Gerd Schmitz "Acute and chronic inflammatory responses of the lipidome"
Lipids are central to the regulation and control of cellular processes by acting as basic building units for biomembranes, the platforms for the vast majority of cellular functions. Recent developments in lipid mass spectrometry have set the scene for a completely new way to understand the composition of membranes, cells and tissues in space and time by allowing the precise identification and quantification of alterations of the total lipid profile after specific perturbations. In combination with advanced proteome and transcriptome analysis tools, it is now possible to unravel the complex network between lipids, genes and proteins in an integrated lipidomics approach. Minor lipid species including sterols, oxysterols, steroid hormones, toxic bile acids, polyunsaturated fatty acids, lysophospholipids, plasmalogens, glycerophospholipids and sphingolipids act as mediators and play major roles in cell regulations at the receptor level, through transcription and epigenetic modulation. About 54 G-Protein receptors exist with specific bioactive lipids as ligands regulating, migration, proliferation and defence functions. Many nuclear receptors and transcription initiation complexes need bioactive lipids as chaperones for activation. Recently “immunometabolism” has been defined as a new field of research at the interlink between metabolic overload, sedentary life style (Diabesity) and chronic low level inflammation. The innate immune system is as important for exogenous host defense as well as for the management of endogenous liptoxic/lipoapoptotic molecules in Diabesity. Sphingolipids, lysophospholipids and postanoid species were shown to predict mortality in SIRS, Sepsis and MOF. Lipidomics targets a multiomics approach combining lipid species analysis metabolomics, proteomics, transcriptomics, epigenetics, GWAS and systems health in translational research and health care.
Helmholtzzentrum für Infektionsforschung
Gebäude und Raum
Institute for Clinical Chemistry and Laboratory Medicine
University Hospital Regensburg
Prof. Dr. Mark Brönstrup
- Chemische Biologie - Prof. Dr. Mark Brönstrup