Microboregulators to sort autoimmune disorders, Volkswagen Foundation Experiment!
Autoimmune diseases are severe, unbalanced overreactions of the human immune system against erroneously recognised antigens. These overreactions are frequently accompanied by strong self-reactions towards healthy tissue. Subsequently, loss of physiological regulatory immune mechanisms is leading to disease manifestation. Although some pharmacological approaches are available for some diseases with certain success, a causal approach with long-term improvement is lacking at the moment.
This project aims at developing the first cell-free microboregulatory system exploiting pathogens’ ability to manipulate host immune responses by using microorganism-derived outer membrane vesicles (OMVs).