Epidemiologie erforscht Gesundheit und Krankheit auf der Bevölkerungsebene – die Infektionsepidemiologie beschäftigt sich mit übertragbaren Krankheiten. Ihre Werkzeuge und Methoden sind systematische Befragungen, klinische Untersuchungen und labordiagnostische Nachweise sowie statistische Analysen. So können Ursachen und Risikofaktoren für Infektionen identifiziert werden. Die Infektionsepidemiologie trägt zur Entwicklung von Präventionsmaßnahmen, ebenso wie zur Früherkennung und Therapie von Erkrankungen bei. Zudem überprüft sie die Wirksamkeit solcher Maßnahmen.



Prof. Dr. Gérard Krause

Abteilungsleiter Epidemiologie



Cuny C, Arnold P, Hermes J, Eckmanns T, Mehraj J, Schoenfelder S, Ziebuhr W, Zhao Q, Wang Y, Fessler AT, Krause G, Schwarz S, Witte W (2016) Occurrence of cfr-mediated multiresistance in staphylococci from veal calves and pigs, from humans at the corresponding farms, and from veterinarians and their family members. Vet Microbiol

Karo B, Krause G, Hollo V, van der Werf MJ, Castell S, Hamouda O, Haas W (2016) Impact of HIV infection on treatment outcome of tuberculosis in Europe. AIDS 30: 1089-1098

Klett-Tammen CJ, Krause G, Seefeld L, Ott JJ (2016) Determinants of tetanus, pneumococcal and influenza vaccination in the elderly: a representative cross-sectional study on knowledge, attitude and practice (KAP). BMC Public Health 16: 121



Akmatov MK, Kimani-Murage E, Pessler F, Guzman CA, Krause G, Kreienbrock L, Mikolajczyk RT (2015) Evaluation of invalid vaccine doses in 31 countries of the WHO African Region. Vaccine 33: 892-901

Akmatov MK, Rübsamen N, Schultze A, Kemmling Y, Obi N, Günther K, Ahrens W, Pessler F, Krause G, Mikolajczyk RT (2015) Diverse recruitment strategies result in different participation percentages in a web-based study, but in similar compliance. Int J Public Health 60: 937-943

Fähnrich C, Denecke K, Adeoye OO, Benzler J, Claus H, Kirchner G, Mall S, Richter R, Schapranow MP, Schwarz N, Tom-Aba D, Uflacker M, Poggensee G, Krause G (2015) Surveillance and Outbreak Response Management System (SORMAS) to support the control of the Ebola virus disease outbreak in West Africa. Euro Surveill 20

Harder T, Abu Sin M, Bosch-Capblanch X, Bruno C, de Carvalho Gomes H, Duclos P, Eckmanns T, Elder R, Ellis S, Forland F, Garner P, James R, Jansen A, Krause G, Levy-Bruhl D, Morgan A, Meerpohl JJ, Norris S, Rehfuess E, Sanchez-Vivar A, Schunemann H, Takla A, Wichmann O, Zingg W, Zuiderent-Jerak T (2015) Towards a framework for evaluating and grading evidence in public health. Health Policy 119: 732-736

Mohr O, Schink SB, Eckmanns T, Krause G (2015) Tuberculosis in public ground transport - is there enough evidence to justify contact tracing? Expert Rev Anti Infect Ther 13: 1-3

Rübsamen N, Castell S, Horn J, Karch A, Ott JJ, Raupach-Rosin H, Zoch B, Krause G, Mikolajczyk RT (2015) Ebola risk perception in Germany, 2014. Emerg Infect Dis 21: 1012-1018

Santos-Hövener C, Marcus U, Koschollek C, Oudini H, Wiebe M, Ouedraogo OI, Mayamba P, M’bayo R, Sanogo A, Bakambamba A, Gangarova T, Hamouda O, Dierks M-L, Krause G (2015) Konzeption einer Studie zu sexueller Gesundheit bei in Deutschland lebenden Afrikanern. Prävention und Gesundheitsförderung 10: 68-75

Santos-Hövener C, Marcus U, Koschollek C, Oudini H, Wiebe M, Ouedraogo OI, Thorlie A, Bremer V, Hamouda O, Dierks ML, An der Heiden M, Krause G (2015) Determinants of HIV, viral hepatitis and STI prevention needs among African migrants in Germany; a cross-sectional survey on knowledge, attitudes, behaviors and practices. BMC Public Health 15: 753

Schweitzer A, Akmatov MK, Kindler F, Kemmling Y, Kreienbrock L, Krause G, Pessler F (2015) The impact of distance and duration of travel on participation rates and participants' satisfaction: results from a pilot study at one study centre in Pretest 2 of the German National Cohort. BMJ open 5: e007461

Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ (2015) Estimations of worldwide prevalence of chronic hepatitis B virus infection: a systematic review of data published between 1965 and 2013. Lancet 386: 1546-1555

Schweitzer A, Krause G, Pessler F, Akmatov MK (2015) Improved coverage and timing of childhood vaccinations in two post-Soviet countries, Armenia and Kyrgyzstan. BMC Public Health 15: 798



Akmatov MK, Mehraj J, Gatzemeier A, Strömpl J, Witte W, Krause G, Pessler F (2014) Serial home-based self-collection of anterior nasal swabs to detect Staphylococcus aureus carriage in a randomized population-based study in Germany. Int J Infect Dis 25: 4-10

Böhmer MM, Walter D, Ehrhardt J, Reiter S, Krause G, Wichmann O (2014) [Seasonal and pandemic influenza vaccination: coverage and attitude among private physicians in Germany]. Gesundheitswesen 76: 44-47

Castell S, Akmatov MK, Obi N, Flesh-Janys D, Nieters A, Kemmling Y, Pessler F, Krause G (2014) Test-retest reliability of an infectious disease questionnaire and evaluation of self-assessed vulnerability to infections : findings of Pretest 2 of the German National Cohort. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57: 1300-1307

Castell S, Krause G, Schmitt M, Pawlita M, Delere Y, Obi N, Flesch-Janys D, Kemmling Y, Kaufmann AM (2014) Feasibility and acceptance of cervicovaginal self-sampling within the German National Cohort (Pretest 2). Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57: 1270-1276

Hamouda O, Krause G, Pigeot I (2014) [National Cohort -- the largest health study in Germany]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57: 1243-1245

Harder T, Takla A, Rehfuess E, Sanchez-Vivar A, Matysiak-Klose D, Eckmanns T, Krause G, de Carvalho Gomes H, Jansen A, Ellis S, Forland F, James R, Meerpohl JJ, Morgan A, Schünemann H, Zuiderent-Jerak T, Wichmann O (2014) Evidence-based decision-making in infectious diseases epidemiology, prevention and control: matching research questions to study designs and quality appraisal tools. BMC Med Res Methodol 14: 69

Mall S, Akmatov MK, Schultze A, Ahrens W, Obi N, Pessler F, Krause G (2014) Web-based questionnaires to capture acute infections in long-term cohorts: findings of a feasibility study. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57: 1308-1314

Mehraj J, Akmatov MK, Strompl J, Gatzemeier A, Layer F, Werner G, Pieper DH, Medina E, Witte W, Pessler F, Krause G (2014) Methicillin-sensitive and methicillin-resistant Staphylococcus aureus nasal carriage in a random sample of non-hospitalized adult population in northern Germany. PLoS One 9: e107937

Plass D, Mangen MJ, Kraemer A, Pinheiro P, Gilsdorf A, Krause G, Gibbons CL, A VANL, Mc DS, Brooke RJ, Kramarz P, Cassini A, Kretzschmar ME (2014) The disease burden of hepatitis B, influenza, measles and salmonellosis in Germany: first results of the burden of communicable diseases in Europe study. Epidemiol Infect 142: 2024-2035

Schultze A, Akmatov MK, Andrzejak M, Karras N, Kemmling Y, Maulhardt A, Wieghold S, Ahrens W, Günther K, Schlenz H, Krause G, Pessler F (2014) Comparison of stool collection on site versus at home in a population-based study : feasibility and participants' preference in Pretest 2 of the German National Cohort. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57: 1264-1269

Schultze A, Akmatov MK, Castell S, Karch A, Ahrens W, Günther K, Schlenz H, Flesch-Janys D, Obi N, Pessler F, Krause G (2014) Collection of vaccination data in the German National Cohort : Findings of a feasibility study in three study centers. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57: 1292-1299

Sievers C, Akmatov MK, Kreienbrock L, Hille K, Ahrens W, Günther K, Flesch-Janys D, Obi N, Michels KB, Fricke J, Greiser KH, Kaaks R, Peter HH, Pessler F, Nieters A, Krause G (2014) Evaluation of a questionnaire to assess selected infectious diseases and their risk factors : findings of a multicenter study. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57: 1283-1291



Balabanova Y, Klar S, Delere Y, Wilking H, Faber MS, Lassen SG, Gilsdorf A, Dupke S, Nitschke M, Sayk F, Grunow R, Krause G (2013) Serological evidence of asymptomatic infections during Escherichia coli O104:H4 outbreak in Germany in 2011. PLoS One 8: e73052

Buchholz U, Müller MA, Nitsche A, Sanewski A, Wevering N, Bauer-Balci T, Bonin F, Drosten C, Schweiger B, Wolff T, Muth D, Meyer B, Buda S, Krause G, Schaade L, Haas W (2013) Contact investigation of a case of human novel coronavirus infection treated in a German hospital, October-November 2012. Euro Surveill 18

Cediel-Becerra NM, Krause G (2013) Herramientas para la toma de decisiones en salud pública basadas en la evidencia y priorización de enfermedades. Rev salud pública 15: 694-706

Heideking M, Lander F, Hufnagel M, Pfeifer Y, Wicker E, Krause G, Berner R (2013) Antibiotic susceptibility profiles of neonatal invasive isolates of Escherichia coli from a 2-year nationwide surveillance study in Germany, 2009-2010. Eur J Clin Microbiol Infect Dis 32: 1221-1223

Krause G (2013) Electronic surveillance for infectious diseases in Germany. In Infectious Disease Surveillance, M’ikanatha NM, Lynfield R, Van Beneden CA, de Valk H (eds), 2nd edn, pp 426-433. Wiley-Blackwell

Krause G, Frank C, Gilsdorf A, Mielke M, Schaade L, Stark K, Burger R (2013) [The 2011 HUS epidemic in Germany. Challenges for disease control: what should be improved?]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56: 56-66

Mohr O, Hermes J, Schink SB, Askar M, Menucci D, Swaan C, Goetsch U, Monk P, Eckmanns T, Poggensee G, Krause G (2013) Development of a risk assessment tool for contact tracing people after contact with infectious patients while travelling by bus or other public ground transport: a Delphi consensus approach. BMJ open 3: e002939

Ultsch B, Köster I, Reinhold T, Siedler A, Krause G, Icks A, Schubert I, Wichmann O (2013) Epidemiology and cost of herpes zoster and postherpetic neuralgia in Germany. Eur J Health Econ 14: 1015-1026

Ultsch B, Weidemann F, Reinhold T, Siedler A, Krause G, Wichmann O (2013) Health economic evaluation of vaccination strategies for the prevention of herpes zoster and postherpetic neuralgia in Germany. BMC Health Serv Res 13: 359



Askar MA, Mohr O, Eckmanns T, Krause G, Poggensee G (2012) Quantitative assessment of passenger flows in Europe and its implications for tracing contacts of infectious passengers. Euro Surveill 17

Böhmer MM, Walter D, Falkenhorst G, Muters S, Krause G, Wichmann O (2012) Barriers to pandemic influenza vaccination and uptake of seasonal influenza vaccine in the post-pandemic season in Germany. BMC Public Health 12: 938

Dehnert M, Fingerle V, Klier C, Talaska T, Schlaud M, Krause G, Wilking H, Poggensee G (2012) Seropositivity of Lyme borreliosis and associated risk factors: a population-based study in Children and Adolescents in Germany (KiGGS). PLoS One 7: e41321

Klein S, Schoneberg I, Krause G (2012) [The historical development of immunization in Germany. From compulsory smallpox vaccination to a National Action Plan on Immunization]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 55: 1512-1523

Laude G, Kist M, Krause G (2012) [Networks of National Reference Centers and associated Consiliary Laboratories in Germany]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 55: 223-230

Mohr O, Askar M, Schink S, Eckmanns T, Krause G, Poggensee G (2012) Evidence for airborne infectious disease transmission in public ground transport--a literature review. Euro Surveill 17

Schweickert B, Noll I, Feig M, Claus H, Krause G, Velasco E, Eckmanns T (2012) MRSA-surveillance in Germany: data from the Antibiotic Resistance Surveillance System (ARS) and the mandatory surveillance of MRSA in blood. Eur J Clin Microbiol Infect Dis 31: 1855-1865

STEC Workshop Reporting Group (Stark K, Bauerfeind R, Bernard H, Eckmanns T, Ethelberg S, Flieger A, Giesecke J, Greiner M, Karch H, Krause G, Mielke M, O'Brien SJ, Pulz M, Scheutz F, Schielke A, Stahl RA, Takkinen J, Tarr PI, Tauxe RV, Werber D.) (2012) Experiences from the Shiga toxin-producing Escherichia coli O104:H4 outbreak in Germany and research needs in the field, Berlin, 28-29 November 2011. Euro Surveill 17

Suess T, Remschmidt C, Schink SB, Schweiger B, Heider A, Milde J, Nitsche A, Schroeder K, Doellinger J, Braun C, Haas W, Krause G, Buchholz U (2012) Comparison of shedding characteristics of seasonal influenza virus (sub)types and influenza A(H1N1)pdm09; Germany, 2007-2011. PLoS One 7: e51653

Suess T, Remschmidt C, Schink SB, Schweiger B, Nitsche A, Schroeder K, Doellinger J, Milde J, Haas W, Koehler I, Krause G, Buchholz U (2012) The role of facemasks and hand hygiene in the prevention of influenza transmission in households: results from a cluster randomised trial; Berlin, Germany, 2009-2011. BMC Infect Dis 12: 26

Velasco E, Noll I, Espelage W, Ziegelmann A, Krause G, Eckmanns T (2012) A survey of outpatient antibiotic prescribing for cystitis. Deutsches Arzteblatt international 109: 878-884

Velasco E, Ziegelmann A, Eckmanns T, Krause G (2012) Eliciting views on antibiotic prescribing and resistance among hospital and outpatient care physicians in Berlin, Germany: results of a qualitative study. BMJ open 2: e000398

Walter D, Böhmer M, Reiter S, Krause G, Wichmann O (2012) Risk perception and information-seeking behaviour during the 2009/10 influenza A(H1N1)pdm09 pandemic in Germany. Euro Surveill 17

Werber D, Krause G, Frank C, Fruth A, Flieger A, Mielke M, Schaade L, Stark K (2012) Outbreaks of virulent diarrheagenic Escherichia coli--are we in control? BMC Med 10: 11

Wicker S, Gottschalk R, Wolff U, Krause G, Rabenau HF (2012) [Influenza vaccination rates in Hessian hospitals]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 55: 932-936

Wilking H, Gotsch U, Meier H, Thiele D, Askar M, Dehnert M, Frank C, Fruth A, Krause G, Prager R, Stark K, Boddinghaus B, Bellinger O, Gottschalk R (2012) Identifying risk factors for shiga toxin-producing Escherichia coli by payment information. Emerg Infect Dis 18: 169-170



Alpers A, Weist K, Eckmanns T, Krause G (2011) Untersuchung von Infektionsausbrüchen im Krankenhaus. In Hygiene in Krankenhaus und Praxis, Eikmann T, Christiansen B, Exner M (eds), pp 73-85. Ecomed

Altmann M, Spode A, Altmann D, Wadl M, Benzler J, Eckmanns T, Krause G, An der Heiden M (2011) Timeliness of surveillance during outbreak of Shiga Toxin-producing Escherichia coli infection, Germany, 2011. Emerg Infect Dis 17: 1906-1909

Askar M, Faber MS, Frank C, Bernard H, Gilsdorf A, Fruth A, Prager R, Hohle M, Suess T, Wadl M, Krause G, Stark K, Werber D (2011) Update on the ongoing outbreak of haemolytic uraemic syndrome due to Shiga toxin-producing Escherichia coli (STEC) serotype O104, Germany, May 2011. Euro Surveill 16

Balabanova Y, Gilsdorf A, Buda S, Burger R, Eckmanns T, Gartner B, Gross U, Haas W, Hamouda O, Hubner J, Janisch T, Kist M, Kramer MH, Ledig T, Mielke M, Pulz M, Stark K, Suttorp N, Ulbrich U, Wichmann O, Krause G (2011) Communicable diseases prioritized for surveillance and epidemiological research: results of a standardized prioritization procedure in Germany, 2011. PLoS One 6: e25691

Böhmer MM, Walter D, Krause G, Muters S, Gosswald A, Wichmann O (2011) Determinants of tetanus and seasonal influenza vaccine uptake in adults living in Germany. Hum Vaccin 7: 1317-1325

Böhmer MM, Walter D, Muters S, Krause G, Wichmann O (2011) Seasonal influenza vaccine uptake in Germany 2007/2008 and 2008/2009: results from a national health update survey. Vaccine 29: 4492-4498

Buchholz U, Bernard H, Werber D, Böhmer MM, Remschmidt C, Wilking H, Delere Y, an der Heiden M, Adlhoch C, Dreesman J, Ehlers J, Ethelberg S, Faber M, Frank C, Fricke G, Greiner M, Hohle M, Ivarsson S, Jark U, Kirchner M, Koch J, Krause G, Luber P, Rosner B, Stark K, Kuhne M (2011) German outbreak of Escherichia coli O104:H4 associated with sprouts. N Engl J Med 365: 1763-1770

Dudareva S, Schweiger B, Thamm M, Hohle M, Stark K, Krause G, Buda S, Haas W (2011) Prevalence of antibodies to 2009 pandemic influenza A (H1N1) virus in German adult population in pre- and post-pandemic period. PLoS One 6: e21340

Frank C, Faber MS, Askar M, Bernard H, Fruth A, Gilsdorf A, Hohle M, Karch H, Krause G, Prager R, Spode A, Stark K, Werber D, team HUSi (2011) Large and ongoing outbreak of haemolytic uraemic syndrome, Germany, May 2011. Euro Surveill 16

Frank C, Werber D, Cramer JP, Askar M, Faber M, an der Heiden M, Bernard H, Fruth A, Prager R, Spode A, Wadl M, Zoufaly A, Jordan S, Kemper MJ, Follin P, Muller L, King LA, Rosner B, Buchholz U, Stark K, Krause G, Team HUSI (2011) Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany. N Engl J Med 365: 1771-1780

Gilsdorf A, Krause G (2011) Authors reply: Prioritisation of infectious diseases in public health: feedback on the prioritisation methodology, 15 July 2008 to 15 January 2009. Euro Surveill 16

Gilsdorf A, Krause G (2011) Prioritisation of infectious diseases in public health: feedback on the prioritisation methodology, 15 July 2008 to 15 January 2009. Euro Surveill 16

Siedler A, Mankertz A, Feil F, Ahlemeyer G, Hornig A, Kirchner M, Beyrer K, Dreesman J, Scharkus S, Marcic A, Reiter S, Matysiak-Klose D, Santibanez S, Krause G, Wichmann O (2011) Closer to the goal: efforts in measles elimination in Germany 2010. J Infect Dis 204 Suppl 1: S373-380

Suess T, Remschmidt C, Schink S, Luchtenberg M, Haas W, Krause G, Buchholz U (2011) Facemasks and intensified hand hygiene in a German household trial during the 2009/2010 influenza A(H1N1) pandemic: adherence and tolerability in children and adults. Epidemiol Infect 139: 1895-1901

Ultsch B, Siedler A, Rieck T, Reinhold T, Krause G, Wichmann O (2011) Herpes zoster in Germany: quantifying the burden of disease. BMC Infect Dis 11: 173

Ultsch B, Siedler A, Rieck T, Reinhold T, Krause G, Wichmann O (2011) PIH15 Estimating Herpes Zoster Disease Burden in Germany. Value in Health 14: A400

Van Kerkhove MD, Vandemaele KA, Shinde V, Jaramillo-Gutierrez G, Koukounari A, Donnelly CA, Carlino LO, Owen R, Paterson B, Pelletier L, Vachon J, Gonzalez C, Hongjie Y, Zijian F, Chuang SK, Au A, Buda S, Krause G, Haas W, Bonmarin I, Taniguichi K, Nakajima K, Shobayashi T, Takayama Y, Sunagawa T, Heraud JM, Orelle A, Palacios E, van der Sande MA, Wielders CC, Hunt D, Cutter J, Lee VJ, Thomas J, Santa-Olalla P, Sierra-Moros MJ, Hanshaoworakul W, Ungchusak K, Pebody R, Jain S, Mounts AW, WHO Working Group for Risk Factors for Severe H1N1pdm Infection (2011) Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis. PLoS Med 8: e1001053

Velasco E, Espelage W, Faber M, Noll I, Ziegelmann A, Krause G, Eckmanns T (2011) A national cross-sectional study on socio-behavioural factors that influence physicians' decisions to begin antimicrobial therapy. Infection 39: 289-297

Wadl M, Rieck T, Nachtnebel M, Greutelaers B, an der Heiden M, Altmann D, Hellenbrand W, Faber M, Frank C, Schweickert B, Krause G, Benzler J, Eckmanns T, surveillance HUS, laboratory t (2011) Enhanced surveillance during a large outbreak of bloody diarrhoea and haemolytic uraemic syndrome caused by Shiga toxin/verotoxin-producing Escherichia coli in Germany, May to June 2011. Euro Surveill 16

Walter D, Böhmer MM, Heiden M, Reiter S, Krause G, Wichmann O (2011) Monitoring pandemic influenza A(H1N1) vaccination coverage in Germany 2009/10 - results from thirteen consecutive cross-sectional surveys. Vaccine 29: 4008-4012



  • SORMAS - die Zukunft der Seuchenüberwachung

    Epidemiologen und IT-Experten aus Deutschland und Nigeria haben gemeinsam eine innovative App entwickelt, die helfen soll Epidemien wie Ebola oder Cholera zu bekämpfen - das Surveillance Outbreak Response Management and Analysis System (SORMAS). Unser Video zeigt, warum eine Anwendung wie SORMAS dringend benötigt wird und wie das einzigartige Konzept SORMAS so vielversprechend macht:

Audio Podcast

  • Staphylococcus aureus – ein Leben in der Nase2000 zufällig ausgewählte Braunschweiger Bürger haben in diesem Juni Post vom HZI erhalten – mit der Bitte, an einer Studie über die Verbreitung von Staphylococcus aureus teilzunehmen. Varianten des Bakteriums sind unter dem Kürzel MRSA als Krankenhauskeime zu trauriger Berühmtheit gelangt. Unsere Wissenschaftler wollen nun erforschen, wie viele Gesunde – außerhalb von Krankenhäusern – mit diesem Keim Leben. Und sie suchen nach Risikofaktoren, die Staphylococcus aureus die Besiedlung des Menschen erleichtern. Begleiten Sie Frank Pessler und Jaishri Mehraj ein Stück in die Welt der Epidemiologie...
  • Proben und Fragebögen für die Infektionsforschung - Die Nationale Kohorte Diabetes mellitus, Krebs, Arterienverkalkung und diverse Infektionen sind Volkskrankheiten, über die wir viel zu wenig wissen. Mit der Nationalen Kohorte wollen Wissenschaftler diesen Krankheiten auf den Grund gehen und neue Strategien gegen sie entwickeln. Frank Pessler und Manas Akmatov nehmen die Infektionen ins Visier. Lassen Sie sich erklären, wie ihnen 225.000 Menschen dabei helfen sollen…
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