The HZI headquarter is located in Braunschweig where it was founded in 1965.
The majority of the approximately 750 employees in Braunschweig are researchers, but management, administration and staff units are also hosted here.
Since 2009 the HZI has a branch in Saarbrücken: the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) with its research on natural products, their chemical optimisation and investigation of biological barriers.
The Twincore in Hannover has been founded jointly by the HZI and the Hanover Medical School (MHH). At Twincore medical personnel and basic research scientists from various disciplines conduct infection research side by side. The focus is upon translational research, the interface between basic research and clinical development.