Helmholtz-Zentrum für Infektionsforschung

Helmholtz-Zentrum für Infektionsforschung

Publikationen der Arbeitsgruppe

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Chen,R.; John,J.; Lavrentieva,A.; Müller,S.; Tomala,M.; Zhao,Y.; Zweigerdt,R.; Beutel,S.; Hitzmann,B.; Kasper,C.; Martin,U.; Rinas,Ursula*; Stahl,F.; Scheper,T.; (2012). Cytokine production using membrane adsorbers: Human basic fibroblast growth factor produced by Escherichia coli. Engineering in Live Sciences: 12 1, 29-38

Endres,S.; Hiebl,B.; Hägele,J.; Beltzer,C.; Fuhrmann,R.; Jäger,Volker*; Almeida,M.; Costa,E.; Santos,C.; Traupe,H.; Jung,E.M.; Prantl,L.; Jung,F.; Wilkea,A.; Franke,R.-P.; (2012). Erratum: Angiogenesis and healing with non-shrinking, fast degradeable PLGA/CaP scaffolds in critical-sized defects in the rabbit femur with or without osteogenically induced mesenchymal stem cells (Clinical Hemorheology and Microcirculation (2011) 48:1 (. Clinical Hemorheology and Microcirculation: 49 1-4, 551

Vazquez,E.; Corchero,J.L.; Burgueno,J.F.; Seras-Franzoso,J.; Kosoy,A.; Bosser,R.; Mendoza,R.; Martinez-Lainez,J.M.; Rinas,Ursula*; Fernandez,E.; Ruiz-Avila,L.; Garcia-Fruitos,E.; Villaverde,A.; (2012). Functional inclusion bodies produced in bacteria as naturally occurring nanopills for advanced cell therapies. Advanced Materials: 24 13, 1742-1747

Sans,C.; Garcia-Fruitos,E.; Ferraz,R.M.; Gonzalez-Montalban,N.; Rinas,Ursula*; Lopez-Santin,J.; Villaverde,A.; Alvaro,G.; (2012). Inclusion bodies of fuculose-1-phosphate aldolase as stable and reusable biocatalysts13741. Biotechnology progress: 28 2, 421-427

Buschart,A.; Gremmer,K.; El-Mowafy,M.; van den,Heuvel Joop*; Müller,Peter P*.; Bilitewski,Ursula*; (2011). A novel functional assay for fungal histidine kinases group III reveals the role of HAMP domains for fungicide sensitivity. Journal of Biotechnology: 157 1, 268-277

Schmidt,G.; Krings,U.; Nimtz,Manfred*; Berger,R.G.; (2011). A surfactant tolerant laccase of Meripilus giganteus 3685. World Journal of Microbiology and Biotechnology: 28 4, 1623-1632

Endres,S.; Hiebl,B.; Hagele,J.; Beltzer,C.; Fuhrmann,R.; Jäger,Volker*; Almeida,M.; Costa,E.; Santos,C.; Traupe,H.; Jung,E.M.; Prantl,L.; Jung,F.; Wilke,A.; Franke,R.P.; (2011). Angiogenesis and healing with non-shrinking, fast degradeable PLGA/CaP scaffolds in critical-sized defects in the rabbit femur with or without osteogenically induced mesenchymal stem cells. Clinical Hemorheology and Microcirculation: 48 1, 29-40

Bals,C.; Schambach,A.; Meyer,J.; Scheper,T.; Rinas,Ursula*; (2011). Expression and purification of bioactive soluble murine stem cell factor from recombinant Escherichia coli using thioredoxin as fusion partner. Journal of Biotechnology: 152 1-2, 1-8 HZI-Repositorium PubMed

Busso,D.; Peleg,Y.; Heidebrecht,T.; Romier,C.; Jacobovitch,Y.; Dantes,A.; Salim,L.; Troesch,E.; Schuetz,A.; Heinemann,U.; Folkers,G.E.; Geerlof,A.; Wilmanns,M.; Polewacz,A.; Quedenau,C.; Bussow,Konrad*; Adamson,R.; Blagova,E.; Walton,J.; Cartwright,J.L.; Bird,L.E.; Owens,R.J.; Berrow,N.S.; Wilson,K.S.; Sussman,J.L.; Perrakis,A.; Celie,P.H.; (2011). Expression of protein complexes using multiple Escherichia coli protein co-expression systems: A benchmarking study. Journal of Structural Biology: 175 2, 159-170 HZI-Repositorium PubMed

Ergin,A.; Syrbe,U.; Scheer,R.; Thiel,A.; Adam,T.; Büssow,Konrad*; Duchmann,R.; Zeitz,M.; Sieper,J.; (2011). Impaired Peripheral Th1 CD4+ T Cell Response to Escherichia coli Proteins in Patients with Crohn's Disease and Ankylosing Spondylitis3529. Journal of Clinial Immunology: 31 6, 998-1009

Gohler,A.K.; Kokpinar,O.; Schmidt-Heck,W.; Geffers,Robert*; Guthke,R.; Rinas,Ursula*; Schuster,S.; Jahreis,K.; Kaleta,C.; (2011). More than just a metabolic regulator - elucidation and validation of new targets of PdhR in Escherichia coli1. BMC Systems Biology: 5, 197

Jain,G.; Jayaraman,G.; Kökpinar,O.; Rinas,Ursula*; Hitzmann,B.; (2011). On-line monitoring of recombinant bacterial cultures using multi-wavelength fluorescence spectroscopy. Biochemical Engineering Journal: 58-59 1, 133-139

Li,Z.; Nimtz,Manfred*; Rinas,Ursula*; (2011). Optimized procedure to generate heavy isotope and selenomethionine-labeled proteins for structure determination using Escherichia coli-based expression systems. Applied Microbiology and Biotechnology: 92 4, 823-833 HZI-Repositorium PubMed

Gueorguieva,L.; Palani,S.; Rinas,Ursula*; Jayaraman,G.; Seidel-Morgenstern,A.; (2011). Recombinant protein purification using gradient assisted simulated moving bed hydrophobic interaction chromatography. Part II: Process design and experimental validation. Journal of Chromatography A: 1218 37, 6402-6411

Palani,S.; Gueorguieva,L.; Rinas,Ursula*; Seidel-Morgenstern,A.; Jayaraman,G.; (2011). Recombinant protein purification using gradient-assisted simulated moving bed hydrophobic interaction chromatography. Part I: Selection of chromatographic system and estimation of adsorption isotherms. Journal of Chromatography A: 1218 37, 6396-6401

Li,Z.; Kessler,Wolfgang; van den,Heuvel Joop*; Rinas,Ursula*; (2011). Simple defined autoinduction medium for high-level recombinant protein production using T7-based Escherichia coli expression systems. Applied Microbiology and Biotechnology: 91 4, 1203-1213 HZI-Repositorium PubMed

Wilke,S.; Gröbe,Lothar*; Maffenbeier,V.; Jäger,Volker*; Gossen,M.; Josewski,J.; Duda,A.; Polle,L.; Owens,R.J.; Wirth,Dagmar*; Heinz,Dirk* W.; van den,Heuvel Joop*; Büssow,Konrad*; (2011). Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development. PLoS ONE: 6 12, e27829

de Groot,J.C.; Schluter,K.; Carius,Y.; Quedenau,C.; Vingadassalom,D.; Faix,J.; Weiss,S.M.; Reichelt,J.; Standfuss-Gabisch,C.; Lesser,C.F.; Leong,J.M.; Heinz,Dirk W.*; Büssow,Konrad*; Stradal,Theresia E.*; (2011). Structural Basis for Complex Formation between Human IRSp53 and the Translocated Intimin Receptor Tir of Enterohemorrhagic E. coli. 19 9, 1294-1306

Lünsdorf,Heinrich*; Gurramkonda,C.; Adnan,A.; Khanna,N.; Rinas,Ursula*; (2011). Virus-like particle production with yeast: ultrastructural and immunocytochemical insights into Pichia pastoris producing high levels of the Hepatitis B surface antigen. Microbial Cell Factories: 10, 48 HZI-Repositorium PubMed

Gurramkonda,C.; Polez,S.; Skoko.N.; Adnan,A.; Gäbel,Th.; Chugh,D.; Swaminathan,S.; Khanna,N.; Tisminetzky,S.; Rinas,Ursula*; (2010). Application of simple fed-batch technique to high-level secretory production of insulin precursor using Pichia pastoris with subsequent purification and conversion to human insulin.. Microbial Cell Factories: 12 9, 31 HZI-Repositorium PubMed

Wilke,S.; Krausze,J.; Gossen,M.; Gröbe,Lothar*; Jager,V.; Gherardi,E.; van den,Heuvel J.; Bussow,Konrad*; (2010). Glycoprotein production for structure analysis with stable, glycosylation mutant CHO cell lines established by fluorescence-activated cell sorting. Protein Science: 19 6, 1264-1271

Martinez-Alonso,M.; Garcia-Fruitos,E.; Ferrer-Miralles,N.; Rinas,Ursula*; Villaverde,A.; (2010). Side effects of chaperone gene co-expression in recombinant protein production. Microbial Cell Factories: 9, 64 HZI-Repositorium PubMed

Lu,X.; Sun,J.; Nimtz,Manfred*; Wissing,J.; Zeng,A.-P.; Rinas,Ursula*; (2010). The intra- and extracellular proteome of Aspergillus niger growing on defined medium with xylose or maltose as carbon substrate. Microbial Cell Factories: 9 23, 1-13 HZI-Repositorium PubMed

Schliephake,H.; Zghoul,N.; Jäger,Volker*; van,Griensven M.; Zeichen,J.; Gelinsky,M.; Szubtarsky,N.; (2009). Bone formation in trabecular bone cell seeded scaffolds used for reconstruction of the rat mandible. International Journal of Oral and Maxillofacial Surgery Surgery: 38 2, 166-172

Shiloach,J.; Rinas,Ursula*; (2009). Glucose and acetate metbolism in E. coli - System level analysis and biotechnological applications in protein producing processes.: Systems Biology and Biotechnology of E. coli. Lee,S.-Y.; (Ed.). Berlin, Heidelberg, New York : Springer Netherlands, 377-400

Wiesand,U.; Sorg,I.; Amstutz,M.; Wagner,S.; van den Heuvel,Joop*; Lührs,Thorsten*; Cornelis,G.R.; Heinz,Dirk W.*; (2009). Structure of the type III secretion recognition protein YscU from Yersinia enterocolitica. Journal of Molecular Biology: 385 3, 854-866 HZI-Repositorium PubMed

Visser,R.; Arrabal,P.M.; Becerra,J.; Rinas,Ursula*; Cifuentes,M.; (2009). The effect of an rhBMP-2 absorbable collagen sponge-targeted system on bone formation in vivo. Biomaterials: 30 11, 2032-2037

Schliephake,H.; Zghoul,N.; Jäger,Volker*; van,Griensven M.; Zeichen,J.; Gelinsky,M.; Wulfing,T.; (2008). Effect of seeding technique and scaffold material on bone formation in tissue-engineered constructs. Journal of Biomedical Materials Research - A: 90 2, 429-437

Wollert,T.; Pasche,Bastian*; Rochon,Maike*; Deppenmeier,S.; van den Heuvel,Joop*; Gruber,A.D.; Heinz,Dirk W.*; Lengeling,Andreas*; Schubert,Wolf-Dieter*; (2007). Extending the host range of Listeria monocytogenes by rational protein design. Cell: 129 5, 891-902

Zieseniss,A.; Schroeder,U.; Buchmeier,S.; Schoenberger,C.; van den Heuvel,Joop*; Jockusch,B.; Illenberger,S.; (2007). Raver1 is an integral component of muscle contractile elements. Cell and Tissue Research: 327 3, 583-594 HZI-Repositorium PubMed

Niemann,H.N.; Jäger,Volker*; Butler,P.J.G.; van den Heuvel,Joop*; Schmidt,S.; Ferraris,D.; Gherardi,E.; Heinz,Dirk W.*; (2007). Structure of the human receptor tyrosine kinase met in complex with the Listeria monocytogenes Invasion Protein InlB. Cell: 130 2, 235-246 HZI-Repositorium PubMed

Zheng,P; Sun,Jibin*; van den Heuvel,Joop*; Zeng,An-Ping*; (2006). Discovery and investigation of a new, second triose phosphate isomerase in Klebsiella pneumoniae. Journal of Biotechnology: 125 4, 462-473

Zheng,P.; Wereath,K.; Sun,Jibin*; van den Heuvel,Joop*; Zeng,An-Ping*; (2006). Overexpression of genes of the dha regulon and its effects on cell growth, glycerol fermentation to 1,3-propanediol and plasmid stability in Klebsiella pneumoniae. Process Biochemistry: 41 10, 2160-2169

Dresler,K.; van den Heuvel,Joop*; Müller,Rolf-Joachim*; Deckwer,Wolf-Dieter*; (2006). Production of a recombinant polyester-cleaving hydrolase from Thermobifida fusca in Escherichia coli. Bioprocess and Biosystems Engineering: 29, 169-183

Kleeberg,I.; Welzel,K.; van den Heuvel,J.; Müller,R.-J.; Deckwer,W.-D.; (2005). Characterization of a new extracellular hydrolase from Thermobifida fusca degrading aliphatic-aromatic copolyesters. Biomacromolecules: 6, 262-270

Astner,I.; Schulze,J.O.; van den Heuvel,J.; Jahn,D.; Schubert,W.-D.; Heinz,D.W.; (2005). Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans. Embo Journal: 24, 3166-3177 HZI-Repositorium

Bollati-Fogolin,M.; Irani,N.; Beccaria,A.J.; Schulz,C.; van den Heuvel,J.; Elias,C.B.; Carpentier,E.; Durocher,Y.; Bisson,L.; Etcheverrigaray,M.; Kratje,R.B.; Wirth,M.; Kamen,A.; Wagner,R.; (2005). Impact of yeast pyruvate carboxylase on the productivity of animal host cell lines.: Animal Cell Technology Meets Genomics. Godia,F.; Fussenegger,M.; (Ed.). Dordrecht : Kluwer Academic Publishers, 87-89

Hoffmann,F.; van den Heuvel,J.; Zidek,N.; Rinas,U.; (2004). Minimizing inclusion body formation during recombiant protein production in Escherichia coli at bench and pilot plant scale.. Enzyme and Microbial Technology: 34, 235-241

Ross,A.; Kessler,W.; Krumme,D.; Menge,U.; Wissing,J.; van den Heuvel,J.; Flohé,L.; (2004). Optimised fermentation strategy for 13C/15N recombinant protein labelling in Escherichia coli for NMR-structure analysis. Journal of Biotechnology: 108, 31-39

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23.05.2012