Helmholtz-Zentrum für Infektionsforschung

Helmholtz-Zentrum für Infektionsforschung

Selected Publications

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Miyao, T., S. Floess, R. Setoguchi, H. Luche, H.J. Fehling, H. Waldmann, J. Huehn, S. Hori; (2012). ExFoxp3 helper T cells reflect promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity:, doi:10.1016/j.immuni.2011.12.012 PubMed

Mayer,C.T.; Floess,S.; Baru,A.M.; Lahl,K.; Hühn,Jochen*; Sparwasser,T.; (2011). CD8(+) Foxp3(+) T cells share developmental and phenotypic features with classical CD4(+) Foxp3(+) regulatory T cells but lack potent suppressive activity. European Journal of Immunology: 41 3, 716-725

Steinfelder,S.; Floess,S.; Engelbert,D.; Haeringer,B.; Baron,U.; Rivino,L.; Steckel,B.; Gruetzkau,A.; Olek,S.; Geginat,J.; Hühn,Jochen*; Hamann,A.; (2011). Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells. Blood: 117 10, 2839-2846

Blankenhaus,B.; Klemm,U.; Eschbach,M.L.; Sparwasser,T.; Hühn,Jochen*; Kuhl,A.A.; Loddenkemper,C.; Jacobs,T.; Breloer,M.; (2011). Strongyloides ratti infection induces expansion of Foxp3(+) regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice. Journal of Immunology: 186 7, 4295-4305

Toker,A.; Hühn,Jochen*; (2011). To be or not to be a Treg cell: lineage decisions controlled by epigenetic mechanisms. Science Signaling: 4 158, e4 HZI repository PubMed

Hubert,S.; Rissiek,B.; Klages,K.; Hühn,Jochen*; Sparwasser,T.; Haag,F.; Koch-Nolte,F.; Boyer,O.; Seman,M.; Adriouch,S.; (2010). Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. Journal of Experimental Medicine: 207 12, 2561-2568 HZI repository PubMed

Polansky,J.K.; Schreiber,L.; Thelemann,C.; Ludwig,L.; Kruger,M.; Baumgrass,R.; Cording,S.; Floess,S.; Hamann,A.; Hühn,Jochen*; (2010). Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells. Journal of Molecular Medicine: 88 10, 1029-1040

Menning,A.; Loddenkemper,C.; Westendorf,A.M.; Szilagyi,B.; Buer,J.; Siewert,C.; Hamann,A.; Hühn,Jochen*; (2010). Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation. European Journal of Immunology: 40 9, 2539-2548

Klages,K.; Mayer,C.T.; Lahl,K.; Loddenkemper,C.; Teng,M.W.; Ngiow,S.F.; Smyth,M.J.; Hamann,A.; Hühn,Jochen*; Sparwasser,T.; (2010). Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Research: 70 20, 7788-7799

Koenecke,C.; Czeloth,N.; Bubke,A.; Schmitz,S.; Kissenpfennig,A.; Malissen,B.; Hühn,Jochen*; Ganser,A.; Forster,R.; Prinz,I.; (2009). Alloantigen-specific de novo-induced Foxp3(+) Treg revert in vivo and do not protect from experimental GVHD. European Journal of Immunology: 39 11, 3091-3096

Hühn,Jochen*; Polansky,J.K.; Hamann,A.; (2009). Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?. Nature Reviews Immunology: 9 2, 83-89

Rausch,S.; Hühn,Jochen*; Loddenkemper,C.; Hepworth,M.R.; Klotz,C.; Sparwasser,T.; Hamann,A.; Lucius,R.; Hartmann,S.; (2009). Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3(+) cells. Europen Journal of Immunology: 39 11, 3066-3077

Hoffmann,P.; Boeld,T.J.; Eder,R.; Hühn,Jochen*; Floess,S.; Wieczorek,G.; Olek,S.; Dietmaier,W.; Andreesen,R.; Edinger,M.; (2009). Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. European Journal of Immunology: 39 4, 1088-1097

Wieczorek,G.; Asemissen,A.; Model,F.; Turbachova,I.; Floess,S.; Liebenberg,V.; Baron,U.; Stauch,D.; Kotsch,K.; Pratschke,J.; Hamann,A.; Loddenkemper,C.; Stein,H.; Volk,H.D.; Hoffmuller,U.; Grutzkau,A.; Mustea,A.; Hühn,Jochen*; Scheibenbogen,C.; Olek,S.; (2009). Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue. Cancer Research: 69 2, 599-608

Polansky,J.K.; Kretschmer,K.; Freyer,J.; Floess,S.; Garbe,A.; Baron,U.; Olek,S.; Hamann,A.; von,Boehmer H.; Hühn,Jochen*; (2008). DNA methylation controls Foxp3 gene expression. European Journal of Immunology: 38 6, 1654-1663

Siewert,C.; Lauer,U.; Cording,S.; Bopp,T.; Schmitt,E.; Hamann,A.; Hühn,Jochen*; (2008). Experience-driven development: effector/memory-like alphaE+Foxp3+ regulatory T cells originate from both naive T cells and naturally occurring naive-like regulatory T cells. Journal of Immunology: 180 1, 146-155

Rausch,S.; Hühn,Jochen*; Kirchhoff,D.; Rzepecka,J.; Schnoeller,C.; Pillai,S.; Loddenkemper,C.; Scheffold,A.; Hamann,A.; Lucius,R.; Hartmann,S.; (2008). Functional analysis of effector and regulatory T cells in a parasitic nematode infection. Infection and Immunity: 76 5, 1908-1919

Baron,U.; Floess,S.; Wieczorek,G.; Baumann,K.; Grutzkau,A.; Dong,J.; Thiel,A.; Boeld,T.J.; Hoffmann,P.; Edinger,M.; Turbachova,I.; Hamann,A.; Olek,S.; Hühn,Jochen*; (2007). DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. European Journal of Immunology: 37 9, 2378-2389 HZI repository PubMed

Lahl,K.; Loddenkemper,C.; Drouin,C.; Freyer,J.; Arnason,J.; Eberl,G.; Hamann,A.; Wagner,H.; Hühn,Jochen*; Sparwasser,T.; (2007). Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. Journal of Experimental Medicine: 204 1, 57-63

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25.05.2012