Many clinically relevant questions and problems are based on processes that are induced and/or maintained by the immune system (e.g. autoimmunity, transplantation immunology, tumor immunology and immunology of infectious diseases).
In order to understand the physiology and pathophysiology of the immune system it is necessary to decode the molecular events and the subcellular structures hat are involved in the induction, maintenance and termination an immune response.
The elucidation of these questions is also of importance for developing new strategies allowing diagnosis and therapy of diseases that involve immunological mechanisms.