The focus of our work is the study and investigation of pathogens which are medically relevant or can be used as models for researching infection mechanisms.
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Around 700 employees in research, administration and infrastructure, and about 140 visiting scientists from 40 different countries are employed at the Helmholtz Centre for Infection Research.
Our scientists pursue research to expand our knowledge of the fundamental mechanisms behind medically relevant infectious diseases.
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How do bacteria, viruses, parasites and fungi make us sick? How does our immune system defend our body?
These are the questions we at the HZI want to answer. Our goal: To set up the basis for new diagnostic tools, new active agents and new therapies against infectious diseases.
19.12.2012, 17:15 - HZI-Kolloquium - Scientific
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous subset of myeloid cells with an immature phenotype and T cell-suppressive functions. Under steady-state conditions they are lacking the suppressive activity and are called immature myeloid cells (IMCs). In the mouse two major subsets have been defined: granulocytic and monocytic MDSCs. However, the difference of the latter subset to monocytes has not been defined yet. Our data suggest that GM-CSF "licensing" of monocytes marks their conversion to IMC in order to respond to further LPS/IFN-γ activation. MDSC activation can also strongly be induced by mycobacteria. Our results indicate new survival and immune escape strategies by Mtb by hiding in caveolae of MDSC but simultaneously expand and activate them for immune suppression of T cell responses.
Helmholtz Centre for Infection ResearchInhoffenstraße 738124 Braunschweig+49 531 email@example.com
Helmholtz Institute for Pharmaceutical Research SaarlandCampus, Geb. C2.3Universität des Saarlandes66123 Saarbrücken+49 681 firstname.lastname@example.org
TWINCOREZentrum für Experimentelle und Klinische InfektionsforschungFeodor-Lynen-Str. 730625 Hannover+49 511 email@example.com
Study Centre HannoverFeodor-Lynen-Straße 530625 Hannover+49 511 firstname.lastname@example.org