"The Quinolone Signal of Pseudomonas aeruginosa"
Pseudomonas aeruginosa is an opportunistic pathogen that is consistently one of the top five agents responsible for hospital-acquired infections. It also causes chronic, debilitating lung infections in most cystic fibrosis patients. This ubiquitous bacterium utilizes numerous virulence factors to adapt to many different infection sites and many of P. aeruginosa’s virulence factors are controlled via cell-to-cell signals. Our laboratory has focused on the production and effects of one of these signals, the Pseudomonas quinolone signal (PQS). Our studies on this signal have led to the discovery of the genes responsible for its production. We have studied the regulation of the pqsABCDE, phnAB, and pqsR operons and continue to try to understand the factors that control the expression of these genes. We have also learned that anthranilate is a key precursor for PQS and have shown that P. aeruginosa utilizes multiple well-controlled pathways to ensure that a steady supply of anthranilate is available for PQS synthesis. These studies have also led to basic results which indicated that the PQS synthetic pathway could serve as a target for the development of novel drugs that will reduce P. aeruginosa virulence.
Gebäude und Raum
Blg C4 3, Kleiner Hörsaal der Anorganischen Chemie
Prof. Dr. Everett Carl Pesci
Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University
Prof. Dr. Rolf Hartmann