Selected publications as a main author

17.     Herrmann S, Siegl T, Luzhetska M, Petzke L, Jilg C, Welle E, Erb A, Leadlay PF, Bechthold A, Luzhetskyy A. Site-specific recombination strategies for engineering actinomycete genomes.  Appl Environ Microbiol. 2012 in press 

16.     Myronovskyi M, Welle E, Fedorenko V, Luzhetskyy A. Beta-glucuronidase as a sensitive and versatile reporter in actinomycetes. Appl Environ Microbiol. 2011. Vol.77. P.5370-5383.

15.      Siegl T., Petzke L., Welle E., and Luzhetskyy A*. I-SceI endonuclease: a new tool for DNA repair studies and genetic manipulations in streptomyces. Appl Microbiol Biotechnol. 2010. Vol. 87. P.1525-1532.

14.     Petzke L and Luzhetskyy A*. In vivo Tn5-based transposon mutagenesis of Streptomycetes. Appl Microbiol Biotechnol. 2009. Vol.83. P. 979-986.

13.     Fedoryshyn M., Petzke L., Welle E., Bechthold A., Luzhetskyy A*. Marker removal from actinomycetes genome using Flp recombinase. Gene. 2008. Vol.419. P. 43-47.

12.    Fedoryshyn M., Welle E., Bechthold A., Luzhetskyy A*. Functional expression of the cre recombinase in actinomycetes. Appl Microbiol Biotechnol. 2008. Vol.78. P. 1065-1070.

11.    Luzhetskyy A*., Hoffman J., Pelzer S., Wohlert S., Vente A., Bechthold A. Aranciamycin analogues generated by combinatorial biosynthesis show improved antitumor activity. Appl Microbiol Biotechnol. 2008. doi:10.1007/s00253-008-1515-1.

10.    Luzhetskyy A*., Weiss H., Charge A., Welle E., Linennbrink A., Bechthold A. A strategy for cloning glycosyltransferase genes involved in natural product biosynthesis. Appl Microbiol Biotechnol. 2007. Vol.75. P. 1367-1375.

9.     Luzhetskyy A*., Mayer A., Hoffmann J., Pelzer S., Wohlert S., Vente A., Bechthold A. Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase. Chembiochem. 2007. Vol.8. P. 599-602.

8.     Luzhetskyy A., Fedoryshyn M., Gromyko O., Ostash B., Rebets Y., Bechthold A., Fedorenko V. IncP plasmids are most effective in mediating conjugation between Escherichia coli and streptomycetes. Genetika. 2006. Vol.42 (5). P.476-481.

7.   Luzhetskyy A*., Bechthold A. It works: Combinatorial biosynthesis, an undeniable way for the generation of novel glycosylated compounds. MolMicrobiol. 2005. Vol.58 (3), 3-5.

6.   Luzhetskyy A*., Taguchi T, Fedoryshyn M, Dürr C, Wohlert SE, Novikov V, Bechthold A. LanGT2 catalyzes the first glycosylation step during landomycin A biosynthesis. Chembiochem. 2005. Vol.6. (8), P.1406-1410.

5.   Luzhetskyy A*., Fedoryshyn M, Dürr C, Taguchi T, Novikov V, Bechthold A. Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A. Chembiol. 2005. Vol.12 (7), P.725-729.

4.   Luzhetskyy A., Zhu L., Gibson M., Fedoryshyn M., Dürr C., Hofmann C., Hoffmeister D.,  Ostash B., Mattingly C., Adams V., Fedorenko V., Rohr J., and Bechthold A. Generation of Novel Landomycins M and O Through Targeted Gene Disruption. ChembioChem. 2005. Vol.4, P.675-678.

3.   Luzhetskyy A., Liu T., Fedoryshyn M., Ostash B., Fedorenko V., Rohr J., Bechthold A. Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis. Chembiochem. 2004. Vol.5, N11, P.1567-1570.

2.   Luzhetskyy A., Fedoryshyn M., Hoffmeister D., Bechthold A., Fedorenko V. Gene cloning system for Streptomyces cyanogenus S136 // Visn.Lviv.Univ. 2002. Vol.29, P.62-68.

1.   Luzhetskyy A., Ostash B., Fedorenko V. Interspecies conjugation of Escherichia coli-Streptomyces globisporus 1912 using integrative plasmid pSET152 and its derivatives. Genetika. 2001. Vol.37, N10, P.1340-1347.

Reviews and Book Chapters

7.      Luzhetskyy A*., Pelzer S., Bechthold A. The future of natural products as a source of new antibiotics. Curr Opin Investig Drugs. 2007. Vol. 8. P. 608-613.

6.      Luzhetskyy A*, Vente A, Bechthold A. Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides. Mol.Biosyst. 2005. P.117-126.

5.      Luzhetskyy A*., Mendez C., Salas JA., Bechthold A. Glycosyltransferases, important tools for drug design. Curr Topics Med Chem. 2008. Vol.8. P. 680-709.

4.      Luzhetskyy A* and Bechthold A. Features and applications of bacterial glycosyltransferases: current state and prospects. Appl Microbiol Biotechnol. 2008. Vol. 6. P. 945-952.

3.      Hertweck C., Luzhetskyy A*., Rebets Y., Bechthold A.

2.      Mendez C., Luzhetskyy A*., Bechthold A., Salas JA. Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern. Curr Topics Med Chem. 2007. Vol.8. P. 710-724.

1.      Bechthold A, Weitnauer G, Luzhetskyy A*., Berner M, Bihlmeier C, Boll R, Durr C, Frerich A, Hofmann C, Mayer A, Treede I, Vente A, Luzhetska M. Glycosyltransferases and other tailoring enzymes as tools for the generation of novel compounds. Ernst Schering Res Found Workshop. 2005. P.147-163.

Selected publications as a co-author

11.    Horbal L, Rebets Y, Rabyk M, Makitrynskyy R, Luzhetskyy A, Fedorenko V, Bechthold A. SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors. AMB Express. 2012, 2(1):1.

10.     Härle J, Günther S, Lauinger B, Weber M, Kammerer B, Zechel DL, Luzhetskyy A, Bechthold A. Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase. 2011. Vol.18. P.520-530.

9.      Erb A, Luzhetskyy A*., Hardter U, Bechthold A. Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and elucidating the assembly of their saccharide chains. ChemBioChem. 2009. Vol.8: 1392-1401

8.      Krauth C, Fedoryshyn M, Schleberger C, Luzhetskyy A*., Bechthold A. Engineering a function into a glycosyltransferase. Chem Biol. 2009. Vol.16. P. 28-35.

7.      Zhu L., Luzhetskyy A*., Luzhetska M., Mattingly C., Adams V., Bechthold A., Rohr J. Generation of New Landomycins with Altered Saccharide Patterns through Over-expression of the Glycosyltransferase Gene lanGT3 in the Biosynthetic Gene Cluster of Landomycin A in Streptomyces cyanogenus S-136. Chembiochem. 2007. Vol.8(1). P.83-88.

6.      Dürr C., Schnell H.-J., Luzhetskyy A*., Murillo R., Weber M., Welzel K., Vente A., Bechthold A. Biosynthesis of the Terpene Antibiotic Phenalinolactone in Streptomyces sp. Tü6071: Functional Analysis of the Gene Cluster and Generation of Novel Derivatives. Chembiol. 2006. Vol.13. P.365-377.

5.      Ostash B., Rix U., Rix L., Liu T., Lombo F., Luzhetskyy A., Gromyko O., Wang C., Brana A., Mendez C., Salas J.A., Fedorenko V., Rohr J. Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus. Chem Biol. 2004 Vol.11, N4, P.547-555.

4.      Rebets Y., Ostash B., Luzhetskyy A., Hoffmeister D., Brana A., Mendez C., Salas J., Bechthold A., Fedorenko V. Production of landomycins in Streptomyces globisporus 1912 and S cyanogenus S136 is regulated by genes encoding putative transcriptional activators. FEMS Microbiol Lett. 2003. Vol.222, N1, P.149-153.

3.     Mulert U., Luzhetskyy A*., Hofmann C., Mayer A., Bechthold A. Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene. FEMS Microbiol Lett. 2004. Vol.230, N1, P.91-97.       

2.     Zhu L., Ostash B., Rix U., Nur-E-Alam M., Mayer A., Luzhetskyy A., Mendez C., Salas JA., Bechthold A., Fedorenko V., Rohr J.  Identification of the Function of Gene lndM2 Encoding a Bifunctional Oxygenase-Reductase Involved in the Biosynthesis of the Antitumor Antibiotic Landomycin E by Streptomyces globisporus 1912 Supports the Originally Assigned Structure for Landomycinone. J Org Chem. 2005. Vol.70, N2, P.631-638.

1.     Baig I., Kharel M., Kobylyanskyy A., Zhu L., Rebets Y., Ostash B., Luzhetskyy A., Bechthold A.,  Fedorenko V., Rohr J. On the Acceptor Substrate of C-Glycosyltransferase UrdGT2: Three Prejadomycin C-Glycosides from an Engineered Mutant of Streptomyces globisporus 1912 DlndE(urdGT2). Angewandte Chemie Int. Ed. 2006. Vol. 45(46). P.7842-7846.