The focus of our work is the study and investigation of pathogens which are medically relevant or can be used as models for researching infection mechanisms.
To the research topics
Around 700 employees in research, administration and infrastructure, and about 140 visiting scientists from 40 different countries are employed at the Helmholtz Centre for Infection Research.
Our scientists pursue research to expand our knowledge of the fundamental mechanisms behind medically relevant infectious diseases.
To the open positions
World Class research demands concentrated and focused support. To be internationally successful, adequate financial resources and a supportive environment are both important. This applies also to the Helmholtz Centre for Infection Research (HZI).
The Friends of the Helmholtz-Centre for Infection Research made it their business to support important activities of the centre. This concerns among others the results of basic research that is developed further to medical application.
19.12.2012, 17:15 - HZI-Kolloquium - Scientific
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous subset of myeloid cells with an immature phenotype and T cell-suppressive functions. Under steady-state conditions they are lacking the suppressive activity and are called immature myeloid cells (IMCs). In the mouse two major subsets have been defined: granulocytic and monocytic MDSCs. However, the difference of the latter subset to monocytes has not been defined yet. Our data suggest that GM-CSF "licensing" of monocytes marks their conversion to IMC in order to respond to further LPS/IFN-γ activation. MDSC activation can also strongly be induced by mycobacteria. Our results indicate new survival and immune escape strategies by Mtb by hiding in caveolae of MDSC but simultaneously expand and activate them for immune suppression of T cell responses.
Helmholtz Centre for Infection ResearchInhoffenstraße 738124 Braunschweig+49 531 firstname.lastname@example.org
Helmholtz Institute for Pharmaceutical Research SaarlandCampus, Geb. C2.3Universität des Saarlandes66123 Saarbrücken+49 681 email@example.com
TWINCOREZentrum für Experimentelle und Klinische InfektionsforschungFeodor-Lynen-Str. 730625 Hannover+49 511 firstname.lastname@example.org
Study Centre HannoverFeodor-Lynen-Straße 1530625 Hannover+49 511 5350 email@example.com