Bioengineered microfluidic in vitro test system to study alveolar transport and clearance
The premise of the revolves around the design and integration of a cutting edge bioengineered microfluidic system mimicking critical physiological functions of the cellular makeup of the lungs. Specifically, by reconstituting the human alveolar epithelial barrier in vitro, our pulmonary organ-on-chip analogues will provide an integrative gateway for in vitro analysis of both, transport across the air-blood-barrier into the blood stream as well as uptake and subsequent clearance by alveolar macrophages.
Such model is expected to have significant impact for predictive preclinical testing of advanced aerosol medicines, in healthy as well as in diseased state.
- Biologische Barrieren und Wirkstofftransport- Prof. Dr. Claus-Michael Lehr