Prof. Dr. Francois Lépine "Quorum sensing: A new pathway for the synthesis of 4-hydroxy-2-alkylquinolines, the signaling molecules of Pseudomonas aeruginosa"

HIPS Talk

  • Überblick

    Summary

    Pseudomonas areuginosa is an ubiquitous Gram negative bacterium. It is also an opportunistic human pathogen which is responsible for many nosocomial infections, especially for patients with immunodeficiencies. It is also the main factor of mortality for patients with cystic fibrosis. This bacterium possesses a vast array of virulence factors, many of which are under the control of quorum sensing. In P. aeruginosa, there are three such quorum sensing systems, one of which is the PQS system (for Pseudomonas Quinolone System). The signaling compounds of the PQS system belong to a family of 4-hydroxy-2-alkylquinolines (HAQ). As we previously shown that inhibiting the biosynthesis of HAQ lead to a decrease of the virulene of the bacteria, we got interested in the biosynthesis of these compounds in an effort to find molecules that could inhibit their production. Although the genes responsible for the production of HAQ have been identified, the role of many of the proteins they encoded had not been determined. In this presentation we will present our findings on the role of these enzymes and the nature of the intermediates that are incorporated into HAQ.

    CV

    Prof. Lépine studied Chemistry at the Université du Québec à Montréal (B.Sc. in Biochemistry and M.Sc in Organic Chemistry) and obtained his PhD in Organic Chemistry at the McGill University, Montreal with Dr B. Belleau in 1985. He worked as a research assistant at the Biomedical Mass Spectrometry Unit at McGill University with Dr. O.A. Mamer and became Professor at the INRS-Institut Armand-Frappier, Laval, Université du Québec in 1987.
    Prof. Lépine is the author of 131 peer review publications in such fields as mass spectrometry, environmental bioremediation, enzymology, biochemistry and microbiology.
    His more recent research interests are in the analytical chemistry of microbial metabolites such as rhamnolipids, siderophores and signaling molecules produced by various bacteria. I am especially interested in the biosynthesis of 4-hydroxy-2-alkylquinolines (HAQ), which are signaling compounds of the opportunistic pathogen Pseudomonas aeruginosa, in an effort to understand their biosynthesis, as inhibition of HAQ production lead to a decrease of the virulence of these bacteria.


    Datum: 01.04.2014, 17:00

    Veranstaltungsort

    Universität des Saarlandes

    Gebäude und Raum

    in Blg C4 3,
    Kleiner Hörsaal der Anorganischen Chemie

    Referent

    Francois Lépine
    INRS-Institut Armand-Frappier,
    Laval Université du Québec

    Gastgeber

    Rolf Hartmann

  • Anfahrt

    So erreichen Sie uns in Saarbrücken

    Das HIPS-Gebäude befindet sich am Osteingang des Saarbrücker Campuses der Universität des Saarlandes. Der Campus liegt vor den Toren der Innenstadt in einem Waldgebiet. Saarbrücken ist die Hauptstadt des Saarlandes, welches im Südwesten Deutschlands liegt und gemeinsame Grenzen mit Frankreich und Luxemburg besitzt.

    Adresse

    Helmholtz-Institut für Pharmazeutische Forschung Saarland (HIPS)
    Universitätscampus E8 1
    66123 Saarbrücken

    Mit dem Auto

    • von Norden (Köln/Trier) über die Autobahnen A1/A8 zum Autobahnkreuz Neunkirchen, dort A6 in Richtung Saarbrücken
    • von Osten (Kaiserslautern) über die A6
    • von Nord-Westen (Luxemburg) über die A620, vorbei am Stadtzentrum auf die A6 in Richtung Mannheim
    • von Westen (Paris/Metz) und Süden (Strasbourg) über die A6/E50 in Richtung Mannheim

    Ausfahrt Nr. 6, "St. Ingbert-West/Universität" der Beschilderung "Universität Ost" folgen (ca. 6 km)

    Mit dem Zug

    • ICE/TGV- und Intercity-Bahnhof Saarbrücken Hbf
    • man kann den Campus mit Öffentlichen Verkehrsmitteln vom Hauptbahnhof (Linien 112, 124) und aus dem Stadtzentrum (Linien 101, 102, 109, 111) innerhalb von ca. 15 min. erreichen

    Downloads

Kontakt

  • Birgitta Lelarge

    Birgitta Lelarge

    Assistentin der Geschäftsführung

    0681 98806-3022

    0681 98806-3003

    Kontakt