Regulation in Infection Biology

Our research relates to the field of Molecular Infection Biology. We are principally interested in understanding the molecular mechanisms governing physiology and infection-associated processes in Gram-positive bacterial pathogens. We use a combination of genetic, genomic, molecular, biochemical, physiological and cell infection approaches to study mechanisms of gene expression at the transcriptional and post-transcriptional level in horizontal gene transfer, adaptation to stress, physiology or virulence. In particular, we do research on CRISPR, the adaptive immune system that protects bacteria against invading genetic elements; the small regulatory RNAs that interfere with bacterial pathogenicity; protein quality-control that regulates bacterial adaptation, physiology and virulence; and the mechanisms of bacterial recognition by immune cells.

Note: The Department is relocating to the Max Planck Institute for Infection Biology in Berlin!

Emmanuelle Charpentier's Department is affiliated to the Hannover Medical School (MHH) and the Laboratory for Molecular Infection Medicine Sweden (MIMS) at the Department of Molecular Biology of Umeå University.

Prof. Dr. Emmanuelle Charpentier

„Our research program focuses on mechanisms of regulation in infection and immunity. We want to understand how RNA and protein molecules work and cooperate to control gene expression and biological processes in bacterial pathogens.“

© Hallbauer & Fioretti

Emmanuelle Charpentier studied biochemistry, microbiology and genetics at the University Pierre and Marie Curie, Paris, France and obtained her PhD in Microbiology for her research performed at the Pasteur Institute. She then continued her work in the United States, at The Rockefeller University, New York University Langone Medical Center and the Skirball Institute of Biomolecular Medicine (all in New York, NY) and at St Jude Children's Research Hospital (in Memphis, TN). Emmanuelle returned to Europe to establish her own research group at the Max F. Perutz Laboratories of the University of Vienna in Austria where she habilitated in the field of Microbiology. She was then appointed Associate Professor and then Guest Professor at the Laboratory for Molecular Infection Medicine Sweden (MIMS, part of Nordic European Molecular Biology Laboratory (EMBL) Partnership for Molecular Medicine) at Umeå University in Sweden where she habilitated in the field of Medical Microbiology. Since 2013, Emmanuelle is also Head of the Department "Regulation in Infection Biology" at the Helmholtz Centre for Infection Research, and Professor at the Medical School of Hannover in Germany. The same year, she was awarded an Alexander von Humboldt Professorship, which she has held since 2014. In 2015, Emmanuelle was appointed Scientific Member of the Max Planck Society in Germany and Director at the Max Planck Institute for Infection Biology in Berlin.

Emmanuelle is recognized as a world-leading expert in regulatory mechanisms underlying processes of infection and immunity in bacterial pathogens. With her recent groundbreaking findings in the field of RNA-mediated regulation based on the CRISPR-Cas9 system, Emmanuelle has laid the foundation for the development of a novel, highly versatile and specific genome editing tool that is revolutionizing life sciences research and could open up whole new opportunities in biomedical gene therapies. The resulting field of research is now developing at dazzling speed, with exciting new aspects emerging almost weekly. Emmanuelle has been awarded prestigious honors. Emmanuelle is co-inventor and co-owner of seminal intellectual property comprising the CRISPR-Cas9 technology, and scientific founder of CRISPR Therapeutics and ERS Genomics, created to enable the development of the CRISPR-Cas9 genome engineering technology for biotechnological and biomedical applications.


  • Prof Dr Emmanuelle Charpentier


    Head of the Department Regulation in Infection Biology

    +49 531 6181-5500



Are you interested in joining our research group?

Are you interested in joining our research group? We are constantly looking for highly motivated and enthusiastic bachelor and master students, PhD students and Post docs who would like to join our affiliated Department of Regulation in Infection Biology (RIIB) at the Max Planck Institute for Infection Biology (MPIIB) in Berlin. Please see here for more information. The Department is a host lab Alexander von Humboldt fellows: please have a look at the website for more information. We are looking forward to your application!