Experimentelle Immunologie

Tagtäglich werden wir mit verschiedenen Krankheitserregern konfrontiert, die unser Immunsystem mit unterschiedlichen Strategien abwehren muss. Die Zellen des Immunsystems haben dafür gelernt zu unterscheiden, was harmlose körpereigene Strukturen sind und was potenziell gefährlich körperfremde. Manchmal entstehen aber auch Immunzellen, die falsch programmiert sind und körpereigene Strukturen angreifen. Erfahren Sie hier, wie sich unser Körper dagegen schützt und wie wir diesen Schutzmechanismus therapeutisch nutzen können.

Publications of Workgroup

  • Milanez-Almeida,P.; Ulas,T.; Pasztoi,M.; Glage,S.; Schughart,K.; Lutz,M.B.; Schultze,J.L.; Hühn,J.; (2015). CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice. 5 4, 246-255 PubMed
  • Hühn,J.; Floess,S.; Ohkura,N.; Sakaguchi,S.; (2015). Comment on "cutting edge: Epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory t cells in tumors from mice and humans". Journal of Immunology: 194 8, 3533-353400221767 WEBURLS
  • Yang,B.H.; Flöß,Stefan; Hagemann,S.; Deyneko,Igor V.; Gröbe,Lothar; Pezoldt,J.; Sparwasser,Tim; Lochner,M.; Hühn,Jochen; (2015). Development of a unique epigenetic signature during in vivo Th17 differentiation. 43 3, 1537-1548 DOI: 10.1093/nar/gkv014 HZI-Repositorium PubMed
  • Hühn,J.; Beyer,M.; (2015). Epigenetic and transcriptional control of Foxp3 regulatory T cells. 27 1, 10-18 PubMed
  • Roesner,L.M.; Flöß,S.; Witte,T.; Olek,S.; Hühn,J.; Werfel,T.; (2015). Foxp3 regulatory T cells are expanded in severe atopic dermatitis patients. Allergy: European Journal of Allergy and Clinical Immunology: 70 12, 1656-1660 PubMed
  • Yang,B.H.; Hagemann,S.; Mamareli,P.; Lauer,U.; Hoffmann,U.; Beckstette,M.; Fohse,L.; Prinz,I.; Pezoldt,J.; Suerbaum,S.; Sparwasser,T.; Hamann,A.; Floess,S.; Hühn,J.; Lochner,M.; (2015). Foxp3 T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. 9, 444-457 PubMed
  • Klysz,D.; Tai,X.; Robert,P.A.; Craveiro,M.; Cretenet,G.; Oburoglu,L.; Mongellaz,C.; Flöß,S.; Fritz,V.; Matias,M.I.; Yong,C.; Surh,N.; Marie,J.C.; Hühn,J.; Zimmermann,V.; Kinet,S.; Dardalhon,V.; Taylor,N.; (2015). Glutamine-dependent alpha-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation. 8 396, ra97 PubMed
  • Braun,A.; Dewert,N.; Brunnert,F.; Schnabel,V.; Hardenberg,J.H.; Richter,B.; Zachmann,K.; Cording,S.; Classen,A.; Brans,R.; Hamann,A.; Hühn,J.; Schon,M.P.; (2015). Integrin alpha(CD103) Is Involved in Regulatory T-Cell Function in Allergic Contact Hypersensitivity. PubMed
  • Pasztoi,M.; Pezoldt,J.; Hühn,J.; (2015). Microenvironment Matters: Unique Conditions Within Gut-Draining Lymph Nodes Favor Efficient De Novo Induction of Regulatory T Cells. 136, 35-56 PubMed
  • Walter,F.R.; Veszelka,S.; Pasztoi,M.; Peterfi,Z.A.; Toth,A.; Rakhely,G.; Cervenak,L.; Abraham,C.S.; Deli,M.A.; (2015). Tesmilifene modifies brain endothelial functions and opens the blood-brain/blood-glioma barrier. 134 6, 1040-1054 PubMed
  • Tebartz,C.; Horst,Sarah A.; Sparwasser,Tim; Hühn,Jochen; Beineke,A.; Peters,G.; Medina,Eva; (2014). A Major Role for Myeloid-Derived Suppressor Cells and a Minor Role for Regulatory T Cells in Immunosuppression during Staphylococcus aureus Infection. Journal of Immunology: 194 3, 1100-1111 PubMed
  • Khailaie,Sahamoddin; Robert,Phillipe A.; Toker,Aras; Hühn,Jochen; Meyer-Hermann,Michael; (2014). A signal integration model of thymic selection and natural regulatory T cell commitment. Journal of Immunology: 193 12, 5983-5996 PubMed
  • Mayer,Christian T.; Lahl,K.; Milanez-Almeida,P.; Watts,D.; Dittmer,U.; Fyhrquist,N.; Hühn,Jochen; Kopf,M.; Kretschmer,K.; Rouse,B.; Sparwasser,Tim; (2014). Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice. Immunity, Inflammation and Disease: 2 3, 162-165 DOI: 10.1002/iid3.33 HZI-Repositorium PubMed
  • Berod,L.; Friedrich,C.; Nandan,A.; Freitag,J.; Hagemann,S.; Harmrolfs,K.; Sandouk,A.; Hesse,C.; Castro,C.N.; Bahre,H.; Tschirner,S.K.; Gorinski,N.; Gohmert,M.; Mayer,C.T.; Hühn,Jochen; Ponimaskin,E.; Abraham,Wolf-Rainer; Müller,Rolf; Lochner,M.; Sparwasser,Tim; (2014). De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nature medicine: 20, 1327-1333 PubMed
  • Milanez-Almeida,P.; Klawonn,F.; Meyer-Hermann,M.; Hühn,J.; (2014). Differential control of immune cell homeostasis by Foxp3(+) regulatory T cells in murine peripheral lymph nodes and spleen. 4 3, 147-155 PubMed
  • Prajeeth,C.K.; Lohr,K.; Flöß,Stefan; Zimmermann,J.; Ulrich,R.; Gudi,V.; Beineke,A.; Baumgartner,W.; Muller,M.; Hühn,Jochen; Stangel,M.; (2014). Effector molecules released by Th1 but not Th17 cells drive an M1 response in microglia. Brain, Behavior, and Immunity: 37, 248-259 DOI: 10.1016/j.bbi.2014.01.001 HZI-Repositorium PubMed
  • Milanez-Almeida,P.; Meyer-Hermann,Michael; Toker,Aras; Khailaie,Sahamoddin; Hühn,Jochen; (2014). Foxp3 regulatory T-cell homeostasis quantitatively differs in murine peripheral lymph nodes and spleen. European Journal of Immunology: 45, 153-166 PubMed
  • Prajeeth,C.K.; Beineke,A.; Iskandar,C.; Gudi,V.; Herder,V.; Gerhauser,I.; Haist,V.; Teich,R.; Hühn,J.; Baumgartner,W.; Stangel,M.; (2014). Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice. 11 1, 180 PubMed
  • Franckaert,D.; Dooley,J.; Roos,E.; Flöß,Stefan; Hühn,Jochen; Luche,H.; Fehling,H.J.; Liston,A.; Linterman,M.A.; Schlenner,S.M.; (2014). Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3 and Foxp3 T cells. Immunology and Cell Biology: 93 4, 417-423 DOI: 10.1038/icb.2014.108 HZI-Repositorium PubMed
  • Cording,S.; Wahl,B.; Kulkarni,D.; Chopra,H.; Pezoldt,Jörn; Buettner,M.; Dummer,A.; Hadis,U.; Heimesaat,M.; Bereswill,S.; Falk,C.; Bode,U.; Hamann,A.; Fleissner,D.; Hühn,Jochen; Pabst,O.; (2014). The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes. Mucosal Immunology: 7 2, 359-368 DOI: 10.1038/mi.2013.54 PubMed
  • Schreiber,L.; Pietzsch,Beate; Flöß,Stefan; Farah,Carla; Jänsch,Lothar; Schmitz,Ingo; Hühn,Jochen; (2014). The Treg-specific demethylated region stabilizes Foxp3 expression independently of NF-?B signaling. PLoS ONE: 9 2, e8831819326203 WEBURLS
  • Delacher,M.; Schreiber,L.; Richards,D.M.; Farah,C.; Feuerer,M.; Hühn,J.; (2014). Transcriptional control of regulatory T cells. 381, 83-124 PubMed
  • Khailaie,Sahamoddin; Bahrami,F.; Janahmadi,M.; Milanez-Almeida,P.; Hühn,Jochen; Meyer-Hermann,Michael; (2013). A mathematical model of immune activation with a unified self-nonself concept. Frontiers in Immunology: 4, 474 DOI: 10.3389/fimmu.2013.00474 HZI-Repositorium PubMed
  • Toker,Aras; Engelbert,D.; Garg,Garima; Polansky,Julia K.; Floess,Stefan; Miyao,T.; Baron,U.; Düber,Sandra; Geffers,Robert; Giehr,P.; Schallenberg,S.; Kretschmer,K.; Olek,S.; Walter,J.; Weiss,Siegfried; Hori,S.; Hamann,A.; Hühn,Jochen; (2013). Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus. Journal of Immunology: 190 7, 3180-318800221767 WEBURLS
  • Cording,S.; Fleißner,Diana; Heimesaat,M.M.; Bereswill,S.; Loddenkemper,C.; Uematsu,S.; Akira,S.; Hamann,A.; Hühn,Jochen; (2013). Commensal microbiota drive proliferation of conventional and Foxp3 regulatory CD4 T cells in mesenteric lymph nodes and Peyer's patches. European Journal of Microbiology and Immunology: 3 1, 1-10 PubMed
  • Kühlhorn,F.; Rath,M.; Schmoeckel,K.; Cziupka,K.; Nguyen,H.H.; Hildebrandt,P.; Hünig,T.; Sparwasser,Tim; Hühn,Jochen; Pötschke,C.; Bröker,B.M.; (2013). Foxp3+ Regulatory T Cells Are Required for Recovery from Severe Sepsis. PLoS ONE: 8 5, e6510919326203 WEBURLS
  • Huang,Yi-Ju; Haist,V.; Baumgartner,W.; Fohse,L.; Prinz,I.; Suerbaum,S.; Floess,Stefan; Hühn,Jochen; (2013). Induced and thymus-derived Foxp3 regulatory T cells share a common niche. European Journal of Immunology: 44 2, 460-468 DOI: 10.1002/eji.201343463 PubMed
  • Kreutzfeldt,M.; Bergthaler,A.; Fernandez,M.; Brück,W.; Steinbach,K.; Vorm,M.; Coras,R.; Blümcke,I.; Bonilla,W.V.; Fleige,A.; Forman,R.; Müller,W.; Becher,B.; Misgeld,T.; Kerschensteiner,M.; Pinschewer,D.D.; Merkler,D.; (2013). Neuroprotective intervention by interferon-? blockade prevents CD8+ T cell-mediated dendrite and synapse loss. Journal of Experimental Medicine: 210 10, 2087-210300221007 DOI: 10.1084/jem.20122143 HZI-Repositorium PubMed
  • Sledzinska,A.; Hemmers,S.; Mair,F.; Gorka,O.; Ruland,J.; Fairbairn,L.; Nissler,A.; Müller,W.; Waisman,A.; Becher,B.; Buch,T.; (2013). TGF-beta Signalling Is Required for CD4+ T Cell Homeostasis But Dispensable for Regulatory T Cell Function. PLoS Biology: 11 10, e100167415449173 DOI: 10.1371/journal.pbio.1001674 HZI-Repositorium PubMed
  • Schweer,Janina; Kulkarni,Devesha; Kochut,Annika; Pezoldt,Jörn; Pisano,Fabio; Pils,Marina C.; Genth,H.; Hühn,Jochen; Dersch,Petra; (2013). The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases. PLoS Pathogens: 9 11, e1003746 DOI: 10.1371/journal.ppat.1003746 HZI-Repositorium PubMed
  • Patzelt,Diana; Wang,Hui; Buchholz,I.; Rohde,Manfred; Gröbe,Lothar; Pradella,S.; Neumann,A.; Schulz,S.; Heyber,S.; Munch,K.; Munch,R.; Jahn,D.; Wagner-Döbler,Irene; Tomasch,Jürgen; (2013). You are what you talk: quorum sensing induces individual morphologies and cell division modes in Dinoroseobacter shibae. ISME Journal: 7 12, 2274-2286 DOI: 10.1038/ismej.2013.107 PubMed
  • Hinz,D.; Bauer,M.; Roder,S.; Olek,S.; Hühn,Jochen; Sack,U.; Borte,M.; Simon,J.C.; Lehmann,I.; Herberth,G.; (2012). Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year. Allerg: European Journal of Allergy and Clinical Immunology: 67 3, 380-389 PubMed
  • König,S.; Probst-Kepper,M.; Reinl,T.; Jeron,A.; Hühn,Jochen; Schraven,B.; Jänsch,Lothar; (2012). First insight into the kinome of human regulatory T cells. PLoS ONE: 7 7, e40896 DOI: 10.1371/journal.pone.0040896 HZI-Repositorium PubMed
  • Gereke,Marcus; Autengruber,A.; Gröe,Lothar; Jeron,A.; Bruder,Dunja; Stegemann-Koniszewski,S.; (2012). Flow cytometric isolation of primary murine type II alveolar epithelial cells for functional and molecular studies. Journal of Visualized Experiments: JoVE: 701940087X DOI: 4322. WEBURLS
  • O'Connor,R.A.; Floess,S.; Hühn,Jochen; Jones,S.A.; Anderton,S.M.; (2012). Foxp3(+) Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production. European Journal of Immunology: 42 5, 1174-1179 PubMed
  • Koenecke,C.; Lee,C.W.; Thamm,K.; Fohse,L.; Schafferus,M.; Mittrucker,H.W.; Floess,S.; Hühn,Jochen; Ganser,A.; Forster,R.; Prinz,I.; (2012). IFN-gamma Production by Allogeneic Foxp3+ Regulatory T Cells Is Essential for Preventing Experimental Graft-versus-Host Disease. Journal of Immunology: 189 6, 2890-2896 PubMed
  • Schuster,M.; Glauben,R.; Plaza-Sirvent,C.; Schreiber,L.; Annemann,M.; Floess,S.; Kuhl,A.A.; Clayton,L.K.; Sparwasser,Tim; Schulze-Osthoff,K.; Pfeffer,K.; Hühn,Jochen; Siegmund,B.; Schmitz,Ingo; (2012). IkappaB(NS) Protein Mediates Regulatory T Cell Development via Induction of the Foxp3 Transcription Factor. Immunity: 37 6, 998-1008 DOI: 10.1016/j.immuni.2012.08.023 HZI-Repositorium PubMed
  • Herder,V.; Gerhauser,I.; Klein,S.K.; Almeida,P.; Kummerfeld,M.; Ulrich,R.; Seehusen,F.; Rohn,K.; Schaudien,D.; Baumgartner,W.; Hühn,Jochen; Beineke,A.; (2012). Interleukin-10 expression during the acute phase is a putative prerequisite for delayed viral elimination in a murine model for multiple sclerosis. Journal of Neuroimmunology: 249 1-2, 27-39 PubMed
  • Bettini,M.L.; Pan,F.; Bettini,M.; Finkelstein,D.; Rehg,J.E.; Floess,S.; Bell,B.D.; Ziegler,S.F.; Hühn,Jochen; Pardoll,D.M.; Vignali,D.A.; (2012). Loss of epigenetic modification driven by the foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity: 36 5, 717-730 PubMed
  • Weiss,J.M.; Bilate,A.M.; Gobert,M.; Ding,Y.; de Lafaille,M.A.C.; Parkhurst,C.N.; Xiong,H.; Dolpady,J.; Frey,A.B.; Ruocco,M.G.; Yang,Y.; Flöss,Stefan; Hühn,Jochen; Oh,S.; Li,M.O.; Niec,R.E.; Rudensky,A.Y.; Dustin,M.L.; Littman,D.R.; Lafaille,J.J.; (2012). Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosagenerated induced Foxp3+ T reg cells. Journal of Experimental Medicine: 209 10, 1723-174200221007 DOI: 10.1084/jem.20120914 HZI-Repositorium PubMed
  • Miyao,T.; Floess,S.; Setoguchi,R.; Luche,H.; Fehling,H.J.; Waldmann,H.; Hühn,Jochen; Hori,S.; (2012). Plasticity of foxp3(+) T cells reflects promiscuous foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity: 36 2, 262-275 PubMed
  • Ohkura,N.; Hamaguchi,M.; Morikawa,H.; Sugimura,K.; Tanaka,A.; Ito,Y.; Osaki,M.; Tanaka,Y.; Yamashita,R.; Nakano,N.; Hühn,Jochen; Fehling,H.J.; Sparwasser,Tim*; Nakai,K.; Sakaguchi,S.; (2012). T cell receptor stimulation-induced epigenetic changes and foxp3 expression are independent and complementary events required for treg cell development. Immunity: 37 5, 785-799 DOI: 10.1016/j.immuni.2012.09.010 HZI-Repositorium PubMed
  • Berod,L.; Puttur,F.; Hühn,Jochen; Sparwasser,Tim*; (2012). Tregs in infection and vaccinology: heroes or traitors?. Microbial Biotechnology: 5 2, 260-269 PubMed
  • Kahlisch,L.; Henne,K.; Gröbe,Lothar*; Brettar,I.; Höfle,Manfred G.*; (2011). Assessing the Viability of Bacterial Species in Drinking Water by Combined Cellular and Molecular Analyses3526. Microbial Ecology: 63 2, 383-397 DOI: 10.1007/s00248-011-9918-4 PubMed
  • Mayer,C.T.; Floess,S.; Baru,A.M.; Lahl,K.; Hühn,Jochen*; Sparwasser,T.; (2011). CD8(+) Foxp3(+) T cells share developmental and phenotypic features with classical CD4(+) Foxp3(+) regulatory T cells but lack potent suppressive activity. European Journal of Immunology: 41 3, 716-725 DOI: 10.1002/eji.201040913 HZI-Repositorium PubMed
  • Steinfelder,S.; Floess,S.; Engelbert,D.; Haeringer,B.; Baron,U.; Rivino,L.; Steckel,B.; Gruetzkau,A.; Olek,S.; Geginat,J.; Hühn,Jochen*; Hamann,A.; (2011). Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells. Blood: 117 10, 2839-2846 DOI: 10.1182/blood-2010-06-293027 HZI-Repositorium PubMed
  • Brand,S.; Teich,René*; Dicke,T.; Harb,H.; Yildirim,A.O.; Tost,J.; Schneider-Stock,R.; Waterland,R.A.; Bauer,U.M.; von,Mutius E.; Garn,H.; Pfefferle,P.I.; Renz,H.; (2011). Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes. Journal of Allergy and Clinical Immunology: 128 3, 618-625.e7 PubMed
  • Blankenhaus,B.; Klemm,U.; Eschbach,M.L.; Sparwasser,T.; Hühn,Jochen*; Kuhl,A.A.; Loddenkemper,C.; Jacobs,T.; Breloer,M.; (2011). Strongyloides ratti infection induces expansion of Foxp3(+) regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice. Journal of Immunology: 186 7, 4295-4305 PubMed
  • Toker,A.; Hühn,Jochen*; (2011). To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms. Science Signaling: 4 158, e4 DOI: 10.1126/scisignal.2001783 HZI-Repositorium PubMed
  • Hubert,S.; Rissiek,B.; Klages,K.; Hühn,Jochen*; Sparwasser,T.; Haag,F.; Koch-Nolte,F.; Boyer,O.; Seman,M.; Adriouch,S.; (2010). Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. Journal of Experimental Medicine: 207 12, 2561-2568 DOI: 10.1084/jem.20091154 HZI-Repositorium PubMed
  • Humrich,J.Y.; Morbach,H.; Undeutsch,R.; Enghard,P.; Rosenberger,S.; Weigert,O.; Kloke,L.; Heimann,J.; Gaber,T.; Brandenburg,S.; Scheffold,A.; Hühn,Jochen*; Radbruch,A.; Burmester,G.R.; Riemekasten,G.; (2010). Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus. Proceedings of the National Academy of Sciences of the United States of America: 107 1, 204-209 PubMed
  • Polansky,J.K.; Schreiber,L.; Thelemann,C.; Ludwig,L.; Kruger,M.; Baumgrass,R.; Cording,S.; Floess,S.; Hamann,A.; Hühn,Jochen*; (2010). Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells. Journal of Molecular Medicine: 88 10, 1029-1040 PubMed
  • Menning,A.; Loddenkemper,C.; Westendorf,A.M.; Szilagyi,B.; Buer,J.; Siewert,C.; Hamann,A.; Hühn,Jochen*; (2010). Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation. European Journal of Immunology: 40 9, 2539-2548 PubMed
  • Klages,K.; Mayer,C.T.; Lahl,K.; Loddenkemper,C.; Teng,M.W.; Ngiow,S.F.; Smyth,M.J.; Hamann,A.; Hühn,Jochen*; Sparwasser,T.; (2010). Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Research: 70 20, 7788-7799 PubMed
  • Koenecke,C.; Czeloth,N.; Bubke,A.; Schmitz,S.; Kissenpfennig,A.; Malissen,B.; Hühn,Jochen*; Ganser,A.; Forster,R.; Prinz,I.; (2009). Alloantigen-specific de novo-induced Foxp3(+) Treg revert in vivo and do not protect from experimental GVHD. European Journal of Immunology: 39 11, 3091-3096 PubMed
  • Hühn,Jochen*; Polansky,J.K.; Hamann,A.; (2009). Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?. Nature Reviews Immunology: 9 2, 83-89 DOI: 10.1038/nri2474 PubMed
  • Rausch,S.; Hühn,Jochen*; Loddenkemper,C.; Hepworth,M.R.; Klotz,C.; Sparwasser,T.; Hamann,A.; Lucius,R.; Hartmann,S.; (2009). Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3(+) cells. Europen Journal of Immunology: 39 11, 3066-3077 PubMed
  • Hoffmann,P.; Boeld,T.J.; Eder,R.; Hühn,Jochen*; Floess,S.; Wieczorek,G.; Olek,S.; Dietmaier,W.; Andreesen,R.; Edinger,M.; (2009). Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. European Journal of Immunology: 39 4, 1088-1097 PubMed
  • Schaub,B.; Liu,J.; Hoppler,S.; Schleich,I.; Hühn,Jochen*; Olek,S.; Wieczorek,G.; Illi,S.; von,Mutius E.; (2009). Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. Journal of Allergy and Clinical Immunology: 123 4, 774-782 DOI: 10.1016/j.jaci.2009.01.056 HZI-Repositorium PubMed
  • Lahl,K.; Mayer,C.T.; Bopp,T.; Hühn,Jochen*; Loddenkemper,C.; Eberl,G.; Wirnsberger,G.; Dornmair,K.; Geffers,Robert*; Schmitt,E.; Buer,J.; Sparwasser,T.; (2009). Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice. Journal of Immunology: 183 9, 5662-5672 PubMed
  • Wieczorek,G.; Asemissen,A.; Model,F.; Turbachova,I.; Floess,S.; Liebenberg,V.; Baron,U.; Stauch,D.; Kotsch,K.; Pratschke,J.; Hamann,A.; Loddenkemper,C.; Stein,H.; Volk,H.D.; Hoffmuller,U.; Grutzkau,A.; Mustea,A.; Hühn,Jochen*; Scheibenbogen,C.; Olek,S.; (2009). Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue. Cancer Research: 69 2, 599-608 PubMed
  • Loddenkemper,C.; Hoffmann,C.; Stanke,J.; Nagorsen,D.; Baron,U.; Olek,S.; Hühn,Jochen*; Ritz,J.P.; Stein,H.; Kaufmann,A.M.; Schneider,A.; Cichon,G.; (2009). Regulatory (FOXP3+) T cells as target for immune therapy of cervical intraepithelial neoplasia and cervical cancer. Cancer Science: 100 6, 1112-1117 PubMed
  • Doebis,C.; Siegmund,K.; Loddenkemper,C.; Lowe,J.B.; Issekutz,A.C.; Hamann,A.; Hühn,Jochen*; Syrbe,U.; (2008). Cellular players and role of selectin ligands in leukocyte recruitment in a T-cell-initiated delayed-type hypersensitivity reaction. American Journal of Pathology: 173 4, 1067-1076 PubMed
  • Apostolou,I.; Verginis,P.; Kretschmer,K.; Polansky,J.; Hühn,Jochen*; von,Boehmer H.; (2008). Peripherally induced Treg: mode, stability, and role in specific tolerance. Journal of Clinical Immunology: 28 6, 619-624 PubMed
  • Menning,A.; Hopken,U.E.; Siegmund,K.; Lipp,M.; Hamann,A.; Hühn,Jochen*; (2007). Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets. European Journal of Immunology: 37 6, 1575-1583 PubMed
  • Baron,U.; Floess,S.; Wieczorek,G.; Baumann,K.; Grutzkau,A.; Dong,J.; Thiel,A.; Boeld,T.J.; Hoffmann,P.; Edinger,M.; Turbachova,I.; Hamann,A.; Olek,S.; Hühn,Jochen*; (2007). DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. European Journal of Immunology: 37 9, 2378-2389 DOI: 10.3390/md8122976 HZI-Repositorium PubMed
  • Marson,A.; Kretschmer,Karsten*; Frampton,G.M.; Jacobsen,E.S.; Polansky,J.K.; MacIsaac,K.D.; Levine,S.S.; Fraenkel,E.; von,Boehmer H.; Young,R.A.; (2007). Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature: 445 7130, 931-935 PubMed
  • Siewert,C.; Menning,A.; Dudda,J.; Siegmund,K.; Lauer,U.; Floess,S.; Campbell,D.J.; Hamann,A.; Hühn,Jochen*; (2007). Induction of organ-selective CD4+ regulatory T cell homing. European Journal of Immunology: 37 4, 978-989 PubMed
  • Lahl,K.; Loddenkemper,C.; Drouin,C.; Freyer,J.; Arnason,J.; Eberl,G.; Hamann,A.; Wagner,H.; Hühn,Jochen*; Sparwasser,T.; (2007). Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. Journal of Experimental Medicine: 204 1, 57-63 PubMed
  • Kroger,A.; Stirnweiss,A.; Pulverer,J.E.; Klages,K.; Grashoff,M.; Reimann,J.; Hauser,Hansjörg*; (2007). Tumor suppression by IFN regulatory factor-1 is mediated by transcriptional down-regulation of cyclin D1. Cancer Research: 67 7, 2972-2981 PubMed
  • Polansky,J.K.; Hühn,Jochen*; (2007). [To be or not to be a Treg: epigenetic regulation of Foxp3 expression in regulatory T cells]. Zeitschrift für Rheumatologie: 66 5, 417-420 PubMed

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  • Prof. Jochen Hühn

    Jochen Hühn

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    0531 6181-3310

    0531 6181-3399

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