Helmholtz Centre for Infection Research
Tasks:
- Coordination & project management
- Virulence expression profiling of the isolates
- design of protein arrays
- identification of region-specific vaccine candidates and testing their efficacy
Project coordinator:
Prof. Dr. G. S. Chhatwal
HZI- Helmholtz Centre for Infection Research
Dept. Microbiology
Inhoffenstr. 7
D 38124 Braunschweig
Germany
e-mail: gsc@helmholtz-hzi.de
Team Members:
Dr. Andreas Nerlich, e-mail: Andreas.Nerlich@helmholtz-hzi.de
Dr. Vivek Sagar, e-mail: Vivek.Sagar@helmholtz-hzi.de
Rene Bergmann, e-mail: Rene.Bergmann@helmholtz-hzi.de
Post Graduate Insitute of Medical Education and Research
Tasks:
- Setting up school-level survey for streptococcal carriage and pharyngitis in defined areas near Chandigarh, North India
- Setting up surveillance for acute rheumatic fever and rheumatic heart disease in hospitals of survey area
- Establishing of surveillance for invasive strep disease in tertiary care hospitals of Chandigarh
Project Participant:
Prof. Dr. K. K. Talwar
Dept. of Cardiology
Post Graduate Institute of Medical Education and Research (PGIMER)
Chandigarh - 160 012
India
Tel. 0091-172-274-5062
Fax 0091-172-274-4401
e-mail: kktalwar@sancharnet.in
Christian Medical College
Tasks:
- Establishment of a school survey system for the isolation, identification and characterization of GAS strains causing throat and skin infections in a highly endemic community
- Establishment of a Registry for GAS disease and the strains causing them in a highly endemic south Indian community of school going children
- Establishment of a hospital based Registry for GAS invasive disease in South India to determine their prevalence and the nature of strains causing them
Project Participant:
Prof. K. Brahmadathan
Dept. of Microbiology
Christian Medical College (CMC)
Vellore – 632 004
India
Tel. 0091-416-228-3085
Fax 0091-416-223-2103
e-mail: knb1948@hotmail.com
Karolinska Institute
Tasks:
- Comparison of the nature of invasive streptococcal disease in relation to European data
- Determination of host-pathogen interplay at the local site of infection
- Determination of host humoral immunity in relation to disease manifestation
- Identification of molecular mechanisms of streptococcal invasive diseases in India
Project Participant:
Prof. Anna Norrby-Teglund
Dept. of Medicine
Karolinska Institutet (KI)
SE-14186 Stockholm
Sweden
Tel. 0046-858-87296
Fax 0046-8746-7637
e-mail: Anna.Norrby-Teglund@ki.se
All India Institute of Medical Sciences
Tasks:
- Establishing parameters of disease susceptibility in two patient cohorts with different ethnic backgrounds
- Comparison of the disease associated MHC haplotypes between invasive disease and patients with rheumatic fever/ rheumatic heart disease
- Understanding molecular mechanisms of genetic predisposition in streptococcal disease in India
Project Participant:
Prof. Dr. N. K. Mehra
Dept. of Transplant Immunology and Immunogenetics
All India Institute of Medical Sciences (AIIMS)
Ansari Nagar
New Delhi – 110 029
India
Tel. 0091-11-265-88588
Fax 0091-11-265-88663
e-mail: narin98@hotmail.com
University of St. Andrews
Tasks:
- Analysis of the interaction of collagens with streptococcal surface components to select candidates for structural studies
- structural analysis of collagen binding to streptococcal peptides
- design and development of a fast diagnostic prototype assay for rheumatogenic streptococci based on collagen aggregation
Project Participant:
Dr. U. Schwarz-Linek
Centre for Biomolecular Sciences
University of St. Andrews
St Andrews – KY16 9AJ
United Kingdom
Tel. 0044-1334-463401
e-mail: us6@st-andrews.ac.uk