Global prevalence and time trends of chronic HBV infection
Hepatitis B virus (HBV) infection is a major public health threat worldwide and despite the availability of a highly effective vaccine, continues to be a serious problem. Being a human carcinogen, chronic infection with HBV, as indicated by presence of HBsAg in blood, can cause cirrhosis and primary liver cancer.
The endemicity of HBV has been found to vary greatly among different areas of the world. It is described by the prevalence of HBsAg, i.e. chronic HBV, in the general population of a defined geographical area. Reliable epidemiologic information on chronic HBV is generally not available from routinely collected data, e.g. national surveillance and incidence reporting. Although HBV infection is considered a notifiable infectious disease in most countries, usually incident acute HBV infections or chronic HBV infections among those notified with an acute infection are recorded. Furthermore, surveillance data reflect clinically apparent disease only, which leads to an underestimation, particularly in children, among which over 90% of infections are asymptomatic.
The objective of this work was to provide an evidence-based assessment of the HBV infection problem around the world by creating new estimates of country-specific prevalence of HBV infection and endemicity and to investigate changes over time. This was addressed by means of a systematic identification and assessment of available epidemiologic information on chronic HBV and by means of applying epidemiologic modelling to generate consistent HBV prevalence estimates based on data points obtained from eligible literature for 161 countries. Changes in HBV endemicity over time were assessed by country and discussed in the context of existing and long-standing prevention approaches like HBV vaccination programmes.
- Ott JJ, Horn J, Krause G, Mikolajczyk RT. Time trends of chronic HBV infection over prior decades – A global analysis. J Hepatol 2017, 66: 48-54.
- Ott JJ, Horn J. Changing hepatitis B virus epidemiology in rural China. Correspondence. Lancet Infect Dis 2016, 16:150.
- Schweitzer A, Horn J, Mikolajczyk RT, Krause G, Ott JJ. Worldwide prevalence of chronic hepatitis B virus infection: Estimations based on a systematic review of data published between 1965 and 2013. Lancet 2015, 386: 1546-55.
- World Health Organization (WHO)
- Epidemiologie - Prof. Dr. Gérard Krause
Geldgeber / Förderer