Regulation in Infection Biology

Understanding the pathophysiological events and processes during the onset and progression of infectious diseases is elementary to the development of novel and highly innovative, targeted therapeutics. These therapeutics or anti-infectives can either target critical components of the infective agent, bacteria or viruses, or directly interfere with host (human) innate immune responses and pathways. The team is particularly interested in deciphering how bacterial RNAs and proteins succeed to orchestrate and fine-modulate gene expression at the transcriptional, post-transcriptional and post-translational level. A better insight into these critical regulatory mechanisms could potentially allow for the development of target tailored therapies. A successful example of potential application of our research in biotechnology and medicine is our recent discovery of an RNA programmable genome editing tool (dual-RNA guided DNA cleavage enzyme Cas9) that stems from our analysis of the adaptive immune CRISPR-Cas system in bacterial pathogens.

Emmanuelle Charpentier's Department is affiliated to the Laboratory for Molecular Infection Medicine Sweden (MIMS) at the Department of Molecular biology of Umea University. The Department is also affiliated to the Hannover Medical School (MHH)

Prof. Dr. Emmanuelle Charpentier

„Our research program focuses on mechanisms of regulation in infection and immunity. We want to understand how RNA and protein molecules work and cooperate to control gene expression and biological processes in bacterial pathogens.“

Emmanuelle Charpentier studied biochemistry and microbiology at the University Pierre and Marie Curie, Paris, France where she received her PhD in Microbiology for her research performed at the Pasteur Institute. She then moved to the United States, where she held Research Associate positions at the Rockefeller University, New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York, NY) and at St Jude Children’s Research Hospital (in Memphis, TN). Emmanuelle Charpentier returned to Europe to establish her own research group at the Max F. Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology. She was then recruited as an Associate Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS, Swedish Node of the European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umeå University. In 2012 Emmanuelle Charpentier was appointed Professor at Hannover Medical School (MHH) and head of the department “Regulation in Infection Biology” at the HZI. In 2013, Emmanuelle was awarded an Alexander von Humboldt Professorship.

Leader

  • Prof Dr Emmanuelle Charpentier

    Emmanuelle Charpentier

    Head of the Department Regulation in Infection Biology

    +49 531 6181-5500

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Bachelor, Master and PhD Theses

Are you interested in joining our research group?

We are constantly looking for highly motivated and enthusiastic bachelor and master students, PhD students and Post-docs who would like to join our team. Please contact directly Emmanuelle Charpentier for more information. The Department is a host lab for Alexander von Humboldt fellows: please have a look at the website http://www.humboldt-foundation.de/web/home.html. We are looking forward to your application!