Forschungsprojekte (Drittmittel)

Projekt

Innate immunity supports the initiation of germinal centre reactions

The initiation of germinal centre reactions relies on B cells, having seen the native pathogen, and on interaction of B and T cells at the follicular border. However, in cooperation with the groups of Marie Kosco-Vilbois (Geneva, Switzerland) and Kai Toellner (Birmingham, UK), we have shown that factors associated with innate immunity are also critical for germinal centre formation. Toll-like-receptor 4 was required for the proper formation of the follicular dendritic cell network in B cell follicles and, thus, instrumental for B cell mutation and maturation. This finding contributes to medical research on poor immune responses, e.g. after vaccination of the elderly population. 

SIMM members

Alexey Uvarovskii (since 2016 in Heidelberg), Jaber Dehghany, Michael Meyer-Hermann

Publications

Garin* A, Meyer-Hermann* M, Contie M, Figge MT, Buatois V, Gunzer M, Toellner, K-M, Elson G, Kosco-Vilbois MH. Toll-Like Receptor 4 signaling by Follicular Dendritic Cells is pivotal for germinal center onset and affinity maturation, Immunity 33 (2010) 84-95. [*shared first author]

Meyer-Hermann M, Beyer T. The type of seeder cells determines the efficiency of germinal center reactions. Bull Math Biol 66 (2004) 125-141.

Funding

BMBF-eMED: SYSIMIT
The Human Frontier Science Program Organization (HFSP)

    Projektleiter

    Beteiligte Gruppen

    Geldgeber / Förderer

    Sonstige

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