Bioinformatik der Infektionsforschung

Die Abteilung “Bioinformatik der Infektionsforschung” erforscht mit computergestützten Techniken das menschliche Mikrobiom, virale und bakterielle Pathogene sowie menschliche Zelllinien anhand von großen biologischen und epidemiologischen Datensätzen. Durch die Analyse von Metaom-, Populationsgenom- und Einzelzellgenomdaten erzeugen wir experimentell überprüfbare Hypothesen,  wie z.b. welche Veränderungen an Proteinen oder welche Gene assoziiert sind mit dem Auftreten einer Krankheit, von Antibiotikaresistenzen oder dem Ausweichen des Immunschutzes durch Pathogene. Wir arbeiten mit experimentellen Kollaborationspartnern zusammen, um unsere Erkenntnisse zu verifizieren und deren Translation in die medizinische Diagnostik und Behandlung zu fördern. Um die Forschungsziele zu erreichen, entwickelt die Abteilung auch neue Algorithmen und Bioinformatik-Software.

Leitung

Ausgewählte Publikationen

  • Sczyrba, A.*, Hofmann, P.*, Belmann, P.*, Koslicki, D., Janssen, S., Droge, J., Gregor, I., Majda, S., Fiedler, J., Dahms, E., Bremges, A., Fritz, A., Garrido-Oter, R., Jorgensen, T. S., Shapiro, N., Blood, P. D., Gurevich, A., Bai, Y., Turaev, D., DeMaere, M. Z., Chikhi, R., Nagarajan, N., Quince, C., Meyer, F., Balvociute, M., Hansen, L. H., Sorensen, S. J., Chia, B. K. H., Denis, B., Froula, J. L., Wang, Z., Egan, R., Don Kang, D., Cook, J. J., Deltel, C., Beckstette, M., Lemaitre, C., Peterlongo, P., Rizk, G., Lavenier, D., Wu, Y. W., Singer, S. W., Jain, C., Strous, M., Klingenberg, H., Meinicke, P., Barton, M. D., Lingner, T., Lin, H. H., Liao, Y. C., Silva, G. G. Z., Cuevas, D. A., Edwards, R. A., Saha, S., Piro, V. C., Renard, B. Y., Pop, M., Klenk, H. P., Goker, M., Kyrpides, N. C., Woyke, T., Vorholt, J. A., Schulze-Lefert, P., Rubin, E. M., Darling, A. E., Rattei, T. & McHardy, A. C. (*shared first authors) Critical Assessment of Metagenome Interpretation-a benchmark of metagenomics software. Nature Methods (2017) 14, 1063, doi:10.1038/nmeth.4458.
  • Asgari, E., Münch, P. C., Lesker, T. R., McHardy, A. C.* & Mofrad, M. R. K.* (*shared last authors) DiTaxa: nucleotide-pair encoding of 16S rRNA for host phenotype and biomarker detection. Bioinformatics (2019) 35, 2498, doi:10.1093/bioinformatics/bty954.
  • Meyer, F., Bremges, A., Belmann, P., Janssen, S., McHardy, A. C.* & Koslicki, D.* (*shared last authors) Assessing taxonomic metagenome profilers with OPAL. Genome Biol (2019) 20, 51, doi:10.1186/s13059-019-1646-y.
  • Fritz, A.*, Hofmann, P.*, Majda, S., Dahms, E., Dröge, J., Fiedler, J., Lesker, T. R., Belmann, P., DeMaere, M. Z., Darling, A. E., Sczyrba, A., Bremges, A. & McHardy, A. C. (*shared first authors) CAMISIM: simulating metagenomes and microbial communities. Microbiome (2019) 7, 17, doi:10.1186/s40168-019-0633-6

Publikationen

2021

2020

2019

  • Amann, R. I., Baichoo, S., Blencowe, B. J., Bork, P., Borodovsky, M., Brooksbank, C., Chain, P. S. G., Colwell, R. R., Daffonchio, D. G., Danchin, A., de Lorenzo, V., Dorrestein, P. C., Finn, R. D., Fraser, C. M., Gilbert, J. A., Hallam, S. J., Hugenholtz, P., Ioannidis, J. P. A., Jansson, J. K., Kim, J. F., Klenk, H. P., Klotz, M. G., Knight, R., Konstantinidis, K. T., Kyrpides, N. C., Mason, C. E., McHardy, A. C., Meyer, F., Ouzounis, C. A., Patrinos, A. A. N., Podar, M., Pollard, K. S., Ravel, J., Muñoz, A. R., Roberts, R. J., Rosselló-Móra, R., Sansone, S. A., Schloss, P. D., Schriml, L. M., Setubal, J. C., Sorek, R., Stevens, R. L., Tiedje, J. M., Turjanski, A., Tyson, G. W., Ussery, D. W., Weinstock, G. M., White, O., Whitman, W. B. & Xenarios, I. Consent insufficient for data release-Response. Science (2019) 364, 446, doi:10.1126/science.aax7509.
  • Amann, R. I., Baichoo, S., Blencowe, B. J., Bork, P., Borodovsky, M., Brooksbank, C., Chain, P. S. G., Colwell, R. R., Daffonchio, D. G., Danchin, A., de Lorenzo, V., Dorrestein, P. C., Finn, R. D., Fraser, C. M., Gilbert, J. A., Hallam, S. J., Hugenholtz, P., Ioannidis, J. P. A., Jansson, J. K., Kim, J. F., Klenk, H. P., Klotz, M. G., Knight, R., Konstantinidis, K. T., Kyrpides, N. C., Mason, C. E., McHardy, A. C., Meyer, F., Ouzounis, C. A., Patrinos, A. A. N., Podar, M., Pollard, K. S., Ravel, J., Muñoz, A. R., Roberts, R. J., Rosselló-Móra, R., Sansone, S. A., Schloss, P. D., Schriml, L. M., Setubal, J. C., Sorek, R., Stevens, R. L., Tiedje, J. M., Turjanski, A., Tyson, G. W., Ussery, D. W., Weinstock, G. M., White, O., Whitman, W. B. & Xenarios, I. Toward unrestricted use of public genomic data. Science (2019) 363, 350, doi:10.1126/science.aaw1280.
  • Asgari, E., Garakani, K., McHardy, A. C. & Mofrad, M. R. K. MicroPheno: predicting environments and host phenotypes from 16S rRNA gene sequencing using a k-mer based representation of shallow sub-samples. Bioinformatics (2019) 35, 1082, doi:10.1093/bioinformatics/bty652.
  • Asgari, E., McHardy, A. C. & Mofrad, M. R. K. Probabilistic variable-length segmentation of protein sequences for discriminative motif discovery (DiMotif) and sequence embedding (ProtVecX)Sci Rep (2019) 9, 3577, doi:10.1038/s41598-019-38746-w.
  • Asgari, E., Münch, P. C., Lesker, T. R., McHardy, A. C. & Mofrad, M. R. K. DiTaxa: nucleotide-pair encoding of 16S rRNA for host phenotype and biomarker detection. Bioinformatics (2019) 35, 2498, doi:10.1093/bioinformatics/bty954.
  • Bledea, R., Vasudevaraja, V., Patel, S., Stafford, J., Serrano, J., Esposito, G., Tredwin, L. M., Goodman, N., Kloetgen, A., Golfinos, J. G., Zagzag, D., Weigelt, B., Iafrate, A. J., Sulman, E. P., Chi, A. S., Dogan, S., Reis-Filho, J. S., Chiang, S., Placantonakis, D., Tsirigos, A. & Snuderl, M. Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers. Sci Rep (2019) 9, 16830, doi:10.1038/s41598-019-53262-7.
  • Chen, X., Glytsou, C., Zhou, H., Narang, S., Reyna, D. E., Lopez, A., Sakellaropoulos, T., Gong, Y., Kloetgen, A., Yap, Y. S., Wang, E., Gavathiotis, E., Tsirigos, A., Tibes, R. & Aifantis, I. Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment. Cancer Discov (2019) 9, 890, doi:10.1158/2159-8290.Cd-19-0117.
  • Di Giammartino, D. C.*, Kloetgen, A.*, Polyzos, A., Liu, Y., Kim, D., Murphy, D., Abuhashem, A., Cavaliere, P., Aronson, B., Shah, V., Dephoure, N., Stadtfeld, M., Tsirigos, A. & Apostolou, E. (*shared first authors) KLF4 is involved in the organization and regulation of pluripotency-associated three-dimensional enhancer networks. Nat Cell Biol (2019) 21, 1179, doi:10.1038/s41556-019-0390-6.
  • Fritz, A., Hofmann, P., Majda, S., Dahms, E., Dröge, J., Fiedler, J., Lesker, T. R., Belmann, P., DeMaere, M. Z., Darling, A. E., Sczyrba, A., Bremges, A. & McHardy, A. C. CAMISIM: simulating metagenomes and microbial communities. Microbiome (2019) 7, 17, doi:10.1186/s40168-019-0633-6.
  • Halaby, M. J., Hezaveh, K., Lamorte, S., Ciudad, M. T., Kloetgen, A., MacLeod, B. L., Guo, M., Chakravarthy, A., Medina, T. D. S., Ugel, S., Tsirigos, A., Bronte, V., Munn, D. H., Pugh, T. J., De Carvalho, D. D., Butler, M. O., Ohashi, P. S., Brooks, D. G. & McGaha, T. L. GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment. Sci Immunol (2019) 4, eaax8189, doi:10.1126/sciimmunol.aax8189.
  • Hoell, J. I., Ginzel, S., Kuhlen, M., Kloetgen, A., Gombert, M., Fischer, U., Hein, D., Demir, S., Stanulla, M., Schrappe, M., Zur Stadt, U., Bader, P., Babor, F., Schuster, F., Strahm, B., Alten, J., Moericke, A., Escherich, G., von Stackelberg, A., Thiele, R., McHardy, A. C., Peters, C., Bornhauser, B., Bourquin, J. P., Krause, S., Enczmann, J., Meyer, L. H., Eckert, C., Borkhardt, A. & Meisel, R. Pediatric ALL relapses after allo-SCT show high individuality, clonal dynamics, selective pressure, and druggable targets. Blood Adv (2019) 3, 3143, doi:10.1182/bloodadvances.2019000051.
  • Ingenhag, D., Reister, S., Auer, F., Bhatia, S., Wildenhain, S., Picard, D., Remke, M., Hoell, J. I., Kloetgen, A., Sohn, D., Jänicke, R. U., Koegler, G., Borkhardt, A. & Hauer, J. The homeobox transcription factor HB9 induces senescence and blocks differentiation in hematopoietic stem and progenitor cells. Haematologica (2019) 104, 35, doi:10.3324/haematol.2018.189407.
  • Klingen, T. R., Loers, J., Stanelle-Bertram, S., Gabriel, G. & McHardy, A. C. Structures and functions linked to genome-wide adaptation of human influenza A viruses. Sci Rep (2019) 9, 6267, doi:10.1038/s41598-019-42614-y.
  • Kloetgen, A., Münch, P. C., Borkhardt, A., Hoell, J. I. & McHardy, A. C. Corrigendum to: Biochemical and bioinformatic methods for elucidating the role of RNA-protein interactions in posttranscriptional regulation. Brief Funct Genomics (2019) 18, 433, doi:10.1093/bfgp/elz014.
  • Kloetgen, A.*, Thandapani, P.*, Tsirigos, A.* & Aifantis, I.* (*shared first authors) 3D Chromosomal Landscapes in Hematopoiesis and Immunity. Trends Immunol (2019) 40, 809, doi:10.1016/j.it.2019.07.003.
  • Lhoumaud, P., Badri, S., Rodriguez-Hernaez, J., Sakellaropoulos, T., Sethia, G., Kloetgen, A., Cornwell, M., Bhattacharyya, S., Ay, F., Bonneau, R., Tsirigos, A. & Skok, J. A. NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains. Nat Commun (2019) 10, 4843, doi:10.1038/s41467-019-12811-4.
  • Meyer, F., Bremges, A., Belmann, P., Janssen, S., McHardy, A. C.* & Koslicki, D.* (*shared last authors) Assessing taxonomic metagenome profilers with OPAL. Genome Biol (2019) 20, 51, doi:10.1186/s13059-019-1646-y.
  • Vatanen, T., Plichta, D. R., Somani, J., Münch, P. C., Arthur, T. D., Hall, A. B., Rudolf, S., Oakeley, E. J., Ke, X., Young, R. A., Haiser, H. J., Kolde, R., Yassour, M., Luopajärvi, K., Siljander, H., Virtanen, S. M., Ilonen, J., Uibo, R., Tillmann, V., Mokurov, S., Dorshakova, N., Porter, J. A., McHardy, A. C., Lähdesmäki, H., Vlamakis, H., Huttenhower, C., Knip, M. & Xavier, R. J. Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life. Nat Microbiol (2019) 4, 470, doi:10.1038/s41564-018-0321-5.
  • Vatanen, T., Plichta, D. R., Somani, J., Münch, P. C., Arthur, T. D., Hall, A. B., Rudolf, S., Oakeley, E. J., Ke, X., Young, R. A., Haiser, H. J., Kolde, R., Yassour, M., Luopajärvi, K., Siljander, H., Virtanen, S. M., Ilonen, J., Uibo, R., Tillmann, V., Mokurov, S., Dorshakova, N., Porter, J. A., McHardy, A. C., Lähdesmäki, H., Vlamakis, H., Huttenhower, C., Knip, M. & Xavier, R. J. Publisher Correction: Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life. Nat Microbiol (2019) 4, 545, doi:10.1038/s41564-019-0393-x.
  • Wang, E., Lu, S. X., Pastore, A., Chen, X., Imig, J., Chun-Wei Lee, S., Hockemeyer, K., Ghebrechristos, Y. E., Yoshimi, A., Inoue, D., Ki, M., Cho, H., Bitner, L., Kloetgen, A., Lin, K. T., Uehara, T., Owa, T., Tibes, R., Krainer, A. R., Abdel-Wahab, O. & Aifantis, I. Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia. Cancer Cell (2019) 35, 369, doi:10.1016/j.ccell.2019.01.010.
  • Zhou, N., Jiang, Y., Bergquist, T. R., Lee, A. J., Kacsoh, B. Z., Crocker, A. W., Lewis, K. A., Georghiou, G., Nguyen, H. N., Hamid, M. N., Davis, L., Dogan, T., Atalay, V., Rifaioglu, A. S., Dalkıran, A., Cetin Atalay, R., Zhang, C., Hurto, R. L., Freddolino, P. L., Zhang, Y., Bhat, P., Supek, F., Fernández, J. M., Gemovic, B., Perovic, V. R., Davidović, R. S., Sumonja, N., Veljkovic, N., Asgari, E., Mofrad, M. R. K., Profiti, G., Savojardo, C., Martelli, P. L., Casadio, R., Boecker, F., Schoof, H., Kahanda, I., Thurlby, N., McHardy, A. C., Renaux, A., Saidi, R., Gough, J., Freitas, A. A., Antczak, M., Fabris, F., Wass, M. N., Hou, J., Cheng, J., Wang, Z., Romero, A. E., Paccanaro, A., Yang, H., Goldberg, T., Zhao, C., Holm, L., Törönen, P., Medlar, A. J., Zosa, E., Borukhov, I., Novikov, I., Wilkins, A., Lichtarge, O., Chi, P. H., Tseng, W. C., Linial, M., Rose, P. W., Dessimoz, C., Vidulin, V., Dzeroski, S., Sillitoe, I., Das, S., Lees, J. G., Jones, D. T., Wan, C., Cozzetto, D., Fa, R., Torres, M., Warwick Vesztrocy, A., Rodriguez, J. M., Tress, M. L., Frasca, M., Notaro, M., Grossi, G., Petrini, A., Re, M., Valentini, G., Mesiti, M., Roche, D. B., Reeb, J., Ritchie, D. W., Aridhi, S., Alborzi, S. Z., Devignes, M. D., Koo, D. C. E., Bonneau, R., Gligorijević, V., Barot, M., Fang, H., Toppo, S., Lavezzo, E., Falda, M., Berselli, M., Tosatto, S. C. E., Carraro, M., Piovesan, D., Ur Rehman, H., Mao, Q., Zhang, S., Vucetic, S., Black, G. S., Jo, D., Suh, E., Dayton, J. B., Larsen, D. J., Omdahl, A. R., McGuffin, L. J., Brackenridge, D. A., Babbitt, P. C., Yunes, J. M., Fontana, P., Zhang, F., Zhu, S., You, R., Zhang, Z., Dai, S., Yao, S., Tian, W., Cao, R., Chandler, C., Amezola, M., Johnson, D., Chang, J. M., Liao, W. H., Liu, Y. W., Pascarelli, S., Frank, Y., Hoehndorf, R., Kulmanov, M., Boudellioua, I., Politano, G., Di Carlo, S., Benso, A., Hakala, K., Ginter, F., Mehryary, F., Kaewphan, S., Björne, J., Moen, H., Tolvanen, M. E. E., Salakoski, T., Kihara, D., Jain, A., Šmuc, T., Altenhoff, A., Ben-Hur, A., Rost, B., Brenner, S. E., Orengo, C. A., Jeffery, C. J., Bosco, G., Hogan, D. A., Martin, M. J., O'Donovan, C., Mooney, S. D., Greene, C. S., Radivojac, P.* & Friedberg, I.* (*shared last authors) The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens. Genome Biol (2019) 20, 244, doi:10.1186/s13059-019-1835-8.

2018

2017

2016

2015

2014

2013

2012

2011

2010

2009

2008

  • Adams, B., McHardy, A. C., Lundegard, C. & Lengauer, T. Viral Bioinformatics. In: Modern Genome Annotation, A. Valencia, D. Frishman (Editors), Springer, 2008, 429.
  • Gartemann, K. H., Abt, B., Bekel, T., Burger, A., Engemann, J., Flugel, M., Gaigalat, L., Goesmann, A., Grafen, I., Kalinowski, J., Kaup, O., Kirchner, O., Krause, L., Linke, B., McHardy, A. C., Meyer, F., Pohle, S., Ruckert, C., Schneiker, S., Zellermann, E. M., Puhler, A., Eichenlaub, R., Kaiser, O. & Bartels, D. The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity. J Bacteriol (2008) 190, 2138, doi:10.1128/JB.01595-07.
  • Holland, L. Z., Albalat, R., Azumi, K., Benito-Gutierrez, E., Blow, M. J., Bronner-Fraser, M., Brunet, F., Butts, T., Candiani, S., Dishaw, L. J., Ferrier, D. E., Garcia-Fernandez, J., Gibson-Brown, J. J., Gissi, C., Godzik, A., Hallbook, F., Hirose, D., Hosomichi, K., Ikuta, T., Inoko, H., Kasahara, M., Kasamatsu, J., Kawashima, T., Kimura, A., Kobayashi, M., Kozmik, Z., Kubokawa, K., Laudet, V., Litman, G. W., McHardy, A. C., Meulemans, D., Nonaka, M., Olinski, R. P., Pancer, Z., Pennacchio, L. A., Pestarino, M., Rast, J. P., Rigoutsos, I., Robinson-Rechavi, M., Roch, G., Saiga, H., Sasakura, Y., Satake, M., Satou, Y., Schubert, M., Sherwood, N., Shiina, T., Takatori, N., Tello, J., Vopalensky, P., Wada, S., Xu, A., Ye, Y., Yoshida, K., Yoshizaki, F., Yu, J. K., Zhang, Q., Zmasek, C. M., de Jong, P. J., Osoegawa, K., Putnam, N. H., Rokhsar, D. S., Satoh, N. & Holland, P. W. The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Res (2008) 18, 1100, doi:10.1101/gr.073676.107.
  • Kalyuzhnaya, M. G., Lapidus, A., Ivanova, N., Copeland, A. C., McHardy, A. C., Szeto, E., Salamov, A., Grigoriev, I. V., Suciu, D., Levine, S. R., Markowitz, V. M., Rigoutsos, I., Tringe, S. G., Bruce, D. C., Richardson, P. M., Lidstrom, M. E. & Chistoserdova, L. High-resolution metagenomics targets specific functional types in complex microbial communities. Nat Biotechnol (2008) 26, 1029, doi:10.1038/nbt.1488.
  • McHardy, A. C. Finding genes in genome sequence. Methods Mol Biol (2008) 452, 163, doi:10.1007/978-1-60327-159-2_8.

2007

  • Krause, L.*, McHardy, A. C.*, Nattkemper, T. W., Puhler, A., Stoye, J. & Meyer, F. (*shared first authors) GISMO--gene identification using a support vector machine for ORF classification. Nucleic Acids Res (2007) 35, 540, doi:10.1093/nar/gkl1083.
  • Mavromatis, K., Ivanova, N., Barry, K., Shapiro, H., Goltsman, E., McHardy, A. C., Rigoutsos, I., Salamov, A., Korzeniewski, F., Land, M., Lapidus, A., Grigoriev, I., Richardson, P., Hugenholtz, P. & Kyrpides, N. C. Use of simulated data sets to evaluate the fidelity of metagenomic processing methods. Nat Methods (2007) 4, 495, doi:10.1038/nmeth1043.
  • McHardy, A. C., Martin, H. G., Tsirigos, A., Hugenholtz, P. & Rigoutsos, I. Accurate phylogenetic classification of variable-length DNA fragments. Nat Methods (2007) 4, 63, doi:10.1038/nmeth976.
  • McHardy, A. C. & Rigoutsos, I. What's in the mix: phylogenetic classification of metagenome sequence samples. Curr Opin Microbiol (2007) 10, 499, doi:10.1016/j.mib.2007.08.004.
  • Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M. O., Bartels, D., Bekel, T., Beyer, S., Bode, E., Bode, H. B., Bolten, C. J., Choudhuri, J. V., Doss, S., Elnakady, Y. A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., Gross, F., Jelsbak, L., Jelsbak, L., Kalinowski, J., Kegler, C., Knauber, T., Konietzny, S., Kopp, M., Krause, L., Krug, D., Linke, B., Mahmud, T., Martinez-Arias, R., McHardy, A. C., Merai, M., Meyer, F., Mormann, S., Munoz-Dorado, J., Perez, J., Pradella, S., Rachid, S., Raddatz, G., Rosenau, F., Ruckert, C., Sasse, F., Scharfe, M., Schuster, S. C., Suen, G., Treuner-Lange, A., Velicer, G. J., Vorholter, F. J., Weissman, K. J., Welch, R. D., Wenzel, S. C., Whitworth, D. E., Wilhelm, S., Wittmann, C., Blocker, H., Puhler, A. & Muller, R. Complete genome sequence of the myxobacterium Sorangium cellulosum. Nat Biotechnol (2007) 25, 1281, doi:10.1038/nbt1354.
  • Warnecke, F., Luginbuhl, P., Ivanova, N., Ghassemian, M., Richardson, T. H., Stege, J. T., Cayouette, M., McHardy, A. C., Djordjevic, G., Aboushadi, N., Sorek, R., Tringe, S. G., Podar, M., Martin, H. G., Kunin, V., Dalevi, D., Madejska, J., Kirton, E., Platt, D., Szeto, E., Salamov, A., Barry, K., Mikhailova, N., Kyrpides, N. C., Matson, E. G., Ottesen, E. A., Zhang, X., Hernandez, M., Murillo, C., Acosta, L. G., Rigoutsos, I., Tamayo, G., Green, B. D., Chang, C., Rubin, E. M., Mathur, E. J., Robertson, D. E., Hugenholtz, P. & Leadbetter, J. R. Metagenomic and functional analysis of hindgut microbiota of a wood-feeding higher termite. Nature (2007) 450, 560, doi:10.1038/nature06269.

2006

2005

  • Overbeek, R., Begley, T., Butler, R. M., Choudhuri, J. V., Chuang, H. Y., Cohoon, M., de Crecy-Lagard, V., Diaz, N., Disz, T., Edwards, R., Fonstein, M., Frank, E. D., Gerdes, S., Glass, E. M., Goesmann, A., Hanson, A., Iwata-Reuyl, D., Jensen, R., Jamshidi, N., Krause, L., Kubal, M., Larsen, N., Linke, B., McHardy, A. C., Meyer, F., Neuweger, H., Olsen, G., Olson, R., Osterman, A., Portnoy, V., Pusch, G. D., Rodionov, D. A., Ruckert, C., Steiner, J., Stevens, R., Thiele, I., Vassieva, O., Ye, Y., Zagnitko, O. & Vonstein, V. The subsystems approach to genome annotation and its use in the project to annotate 1000 genomes. Nucleic Acids Res (2005) 33, 5691, doi:10.1093/nar/gki866.
  • Thieme, F., Koebnik, R., Bekel, T., Berger, C., Boch, J., Buttner, D., Caldana, C., Gaigalat, L., Goesmann, A., Kay, S., Kirchner, O., Lanz, C., Linke, B., McHardy, A. C., Meyer, F., Mittenhuber, G., Nies, D. H., Niesbach-Klosgen, U., Patschkowski, T., Ruckert, C., Rupp, O., Schneiker, S., Schuster, S. C., Vorholter, F. J., Weber, E., Puhler, A., Bonas, U., Bartels, D. & Kaiser, O. Insights into genome plasticity and pathogenicity of the plant pathogenic bacterium Xanthomonas campestris pv. vesicatoria revealed by the complete genome sequence. J Bacteriol (2005) 187, 7254, doi:10.1128/JB.187.21.7254-7266.2005.

2004

2003

              

Video

  • Kann man die nächste Grippe-Epidemie vorhersagen?

    Es antwortet Dr. Andreas Bremges, stellv. Abteilungsleiter Bioinformatik der Infektionsforschung am HZI in Braunschweig.

DruckenPer Mail versendenTeilen