2011. [PDF]
 
E.A. Hernandez-Vargas, R. Middleton, P. Colaneri, Optimal and MPC switching strategies for mitigating viral mutation escape, IFAC World Congress, Milan, Italy, 2011. [PDF]
 

S. Zhan, E.A. Hernandez-Vargas, R. Middleton, A mathematical study on immune activation and related dynamics in HIV infection, IEEE Conference on Decision Control, Orlando, 2011. [PDF]
 
2010
 
E.A. Hernandez-Vargas, P. Colaneri, R. Middleton, F. Blanchini, Discrete-time control for switched positive systems with application to mitigating viral escape, International Journal of Robust and Nonlinear Control, Vol. 21 (10), 1093–1111, 2010. [PDF]
 
 
A. Alanis, E. N. Sanchez, A. Loukianov, E.A. Hernandez-Vargas, Discrete-time recurrent high order neural networks for nonlinear identification, Journal of the Franklin Institute, Vol. 347 (7), 1253-1265, 2010 [PDF]
 
E.A. Hernandez-Vargas, P. Colaneri, R. Middleton, F. Blanchini, Dynamic optimization algorithms to mitigate HIV escape, IEEE Conference on Decision Control, Atlanta, 2010 [PDF]
 
R. Middleton, P. Colaneri, E.A. Hernandez-Vargas, F. Blanchini, Continuous-time optimal control for switched positive systems with application to mitigating viral escape, IFAC Symposium on Nonlinear Control Systems, Bologna, Italy, 2010 [PDF]
 
2009
 
E.A. Hernandez-Vargas, E. N. Sanchez, C. Cadet, J. F. Beteau, Neural observer based hybrid intelligent scheme for activated sludge wastewater treatment, Chemical and Biochemical Engineering Quarterly Journal, Vol. 23 (4), 2009. [PDF]
 
E.A. Hernandez-Vargas, A. Alanis, E. N. Sanchez, M. Hernandez-Gonzalez, Supervisor difuso funcional aplicado a una planta urbana de tratamiento de aguas residuales basado en un observador neuronal, Ingeniería Química, Vol. 36, 2009. [PDF]
 
2008
 
E. A. Hernandez, E. N. Sanchez, C. Cadet, J. F. Beteau, Observer based hybrid intelligent control for activated sludge wastewater treatment, Latin American Congress of Automatic Control, Merida, Venezuela, 2008. [PDF]
 
E. N. Sanchez, E.A. Hernandez, C. Cadet, J. F. Beteau, Hybrid intelligent control for activated sludge wastewater treatment, IEEE Multi-Conference on Systems and Control, San Antonio, Texas, 2008. [PDF]
 
E. N. Sanchez, E.A. Hernandez, C. Cadet, J. F. Beteau, Discrete-time recurrent high order neural observer for activated sludge wastewater treatment, IEEE World Congress on Computational Intelligence, Hong Kong, 2008. [PDF]
 
2007
 
J.G. Segovia-Hernandez, E.A. Hernandez–Vargas, J.A. Marquez–Muñoz, Control Properties of Thermally Coupled Distillation Sequences for Different Operating Conditions, Computers and Chemical Engineering Journal, Vol. 31, 867-874, 2007. [PDF]
 
2006
 
E. A. Hernandez–Vargas, J.G. Segovia- Hernandez, S. Hernandez, A. Jimenez, Dynamic analysis of distillation with thermal coupling for different operating conditions, Distillation and Absorption 2006, IChemeE Symp. No. 152, Edited by Eva Sorensen, UK, 728-736. ISBN:0-85295-505-7 [PDF]
 
2005
 
J.G. Segovia-Hernandez, E.A. Hernandez–Vargas, J.A. Marquez–Muñoz, S. Hernandez, A. Jimenez, Control properties and thermodynamic analysis of two alternatives to thermally coupled distillation systems with side columns, Chemical and Biochemical Engineering Quarterly Journal, Vol.19 (4), 325-332, 2005. [PDF]

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