The cytoskeleton plays an important role in motility and host cell entry of pathogens. The cytoskeleton - the skeleton of the cell - is neither made of bone nor rigid, but a flexible mesh of proteins – one of the most important components being actin. How can we interfere with the cytoskeleton of a pathogen? How do these proteins recognize each other and work together to enable motility, host cell recognition, and invasion? It is questions like these that our scientists at the interdisciplinary Centre for Structural Systems Biology (CSSB) aim to find answers to - using “super microscopes”, such as PETRA III, FLASH, and XFEL at DESY in Hamburg.