HIPS-Talk: "The Quinolone Signal of Pseudomonas aeruginosa"

  • Überblick

    Pseudomonas aeruginosa is an opportunistic pathogen that is consistently one of the top five agents responsible for hospital-acquired infections. It also causes chronic, debilitating lung infections in most cystic fibrosis patients. This ubiquitous bacterium utilizes numerous virulence factors to adapt to many different infection sites and many of P. aeruginosa’s virulence factors are controlled via cell-to-cell signals. Our laboratory has focused on the production and effects of one of these signals, the Pseudomonas quinolone signal (PQS). Our studies on this signal have led to the discovery of the genes responsible for its production. We have studied the regulation of the pqsABCDE, phnAB, and pqsR operons and continue to try to understand the factors that control the expression of these genes. We have also learned that anthranilate is a key precursor for PQS and have shown that P. aeruginosa utilizes multiple well-controlled pathways to ensure that a steady supply of anthranilate is available for PQS synthesis. These studies have also led to basic results which indicated that the PQS synthetic pathway could serve as a target for the development of novel drugs that will reduce P. aeruginosa virulence.


    Datum: 20.10.2015, 17:00

    Veranstaltungsort

    HIPS

    Gebäude und Raum

    Blg E8.1, Conference Room (Ground floor)

    Referent

    Prof. Dr. Everett Carl Pesci
    Department of Microbiology and Immunology
    Brody School of Medicine
    East Carolina University

    Gastgeber

    Prof. Dr. Rolf Hartmann