Helmholtz-Zentrum für Infektionsforschung

Helmholtz-Zentrum für Infektionsforschung

Publikationen der Arbeitsgruppe

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Diaz,N.; Zhu,M.; Ehrlich,G.; Eggert,U.; Muthukumar,Y.; Sasse,Florenz*; Kalesse,Markus*; (2012). An improved route to (+)-tedanolide and analysis of its subtle effects controlling conformation and biological behaviour1. Chemistry: 18 16, 4946-4952

Eichner,S.; Eichner,T.; Floss,H.G.; Fohrer,J.; Hofer,E.; Sasse,Florenz*; Zeilinger,C.; Kirschning,A.; (2012). Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin1. Journal of the American Chemical Society: 134 3, 1673-1679

Taft,F.; Harmrolfs,K.; Nickeleit,I.; Heutling,A.; Kiene,M.; Malek,N.; Sasse,Florenz*; Kirschning,A.; (2012). Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3. Chemistry: 18 3, 880-886

Eichner,S.; Knobloch,T.; Floss,H.G.; Fohrer,J.; Harmrolfs,K.; Hermane,J.; Schulz,A.; Sasse,Florenz*; Spiteller,P.; Taft,F.; Kirschning,A.; (2012). The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library2. Angewandte Chemie International Edition: 51 3, 752-757

Reboll,M.R.; Ritter,B.; Sasse,Florenz*; Niggemann,Jutta*; Frank,Ronald*; Nourbakhsh,M.; (2012). The myxobacterial compounds spirangien a and spirangien m522 are potent inhibitors of IL-8 expression1. ChemBioChem: 13 3, 409-415

Montaner,A.D.; Denichilo,A.; Rodriguez,J.M.; Flo,J.; Lopez,R.A.; Pontoriero,A.; Savy,V.; Baumeister,E.; Frank,Ronald*; Zorzopulos,J.; Elias,F.; (2011). Addition of the immunostimulatory oligonucleotide IMT504 to a seasonal flu vaccine increases hemagglutinin antibody titers in young adult and elder rats, and expands the anti-hemagglutinin antibody repertoire. Nucleic Acid Therapeutics: 21 4, 265-274

Elsebai,M.F.; Kehraus,S.; Lindequist,U.; Sasse,Florenz*; Shaaban,S.; Gutschow,M.; Josten,M.; Sahl,H.G.; Konig,G.M.; (2011). Antimicrobial phenalenone derivatives from the marine-derived fungus Coniothyrium cereale. Organic and Biomolecular Chemistry: 9 3, 802-808

Horstmann,N.; Essig,S.; Bockelmann,S.; Wieczorek,H.; Huss,M.; Sasse,Florenz*; Menche,D.; (2011). Archazolid A-15-O-beta-d-glucopyranoside and iso-Archazolid B: Potent V-ATPase Inhibitory Polyketides from the Myxobacteria Cystobacter violaceus and Archangium gephyra. Journal of Natural Products: 74 5, 1100-1105 HZI-Repositorium PubMed

Grelle,G.; Otto,A.; Lorenz,M.; Frank,Ronald F.*; Wanker,E.E.; Bieschke,J.; (2011). Black Tea Theaflavins Inhibit Formation of Toxic Amyloid-beta and alpha-Synuclein Fibrils. Biochemistry: 50 49, 10624-10636

Effenberger-Neidnicht,K.; Breyer,S.; Mahal,K.; Diestel,R.; Sasse,Florenz*; Schobert,R.; (2011). Cellular localisation of antitumoral 6-alkyl thymoquinones revealed by an alkyne-azide click reaction and the streptavidin-biotin system. ChemBioChem: 12 8, 1237-1241 HZI-Repositorium PubMed

Biersack,B.; Muthukumar,Y.; Schobert,R.; Sasse,Florenz*; (2011). Cytotoxic and antivascular 1-methyl-4-(3-fluoro-4-methoxyphenyl)-5-(halophenyl)-imidazoles. Bioorganic and Medicinal Chemistry Letters: 21 21, 6270-6273

Manz,B.; Gotz,V.; Wunderlich,K.; Eisel,J.; Kirchmair,J.; Stech,J.; Stech,O.; Chase,G.; Frank,Ronald*; Schwemmle,M.; (2011). Disruption of the viral polymerase complex assembly as a novel approach to attenuate influenza A virus. Journal of Biological Chemistry: 286 10, 8414-8424

Elsebai,M.F.; Natesan,L.; Kehraus,S.; Mohamed,I.E.; Schnakenburg,G.; Sasse,Florenz*; Shaaban,S.; Gutschow,M.; Konig,G.M.; (2011). HLE-Inhibitory Alkaloids with a Polyketide Skeleton from the Marine-Derived Fungus Coniothyrium cereale. Journal of Natural Products: 74 10, 2282-2285

Wunderlich,K.; Juozapaitis,M.; Ranadheera,C.; Kessler,U.; Martin,A.; Eisel,J.; Beutling,U.; Frank,Ronald*; Schwemmle,M.; (2011). Identification of High-Affinity PB1-Derived Peptides with Enhanced Affinity to the PA Protein of Influenza A Virus Polymerase. Antimicrobial Agents and Chemotherapy: 55 2, 696-702

Knappe,T.A.; Manzenrieder,F.; Mas-Moruno,C.; Linne,U.; Sasse,Florenz*; Kessler,H.; Xie,X.; Marahiel,M.A.; (2011). Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist. Angewandte Chemie International Edition: 50 37, 8714-8717

Omnus,D.J.; Mehrtens,S.; Ritter,B.; Resch,K.; Yamada,M.; Frank,Ronald*; Nourbakhsh,M.; Reboll,M.R.; (2011). JKTBP1 Is Involved in Stabilization and IRES-Dependent Translation of NRF mRNAs by Binding to 5' and 3' Untranslated Regions. Journal of Molecular Biology: 407 4, 492-504 HZI-Repositorium PubMed

Reboll,M.R.; Schweda,A.T.; Bartels,M.; Franke,R.; Frank,Ronald*; Nourbakhsh,M.; (2011). Mapping of NRF binding motifs of NF-kappaB p65 subunit. Journal of Biochemistry: 150 5, 553-562

Kraemer,S.; Lue,H.; Zernecke,A.; Kapurniotu,A.; Andreetto,E.; Frank,Ronald*; Lennartz,B.; Weber,C.; Bernhagen,J.; (2011). MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism. FASEB journal: 25 3, 894-906

Effenberger-Neidnicht,K.; Breyer,S.; Mahal,K.; Sasse,Florenz*; Schobert,R.; (2011). Modification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence. Cancer Chemotherapy and Pharmacology: 69 1, 85-90 HZI-Repositorium PubMed

Knobloch,T.; Harmrolfs,K.; Taft,F.; Thomaszewski,B.; Sasse,Florian*; Kirschning,A.; (2011). Mutational Biosynthesis of Ansamitocin Antibiotics: A Diversity-oriented Approach to Exploit Biosynthetic Flexibility. ChemBioChem: 13 4, 540-547 HZI-Repositorium PubMed

Buntru,A.; Kopp,K.; Voges,M.; Frank,Ronald*; Bachmann,V.; Hauck,C.R.; (2011). Phosphatidylinositol 3'-kinase activity is critical for initiating the oxidative burst and bacterial destruction during CEACAM3-mediated phagocytosis. Journal of Biological Chemistry: 286 11, 9555-9566

Capell,A.; Liebscher,S.; Fellerer,K.; Brouwers,N.; Willem,M.; Lammich,S.; Gijselinck,I.; Bittner,T.; Carlson,A.M.; Sasse,Florenz*; Kunze,B.; Steinmetz,H.; Jansen,Rolf*; Dormann,D.; Sleegers,K.; Cruts,M.; Herms,J.; Van,Broeckhoven C.; Haass,C.; (2011). Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase. Journal of Neuroscience: 31 5, 1885-1894

Bieschke,J.; Herbst,M.; Wiglenda,T.; Friedrich,R.P.; Boeddrich,A.; Schiele,F.; Kleckers,D.; Lopez Del Amo,J.M.; Gruning,B.A.; Wang,Q.; Schmidt,M.R.; Lurz,R.; Anwyl,R.; Schnoegl,S.; Fandrich,M.; Frank,Ronald F.*; Reif,B.; Gunther,S.; Walsh,D.M.; Wanker,E.E.; (2011). Small-molecule conversion of toxic oligomers to nontoxic beta-sheet-rich amyloid fibrils. Nature Chemical Biology: 8 1, 93-101

Anderl,T.; Nicolas,L.; Münkemer,J.; Muthukumar,Y.; Baro,A.; Frey,W.; Sasse,Florenz*; Taylor,R.E.; Laschat,S.; (2011). Synthesis and biological evaluation of gephyronic acid derivatives: Initial steps towards the identification of the biological target of polyketide inhibitors of eukaryotic protein synthesis. European Journal of Organic Chemistry: 36, 7294-7307

Müller,S.; Mayer,T.; Sasse,Florenz*; Maier,M.E.; (2011). Synthesis of a Pladienolide B Analogue with the Fully Functionalized Core Structure. Organic Letters: 13 15, 3940-3943

Zhdanko,A.; Schmauder,A.; Ma,C.I.; Sibley,L.D.; Sept,D.; Sasse,Florenz*; Maier,M.E.; (2011). Synthesis of Chondramide A Analogues with Modified beta-Tyrosine and Their Biological Evaluation. Chemistry: 17 47, 13349-13357

Garcia,J.; Barluenga,S.; Gorska,K.; Sasse,Florenz*; Winssinger,N.; (2011). Synthesis of deguelin-biotin conjugates and investigation into deguelin's interactions3573. Bioorganic and Medicinal Chemistry: 20 2, 672-680

Fries,T.; Frank,Ronald*; Bailer,S.M.; (2011). The Saccharomyces cerevisiae ubiquitin E3 ligase Asr1p targets calmodulin for ubiquitylation. Biochemical and Biophysical Research Communications: 411 1, 197-201

Ushakov,D.B.; Navickas,V.; Strobele,M.; Maichle-Mossmer,C.; Sasse,Florenz*; Maier,M.E.; (2011). Total synthesis and biological evaluation of (-)-9-deoxy-englerin A. Organic Letters: 13 8, 2090-2093

Nickl,C.K.; Raidas,S.K.; Zhao,H.; Sausbier,M.; Ruth,P.; Tegge,Werner*; Brayden,J.E.; Dostmann,W.R.; (2010). (d)-Amino acid analogues of DT-2 as highly selective and superior inhibitors of cGMP-dependent protein kinase Ialpha. Biochimica et biophysica acta: 1804 3, 524-532

Gloriam,D.E.; Orchard,S.; Bertinetti,D.; Bjorling,E.; Bongcam-Rudloff,E.; Borrebaeck,C.A.; Bourbeillon,J.; Bradbury,A.R.; de,Daruvar A.; Dubel,S.; Frank,Roland*; Gibson,T.J.; Gold,L.; Haslam,N.; Herberg,F.W.; Hiltke,T.; Hoheisel,J.D.; Kerrien,S.; Koegl,M.; Konthur,Z.; Korn,B.; Landegren,U.; Montecchi-Palazzi,L.; Palcy,S.; Rodriguez,H.; Schweinsberg,S.; Sievert,V.; Stoevesandt,O.; Taussig,M.J.; Ueffing,M.; Uhlen,M.; van der,Maarel S.; Wingren,C.; Woollard,P.; Sherman,D.J.; Hermjakob,H.; (2010). A community standard format for the representation of protein affinity reagents. Molecular and Cellular Proteomics: 9 1, 1-10

Schlenk,A.; Diestel,R.; Sasse,Florenz*; Schobert,R.; (2010). A selective 3-acylation of tetramic acids and the first synthesis of ravenic acid. Chemistry: 16 8, 2599-2604 HZI-Repositorium PubMed

Westermann,J.; Florcken,A.; Willimsky,G.; van,Lessen A.; Kopp,J.; Takvorian,A.; Johrens,K.; Lukowsky,A.; Schonemann,C.; Sawitzki,B.; Pohla,H.; Frank,Ronald*; Dorken,B.; Schendel,D.J.; Blankenstein,T.; Pezzutto,A.; (2010). Allogeneic gene-modified tumor cells (RCC-26/IL-7/CD80) as a vaccine in patients with metastatic renal cell cancer: a clinical phase-I study. Gene Therapy: 18 4, 354-363 HZI-Repositorium PubMed

Micklinghoff,J.C.; Schmidt,M.; Geffers,Robert*; Tegge,Werner*; Bange,F.C.; (2010). Analysis of expression and regulatory functions of the ribosome-binding protein TypA in Mycobacterium tuberculosis under stress conditions. Archives of Microbiology: 192 6, 499-504

Schulz,S.; Dickschat,J.S.; Kunze,B.; Wagner-Döbler,Irene*; Diestel,R.; Sasse,Florenz*; (2010). Biological activity of volatiles from marine and terrestrial bacteria. Marine Drugs: 8, 2976-2987

Meens,J.; Bolotin,V.; Frank,Ronald*; Bohmer,J.; Gerlach,G.F.; (2010). Characterization of a highly immunogenic Mycoplasma hyopneumoniae lipoprotein Mhp366 identified by peptide-spot array. Veterinary Microbiology: 142 3-4, 293-302

Harmrolfs,K.; Brunjes,M.; Drager,G.; Floss,H.G.; Sasse,Florenz*; Taft,F.; Kirschning,A.; (2010). Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst. ChemBioChem: 11 18, 2517-2520

Ritter,B.; Kilian,P.; Reboll,M.R.; Resch,K.; Distefano,J.K.; Frank,Ronald*; Beil,W.; Nourbakhsh,M.; (2010). Differential Effects of Multiplicity of Infection on Helicobacter pylori-Induced Signaling Pathways and Interleukin-8 Gene Transcription. Journal of Clinical Immunology: 31 1, 60-68

Maenz,B.; Goetz,V.; Wunderlich,K.; Eisel,J.; Kirchmair,J.; Stech,J.; Stech,O.; Chase,G.; Frank,Ronald*; Schwemmle,M.; (2010). Disruption of the viral polymerase complex assembly as a novel approach to attenuate influenza a virus. Journal of Biological Chemistry: 286 10, 8414-8424

Beutling,U.; Frank,Ronald*; (2010). Epitope analysis using synthetic peptide repertoires prepared by SPOT synthesis technology.: Antibody Engineering. Kontermann,R.; Dübel,S.; (Ed.). Berlin, Heidelberg : Springer-Verlag

Frank,Ronald*; Theis,F.J.; Klamt,S.; (2010). From binary to multivalued to continuous models: the lac operon as a case study. Journal of Integrative Bioinformatics: 7 1, 151-169 HZI-Repositorium PubMed

Franke,R.; Theis,F.J.; Klamt,S.; (2010). From binary to multivalued to continuous models: the lac operon as a case study.. Journal of Integrative Bioinformatics: HZI-Repositorium PubMed

Voigt,J.; Kiess,M.; Getzlaff,R.; Wostemeyer,J.; Frank,Ronald*; (2010). Generation of the heterodimeric precursor GP3 of the Chlamydomonas cell wall. Molecular Microbiology: 77 6, 1512-1526

Nicolas,L.; Anderl,T.; Sasse,Florenz*; Steinmetz,H.; Jansen,Rolf*; Hofle,G.; Laschat,S.; Taylor,R.E.; (2010). Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part I): Structural Revision and Stereochemical Assignment of Gephyronic Acid. Angewandte Chemie International Edition: 50 4, 938-941

Anderl,T.; Nicolas,L.; Munkemer,J.; Baro,A.; Sasse,Florenz*; Steinmetz,H.; Jansen,Rolf*; Hofle,G.; Taylor,R.E.; Laschat,S.; (2010). Gephyronic Acid, a Missing Link between Polyketide Inhibitors of Eukaryotic Protein Synthesis (Part II): Total Synthesis of Gephyronic Acid. Angewandte Chemie International Edition: 50 4, 942-945

Schneider,J.; Fricke,Christin*; Overwin,H.; Hofer,Bernd*; (2010). High level expression of a recombinant amylosucrase gene and selected properties of the enzyme. Applied Microbiology and Biotechnology: 89 6, 1821-1829 HZI-Repositorium PubMed

Andreetto,E.; Yan,L.M.; Tatarek-Nossol,M.; Velkova,A.; Frank,Ronald*; Kapurniotu,A.; (2010). Identification of Hot Regions of the Abeta-IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association. Angewandte Chemie - International Edition: 49 17, 3081-3085

Brodmann,T.; Janssen,D.; Sasse,Florenz*; Irschik,Herbert*; Jansen,Rolf*; Müller,Rolf*; Kalesse,Markus*; (2010). Isolation and synthesis of chivotriene, a chivosazole shunt product from Sorangium cellulosum. European Journal of Organic Chemistry: 27, 5155-5159

Meyer,T.; Stratmann-Selke,J.; Meens,J.; Schirrmann,T.; Gerlach,G.F.; Frank,Ronald*; Dubel,S.; Strutzberg-Minder,K.; Hust,M.; (2010). Isolation of scFv fragments specific to OmpD of Salmonella Typhimurium. Veterinary Microbiology: 147 1-2, 162-169

Heinzelmann,K.; Scholz,B.A.; Nowak,A.; Fossum,E.; Kremmer,E.; Haas,J.; Frank,Ronald*; Kempkes,B.; (2010). Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 (vIRF4/K10) is a novel interaction partner of CSL/CBF1, the major downstream effector of Notch signaling. Journal of Virology: 84 23, 12255-12264 HZI-Repositorium PubMed

Bourbeillon,J.; Orchard,S.; Benhar,I.; Borrebaeck,C.; de,Daruvar A.; Dubel,S.; Frank,Ronald*; Gibson,F.; Gloriam,D.; Haslam,N.; Hiltker,T.; Humphrey-Smith,I.; Hust,M.; Juncker,D.; Koegl,M.; Konthur,Z.; Korn,B.; Krobitsch,S.; Muyldermans,S.; Nygren,P.A.; Palcy,S.; Polic,B.; Rodriguez,H.; Sawyer,A.; Schlapshy,M.; Snyder,M.; Stoevesandt,O.; Taussig,M.J.; Templin,M.; Uhlen,M.; van der,Maarel S.; Wingren,C.; Hermjakob,H.; Sherman,D.; (2010). Minimum information about a protein affinity reagent (MIAPAR). Nature Biotechnology: 28 7, 650-653 HZI-Repositorium PubMed

Bremer,C.M.; Sominskaya,I.; Skrastina,D.; Pumpens,P.; Wahed,A.A.; Beutling,U.; Frank,Ronald*; Fritz,H.J.; Hunsmann,G.; Gerlich,W.H.; Glebe,D.; (2010). N-terminal myristoylation-dependent masking of neutralizing epitopes in the preS1 attachment site of hepatitis B virus. Journal of Hepatology: 11 1, 29-37

Sharma,R.K.; Sundriyal,S.; Wangoo,N.; Tegge,Werner*; Jain,R.; (2010). New antimicrobial hexapeptides: synthesis, antimicrobial activities, cytotoxicity, and mechanistic studies. ChemMedChem: 5 1, 86-95

Buchner,A.; Pohla,H.; Willimsky,G.; Frankenberger,B.; Frank,Ronald*; Baur-Melnyk,A.; Siebels,M.; Stief,C.G.; Hofstetter,A.; Kopp,J.; Pezzutto,A.; Blankenstein,T.; Oberneder,R.; Schendel,D.J.; (2010). Phase 1 trial of allogeneic gene-modified tumor cell vaccine RCC-26/CD80/IL-2 in patients with metastatic renal cell carcinoma. Human gene therapy: 21 3, 285-297

Rink,C.; Sasse,Florenz*; Zubriene,A.; Matulis,D.; Maier,M.E.; (2010). Probing the influence of an allylic methyl group in zearalenone analogues on binding to Hsp90. Chemistry: 16 48, 14469-14478

Barnickel,B.; Bayliffe,F.; Diestel,R.; Kempf,K.; Laschat,S.; Pachali,S.; Sasse,Florenz*; Schlenk,A.; Schobert,R.; (2010). Structure-activity relationships of precursors and analogs of natural 3-enoyl-tetramic acids. Chemistry & Biodiversity: 7 12, 2830-2845 HZI-Repositorium PubMed

Bulow,L.; Nickeleit,I.; Girbig,A.K.; Brodmann,T.; Rentsch,A.; Eggert,U.; Sasse,Florenz*; Steinmetz,Heinrich*; Frank,Ronald*; Carlomagno,T.; Malek,N.P.; Kalesse,Markus*; (2010). Synthesis and biological characterization of argyrin F. ChemMedChem: 5 6, 832-836

Schackel,R.; Hinkelmann,B.; Sasse,Florenz*; Kalesse,Markus*; (2010). The synthesis of novel disorazoles. Angewandte Chemie International Edition: 49 9, 1619-1622

Kubicek,K.; Grimm,S.K.; Orts,J.; Sasse,Florenz*; Carlomagno,T.; (2010). The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin. Angewandte Chemie International Edition: 49 28, 4809-4812

Schobert,R.; Sasse,Florenz*; Biersack,B.; Effenberger,K.; Breyer,S.; Diestel,R.; (2010). Tumor-selective amphiphilic para-quinones and tetramic acids. International Journal of Clinicl Pharmacology and Therapeutics: 48 7, 459-461 HZI-Repositorium PubMed

Meens,J.; Bolotin,V.; Frank,Ronald*; Bohmer,J.; Gerlach,G.F.; (2009). Characterization of a highly immunogenic Mycoplasma hyopneumoniae lipoprotein Mhp366 identified by peptide-spot array. Veterinary Microbiology: 142 3-4, 293-302

Diestel,R.; Irschik,Herbert*; Jansen,Rolf*; Khalil,M.W.; Reichenbach,H.; Sasse,Florian*; (2009). Chivosazoles A and F, cytostatic macrolides from myxobacteria, interfere with actin. ChemBioChem: 10 18, 2900-2903 HZI-Repositorium PubMed

Lisurek,M.; Rupp,B.; Wichard,J.; Neuenschwander,M.; von Kries,J.P.; Frank,Ronald*; Rademann,J.; Kuhne,R.; (2009). Design of chemical libraries with potentially bioactive molecules applying a maximum common substructure concept. Molecular Diversity: 14 2, 401-408

Sharma,R.K.; Reddy,R.P.; Tegge,Werner*; Jain,R.; (2009). Discovery of Trp-His and His-Arg analogues as new structural classes of short antimicrobial peptides. Journal of Medicinal Chemistry: 52 23, 7421-7431

Lottersberger,J.; Guerrero,S.A.; Tonarelli,G.G.; Frank,Ronald*; Tarabla,H.; Vanasco,N.B.; (2009). Epitope mapping of pathogenic Leptospira LipL32. Letters in Applied Microbiology: 49 5, 641-645 HZI-Repositorium PubMed

Galeyeva,Y.; Morr,M.; Sasse,Florian*; Diestel,R.; Laschat,S.; Baro,A.; Frey,W.; (2009). Ex chiral pool synthesis from a highly methyl-branched wax ester and biological properties of (+)-capensifuranone. Zeitschrift für Naturforschung B - A Journal of Chemical Sciences: 64 6, 639-645

Mecklenburg,S.; Shaaban,S.; Ba,L.A.; Burkholz,T.; Schneider,T.; Diesel,B.; Kiemer,A.K.; Roseler,A.; Becker,K.; Reichrath,J.; Stark,A.; Tilgen,W.; Abbas,M.; Wessjohann,L.A.; Sasse,Florenz*; Jacob,C.; (2009). Exploring synthetic avenues for the effective synthesis of selenium- and tellurium-containing multifunctional redox agents. Organic and Biomolecular Chemistry: 7 22, 4753-4762

Suryanarayanan,T.S.; Thirunavukkarasu,N.; Gowindarajulu,M.B.; Sasse,Florian*; Jansen,Rolf*; Murali,T.S.; (2009). Fungal endophytes and bioprospecting. Fungal Biology Reviews: 23 1-2, 9-19 HZI-Repositorium

Schneider,J.; Fricke,C.; Overwin,H.; Hofmann,B.; Hofer,Bernd*; (2009). Generation of amylosucrase variants that terminate catalysis of acceptor elongation at the di- or trisaccharide stage. Applied and Environmental Microbiology: 75 23, 7453-7460

Turner,J.G.; Marchion,D.C.; Dawson,J.L.; Emmons,M.F.; Hazlehurst,L.A.; Washausen,Peter*; Sullivan,D.M.; (2009). Human multiple myeloma cells are sensitized to topoisomerase II inhibitors by CRM1 inhibition. Cancer Research: 69 17, 6899-6905

Wunderlich,K.; Mayer,D.; Ranadheera,C.; Holler,A.S.; Manz,B.; Martin,A.; Chase,G.; Tegge,Werner*; Frank,Ronald*; Kessler,U.; Schwemmle,M.; (2009). Identification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication. PLoS ONE: 4 10, e7517 HZI-Repositorium PubMed

Schutte,M.; Thullier,P.; Pelat,T.; Wezler,X.; Rosenstock,P.; Hinz,D.; Kirsch,M.I.; Hasenberg,M.; Frank,Ronald*; Schirrmann,T.; Gunzer,M.; Hust,M.; Dubel,S.; (2009). Identification of a putative Crf splice variant and generation of recombinant antibodies for the specific detection of Aspergillus fumigatus. PLoS ONE: 4 8, e6625

Weiss,S.M.; Ladwein,M.; Schmidt,D.; Ehinger,J.; Lommel,S.; Städing,K.; Beutling,U.; Disanza,A.; Frank,Ronald*; Jänsch,Lothar*; Scita,G.; Gunzer,F.; Rottner,Klemens*; Stradal,Theresia E.*; (2009). IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation. Cell Host and Microbe: 5 3, 244-258

Poltz,R.; Franke,Raimo*; Schweitzer,K.; Klamt,S.; Gilles,E.-D.; Naumann,M.; G; (2009). Logical network of genotoxic stress-induced NF-kappaB signal transduction predicts putative target structures for therapeutic intervention strategies. Advances and Applications in Bioinformatics and Chemistry: 2009 2, 125-138

Biersack,B.; Diestel,R.; Jagusch,C.; Sasse,Florenz*; Schobert,R.; (2009). Metal complexes of natural melophlins and their cytotoxic and antibiotic activities. Journal of Inorganic Biochemistry: 103 1, 72-76 HZI-Repositorium PubMed

Lucas,N.; Franke,R.; Hinze,A.; Klages,C.-P.; Frank,Ronald*; Büttgenbach,S.; (2009). Microplasma stamps for area-selective modification of polymer surfaces. Plasma Processes and Polymers: 6, 5370-5374 HZI-Repositorium

Shabaan,S.; Ba,L.A.; Abbas,M.; Burkholz,T.; Denkert,A.; Gohr,A.; Wessjohann,L.A.; Sasse,Florenz*; Weber,W.; Jacob,C.; (2009). Multicomponent reactions for the synthesis of multifunctional agents with activity against cancer cells. 31, 4702-4704

Bocquet,A.; Berges,R.; Frank,Ronald*; Robert,P.; Peterson,A.C.; Eyer,J.; (2009). Neurofilaments bind tubulin and modulate its polymerization. Journal of Neuroscience: 29 35, 11043-11054

Eichner,S.; Floss,H.G.; Sasse,Florenz*; Kirschning,A.; (2009). New, highly active nonbenzoquinone geldanamycin derivatives by using mutasynthesis. ChemBioChem: 10 11, 1801-1805

Ugele,M.; Sasse,Florian*; Knapp,S.; Fedorov,O.; Zubriene,A.; Matulis,D.; Maier,M.E.; (2009). Propionate analogues of zearalenone bind to Hsp90. ChemBioChem: 10 13, 2203-2212

Kratzer,U.; Frank,Ronald*; Kalbacher,H.; Biehl,B.; Wostemeyer,J.; Voigt,J.; (2009). Subunit structure of the vicilin-like globular storage protein of cocoa seeds and the origin of cocoa- and chocolate-specific aroma precursors. Food Chemistry: 113 4, 903-913

Voigt,J.; Frank,Ronald*; Wostemeyer,J.; (2009). The chaotrope-soluble glycoprotein GP1 is a constituent of the insoluble glycoprotein framework of the Chlamydomonas cell wall. Fems Microbiology Letters: 291 2, 209-215

Ottinger,M.; Pliquet,D.; Christalla,T.; Frank,Ronald*; Stewart,J.P.; Schulz,T.F.; (2009). The interaction of the gammaherpesvirus 68 orf73 protein with cellular BET proteins affects the activation of cell cycle promoters. Journal of Virology: 83 9, 4423-4434 HZI-Repositorium PubMed

Nickeleit,I.; Zender,S.; Sasse,Florenz*; Geffers,Robert*; Brandes,G.; Sorensen,I.; Steinmetz,Heinrich*; Kubicka,S.; Carlomagno,T.; Menche,D.; Gutgemann,I.; Buer,J.; Gossler,A.; Manns,M.P.; Kalesse,Markus*; Frank,Ronald*; Malek,N.P.; (2008). Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. 14 1, 23-35

Eggert,U.; Diestel,R.; Sasse,Florenz*; Jansen,Rolf*; Kunze,Brigitte*; Kalesse,Markus*; (2008). Chondramide C: Synthesis, configurational assignment, and structure-activity relationship studies. Angewandte Chemie - International Edition: 47 43, 6478-6482

Hellmuth,H.; Wittrock,S.; Kralj,S.; Dijkhuizen,L.; Hofer,Bernd*; Seibel,J.; (2008). Engineering the Glucansucrase GTFR Enzyme Reaction and Glycosidic Bond Specificity: Toward Tailor-Made Polymer and Oligosaccharide Products. Biochemistry: 47 25, 6678-6684

Biersack,B.; Diestel,R.; Jagusch,C.; Rapp,G.; Sasse,Florian*; Schobert,R.; (2008). First syntheses of melophlins P, Q, and R, and effects of melophlins on the growth of microorganisms and tumor cells. Chemistry & Biodiversity: 5 11, 2423-2430 Volltext HZI-Repositorium PubMed

Swistowska,A.M.; Wittrock,S.; Collisi,Wera*; Hofer,Bernd*; (2008). Heterologous hyper-expression of a glucansucrase-type glycosyltransferase gene. Applied Microbiology and Biotechnology: 79 2, 255-261

Taft,F.; Brunjes,M.; Floss,H.G.; Czempinski,N.; Grond,S.; Sasse,Florian*; Kirschning,A.; (2008). Highly active ansamitocin derivatives: mutasynthesis using an AHBA-blocked mutant. ChemBioChem: 9 7, 1057-1060

Jansen,Rolf*; Steinmetz,Heinrich*; Sasse,Florenz*; Schubert,Wolf-Dieter*; Hagelüken,Gregor*; Albrecht,S.C.; Müller,Rolf*; (2008). Isolation and structure revision of the actin-binding macrolide rhizopodin from Myxococcus stipitatus (Myxobacteria). Tetrahedron Letters: 49, 5796-5799

Beutling,U.; Stading,K.; Stradal,Theresia E.B.*; Frank,Ronald*; (2008). Large-scale analysis of protein-protein interactions using cellulose-bound peptide arrays. Advances in Biochemical Engineering/Biotechnology: 110, 115-152 HZI-Repositorium PubMed

Wittrock,S.; Swistowska,A.M.; Collisi,Wera*; Hofmann,B.; Hecht,Hans-Jürgen*; Hofer,Bernd*; (2008). Re- or displacement of invariant residues in the C-terminal half of the catalytic domain strongly affects catalysis by glucosyltransferase R. Febs Letters: 582 4, 491-496

Höfle,Gerhard*; Bohlendorf,B.; Fecker,T.; Sasse,Florian*; Kunze,Brigitte*; (2008). Semisynthesis and Antiplasmodial Activity of the Quinoline Alkaloid Aurachin E. Journal of Natural Products: 71 11, 1967-1969

Vintonyak,V.V.; Cala,M.; Lay,F.; Kunze,Brigitte*; Sasse,Florian*; Maier,M.E.; (2008). Synthesis and biological evaluation of cruentaren A analogues. Chemistry - A European Journal: 14 12, 3709-3720

Cramer,N.; Helbig,S.; Baro,A.; Laschat,S.; Diestel,R.; Sasse,Florenz*; Mathieu,D.; Richter,C.; Kummerlowe,G.; Luy,B.; Schwalbe,H.; (2008). Synthesis and biological properties of cylindramide derivatives: evidence for calcium-dependent cytotoxicity of tetramic acid lactams. ChemBioChem: 9 15, 2474-2486 Volltext HZI-Repositorium

Timm,C.; Volk,C.; Sasse,Florian*; Kock,M.; (2008). The first cyclic monomeric 3-alkylpyridinium alkaloid from natural sources: identification, synthesis, and biological activity. Organic & Biomolecular Chemistry: 6 21, 4036-4040

Kolberg,J.; Hammerschmidt,S.; Frank,Ronald*; Jonak,J.; Sanderova,H.; Aase,A.; (2008). The surface-associated elongation factor Tu is concealed for antibody binding on viable pneumococci and meningococci. Fems Immunology and Medical Microbiology: 53 2, 222-230 HZI-Repositorium PubMed

Vintonyak,V.V.; Kunze,Brigitte*; Sasse,Florian*; Maier,M.E.; (2008). Total synthesis and biological activity of neopeltolide and analogues. Chemistry: 14 35, 11132-11140

Ebensen,T.; Link,C.; Riese,P.; Schulze,K.; Morr,M.; Guzmán,Carlos A.*; (2007). A pegylated derivative of alpha-galactosylceramide exhibits improved biological properties. 179 4, 2065-2073

Menche,Dirk*; Hassfeld,J.; Steinmetz,Heinrich*; Huss,M.; Wieczorek,H.; Sasse,Florian*; (2007). Archazolid-7-O//b//-d-glucopyranosid: Isolation, structural elucidation and solution conformation of a novel V-ATPase inhibitor from the Myxobacterium / Cystobacter violaceus. European Journal of Organic Chemistry: 2007, 1196-1202 HZI-Repositorium

Chase,G.; Mayer,D.; Hildebrand,A.; Frank,Ronald*; Hayashi,Y.; Tomonaga,K.; Schwemmle,M.; (2007). Borna disease virus matrix protein is an integral component of the viral rionucleoprotein complex that does not interfere with polymerase activity. Journal of Virology: 81 2, 743-749 Volltext HZI-Repositorium

Meyer,A.; Brünjes,M.; Taft,F.; Frenzel,T.; Sasse,Florian*; Kirschning,A.; (2007). Chemoenzymatic approaches toward dechloroansamitocin P-3. Organic Letters: 9 8, 1489-1492

Kunze,Brigitte*; Sasse,Florian*; Wieczorek,H.; Huss,M.; (2007). Cruentaren A, a highly cytotoxic benzolactone from Myxobacteria is a novel selective inhibitor of mitochondrial F1-ATPases. Febs Letters: 581 18, 3523-3527

Menche,Dirk*; Hassfeld,J.; Sasse,Florian*; Huss,M.; Wieczorek,H.; (2007). Design, synthesis and biological evaluation of novel analogues of archazolid: a highly potent simplified V-ATPase inhibitor. Bioorganic & Medicinal Chemistry Letters: 17 6, 1732-1735

Patterson,A.W.; Peltier,H.M.; Sasse,Florian*; Ellman,J.A.; (2007). Design, synthesis, and biological properties of highly potent tubulysin D analogues. Chemisty - A European Journal: 13, 9534-9541

Schirrmann,T.; Hust,M.; Konthur,Z.; Frank,Ronald*; Toleikis,L.; Dübel,S.; (2007). Die Antibody Factory - Schlüsselreagenzien für die Proteomforschung im Hochdurchsatz. Laborwelt: 8 2, 16-20

Menche,Dirk*; Arikan,F.; Li,J.; Rudolph,S.; Sasse,Florian*; (2007). Efficient one-pot synthesis of biologically active polysubstituted aromatic amines. Bioorganic & Medicinal Chemistry: 15 23, 7311-7317

Elnakady,Y.A.; Rohde,Manfred*; Sasse,Florian*; Backes,C.; Keller,A.; Lenhof,H.-P.; Weissman,K.J.; Müller,Rolf*; (2007). Evidence for the mode of the highly cytotoxic Streptomyces polyketide Kendomycin. ChemBioChem: 8 11, 1261-1272

Camara,B.; Seeger,M.; Gonzalez,M.; Standfuß-Gabisch,C.; Kahl,S.; Hofer,Bernd*; (2007). Generation by a widely applicable approach of a hybrid dioxygenase showing improved oxidation of polychlorobiphenyls. Applied and Environmental Microbiology: 73 8, 2682-2689 HZI-Repositorium PubMed

Rübenhagen,R.; Frank,Ronald*; (2007). Highly specific antibodies for use in sandwich-type antibody microarray analyses of complex biological samples.: Peptides 2006. Proc. 29 Europ. Peptide. Rolka,K.; Rekowski,P.; Silberring,J.; (Ed.). Geneva : Kenes International, 300-301

Selke,M.; Meens,J.; Springer,S.; Frank,Ronald*; Gerlach,G.-F.; (2007). Immunization of pigs to prevent disease in humans: Construction and protective efficacy of a Salmonella enterica serovar typhimurium live negative-marker vaccine. Infection and Immunity: 75 5, 2476-2483 HZI-Repositorium PubMed

Grube,A.; Assmann,M.; Lichte,E.; Sasse,Florian*; Pawlik,J.R.; Köck,A.; (2007). New bioactive metabolites from the Caribbean sponge Aka coralliphagum. Journal of Natural Products: 70 4, 504-509

Bartels,M.; Schweda,A.T.; Dreikhausen,U.; Frank,Ronald*; Resch,K.; Beil,W.; Nourbakhsh,M.; (2007). Peptide mediated disruption of NF-kappaB/NRF interaction inhibits IL-8 gene activation by IL-1 or Helicobacter pylori. Journal of Immunology: 179 11, 7605-7613 Volltext HZI-Repositorium

Ghanem,A.; Mayer,D.; Chase,G.; Tegge,Werner*; Frank,Ronald*; Kochs,G.; Garcia-Sastre,A.; Schwemmle,M.; (2007). Peptide-mediated interference with the influenza A virus polymerase. Journal of Virology: 81 14, 7801-7804 HZI-Repositorium PubMed

Krohn,K.; Gehle,D.; Dey,S.K.; Nahar,N.; Mosihuzzaman,M.; Sultana,N.; Sohroab,M.H.; Stephens,P.J.; Pan,J.-J.; Sasse,Florian*; (2007). Prismatomerin, a new irioid from Prismatomeris tetrandra . Structure elucidation, determination of absolute configuration, and cytotoxicity. Journal of Natural Products: 70 8, 1339-1343 HZI-Repositorium PubMed

Umbach,P.; Lange,U.; Frank,Ronald*; Schnögl,S.; Wanker,E.; (2007). Proteinnetzwerke als Grundlage für neue Therapieansätze. GenomXPress (Sonderausgabe): 2/07, 45-47

Taussig,M.J.; Stoevesandt,O.; Borrebaeck,C.A.K.; Bradbury,A.R.; Cahill,D.; Cambillau,C.; De Daruvar,A.; Dübel,S.; Eichler,Jutta*; Frank,Ronald*; Gibson,T.J.; Gloriam,D.; Gold,T.; Herberg,F.W.; Hermjakob,H.; Hoheisel,J.D.; Joos,T.O.; Kallioniemi,O.; Koegll,M.; Konthur,Z.; Korn,B.; Kremmer,E.; Krobitsch,S.; Landegren,U.; van der Maarel,S.; McCafferty,J.; Muyldermans,S.; Nygren,P.A.; Palcy,S.; Plückthun,A.; Polic,B.; Przybylski,M.; Saviranta,P.; Sawyer,A.; Sherman,D.J.; Skerra,A.; Templin,M.; Ueffing,M.; Uhlén,M.; (2007). ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nature Methods: 4, 13-17

Frank,Ronald*; (2007). Segmented solid supports: My personal addiction to Merrifield's solid phase synthesis. International Journal of Peptide Research and Therapeutics: 13 1-2, 45-52 HZI-Repositorium

Sasse,Florian*; Menche,Dirk*; (2007). Success in tubulysin D synthesis. Nature Chemical Biology: 3 2, 87-89

Ritschel,J.; Sasse,Florian*; Maier,M.E.; (2007). Synthesis of a benzolactone collection using click chemistry. European Journal of Organic Chemistry: 2007, 78-87 HZI-Repositorium

Tegge,Werner*; Bautsch,W.; Frank,Ronald*; (2007). Synthesis of cyclic peptides and peptide libraries on a new disulfide linker. Journal of Peptide Science: 13 10, 693-699

Soutullo,A.; Santi,M.N.; Perin,J.C.; Beltramini,L.M.; Borel,I.M.; Frank,Ronald*; Tonarelli,G.G.; (2007). Systematic epitope analysis of the p26 EIAV vore protein. Journal of Molecular Recognition: 20 4, 227-237

Ebensen,Thomas*; Schulze,Kai*; Riese,Peggy*; Morr,Michael*; Guzmán,Carlos A.*; (2007). The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant. Clinical and Vaccine Immunology: 14 8, 952-958 HZI-Repositorium PubMed

Ebensen,Thomas*; Schulze,Kai*; Riese,Peggy*; Link,Claudia*; Morr,Michael*; Guzmán,Carlos A.*; (2007). The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties. Vaccine: 25 8, 1464-1469

Voigt,J.; Woestemeyer,J.; Frank,Ronald*; (2007). The chaotrope-soluble glycoprotein GP2 is a precursor of the insoluble glycoprotein framework of the Chlamydomonas cell wall. Journal of Biological Chemistry: 282 42, 30381-30392 HZI-Repositorium PubMed

Frank,Ronald*; Gerth,Klaus*; Kalesse,Markus*; Menche,Dirk*; Bilitewski,Ursula*; (2007). The chemical pipeline - a research program and infrastructure for the discovery and evaluation of new anti-infectives.: HZI Research Report 2006/2007. Jonas,Rainer; Schlender,Hannes; Braun,Manfred; (Ed.). Braunschweig : Helmholtz Centre for Infection Research GmbH (HZI), 32-43

Menche,Dirk*; Hassfeld,J.; Steinmetz,Heinrich*; Huss,M.; Wieczorek,H.; Sasse,Florian*; (2007). The first hydroxylated archazolid from the myxobacterium Cystobacter violaceus : Isolation, structural elucidation and V-ATPase inhibition. The Journal of Antibiotics: 60 5, 328-331

Schmitter,T.; Pils,S.; Sakk,V.; Frank,Ronald*; Fischer,K.-D.; Hauck,C.R.; (2007). The granulocyte receptor CEACAM3 directly associates with Vav to promote phagocytosis of human pathogens. Journal of Immunology: 178 6, 3797-3805

Boeddrich,A.; Gaumer,S.; Haacke,A.; Tzvetkov,N.; Albrecht,M.; Evert,B.O.; Müller,E.C.; Lurz,R.; Breuer,P.; Schugardt,N.; Plaßmann,S.; Xu,K.; Warrick,J.M.; Suopanki,J.; Wüllner,U.; Frank,Ronald*; Hartl,F.; Bonini,N.M.; Wanker,E.E.; (2006). An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. Embo Journal: 25 7, 1547-1558

Spadaccini,R.; Reidt,U.; Dybkov,O.; Will,C.; Frank,Ronald*; Stier,G.; Corsini,L.; Wahl,M.C.; Lührmann,R.; Sattler,M.; (2006). Biochemical and NMR analysis of a SF3b155-p14-U2AFRNA interaction network involved in branch point definition during pre-mRNA splicing. RNA: 12, 410-425 HZI-Repositorium PubMed

Berg,T.; Mayer,T.U.; Frank,Ronald*; (2006). Biochemistry and molecular biology 2005. Nachrichten aus der Chemie: 54 3, 265-270

Zhou,J.; Köhl,R.; Herr,B.; Frank,Ronald*; Brüne,B.; (2006). Calpain Mediates a von Hippel-Lindau Protein - independent Destruction of Hypoxia-inducible Factor-1alpha. Molecular Biology of the Cell: 17, 1549-1558

Montaner,A.D.; de Nichilo,A.; Elias,F.; Rogriguez,J.M.; Fló,J.M.; Lopez,R.A.; Zorzopulos,J.; Frank,Ronald*; (2006). Ganglioside GM1-binding peptides as adjuvants of antigens inocculated by the intranasal route. Vaccine: 24, 1889-1896

Zielinski,M.; Kahl,Silke*; Standfuss-Gabisch,Christine*; Camara,B.; Seeger,M.; Hofer,Bernd*; (2006). Generation of novel-substrate-accepting biphenyl dioxygenases through segmental random mutagenesis and identification of residues involved in enzyme specificity. Applied and Environmental Microbiology: 72 3, 2191-2199 HZI-Repositorium PubMed

Kader,A.; Simm,R.; Gerstel,U.; Morr,Michael*; Römling,U.; (2006). Hierachical involvement of various GGDEF domain proteins in rdar mophotype development of Salmonella enterica serovar Typhimurium. Molecular Microbiology: 60, 602-616 HZI-Repositorium PubMed

Rübenhagen,R.; Frank,Ronald*; (2006). Highly specific antibodies for use in sandwich-type antibody microarray analyses of complex biological samples. Journal of Peptide Science: 12, 100-100

Seibel,J.; Hellmuth,H.; Hofer,Bernd*; Kicinska,A.M.; Schmalbruch,B.; (2006). Identification of new acceptor specificities of glycosyltransferase R with the aid of substrate microarrays. ChemBioChem: 7, 310-320 HZI-Repositorium PubMed

Rachid,S.; Sasse,Florian*; Beyer,S.; Müller,R.; (2006). Identification of StiR, the first regulator of secondary metabolite formation in the mycobacterium Cystobacter fuscus Cb f17.1. Journal of Biotechnology: 121 4, 429-441

Khalil,M.W.; Sasse,Florian*; Lünsdorf,Heinrich*; Elnakady,Y.A.; Reichenbach,Hans*; (2006). Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria. ChemBioChem: 7, 678-683

Dikmans,A.; Beutling,U.; Schmeisser,E.; Thiele,S.; Frank,Ronald*; (2006). SC2: A novel process for manufacturing multipurpose high-density chemical microarrays. QSAR and Combinatorial Science: 25 11, 1069-1080 HZI-Repositorium

Budde,M.; Morr,Michael*; Schmid,R.D.; Urlacher,V.B.; (2006). Selective hydroxylation of highly branched fatty acids and their derivatives by CYP102A1 from Bacillus megaterium. ChemBioChem: 7, 789-794

Gory-Fauré,S.; Windscheid,V.; Bosc,C.; Peris,L.; Proietto,D.; Frank,Ronald*; Denarrier,E.; Job,D.; Andrieux,A.; (2006). STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins. Journal of Biological Chemistry: 281 38, 28387-28396

Kolberg,J.; Aase,A.; Bergmann,S.; Herstad,T.K.; Rodal,G.; Frank,Ronald*; Rohde,Manfred*; Hammerschmidt,S.; (2006). Streptococcus pneumoniae enolase is important for plasminogen binding despite low abundance of enolase protein on the bacterial cell surface. Microbiology: 152, 1307-1317

Galeyeva,Y.; Helbig,S.; Morr,Michael*; Sasse,Florian*; Nimtz,Manfred*; Laschat,S.; Baro,A.; (2006). Total synthesis and biological evaluation of (-)-pectinatone employing a methyl branched wax ester as key building block. Chemistry and Biodiversity: 3, 935-941 HZI-Repositorium PubMed

Berg,T.; Frank,Ronald*; Mayer,T.; (2006). Trendbericht Chemische Biologie im Bericht Biochemie und Molekularbiologie 2005. Nachrichten aus der Chemie: 54, 265-270

Beutling,U.; Dikmans,A.; Thiele,S.; Frank,Ronald*; (2005). A novel process for manufacturing high density multipurpose chemical micro-arrays.: Peptides 2004; Proc. 28 Europ. Peptide. Flegel; Fridkin; Gilon; Slaninova; (Ed.). Geneva : Kenes International, 152-153

Zander,N.; Beutling,U.; Dikmans,A.; Thiele,S.; Frank,Ronald*; (2005). A special cellulose membrane support for the combinatorial and parallel synthesis of peptide libraries suitable for the SC 2 -type manufacturing of high density multi-purpose chemical microarrays.: Peptides 2004; Proc. 28 Europ. Peptide. Flegel; Fridkin; Gilon; Slaninova; (Ed.). Geneva : Kenes International, 405-406

Gail,R.; Frank,R.; Wittinghofer,A.; (2005). A systematic peptide-array based delineation of differential beta-Catenin interaction with Tcf4, E-Cadherin and APC. Journal of Biological Chemistry: 280, 7107-7117

Frank,R.; Dübel,S.; (2005). Analysis of protein interactions with immobilized peptide arrays synthesized on membrane supports.: Protein-Protein Interactions, A Molecular Cloning Manual. Golemis,E.; Adams,P.; (Ed.). Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press

Huss,M.; Sasse,F.; Kunze,B.; Jansen,R.; Steinmetz,H.; Ingenhorst,G.; Zeeck,A.; Wieczorek,H.; (2005). Archazolid and apicularen: Novel specific V-ATPase inhibitors. BMC Biochemistry: 6, 13 HZI-Repositorium PubMed

Bredenbruch,F.; Nimtz,M.; Wray,V.; Morr,M.; Müller,R.; Häußler,S.; (2005). Biosynthetic pathway of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinofines. Journal of Bacteriology: 187, 3630-3635

Foley,K.F.; De Frutos,S.; Laskovski,K.; Tegge,W.; Dostmann,W.R.; (2005). Culture conditions influence uptake and intracellular localization of the membrane permeable GMP-dependent protein kinase inhibitor DT-3. Frontiers in Bioscience: 10, 1302-1312

Rübenhagen,R.; Frank,R.; (2005). Ein neuer Weg zu Antikörper-Mikroarrays mit höherer Spezifität und Selektivität. Biospektrum - Sonderausgabe: 11, 506-507

Galeyeva,Y.; Morr,M.; Laschat,S.; Baro,A.; Nimtz,M.; Sasse,F.; (2005). Ex chiral pool synthesis of (-)-siphonarienone from a methyl-branched wax ester. Synthesis: 17, 2875-2880

Deswal,R.; Singh,R.; Lynn,A.M.; Frank,R.; (2005). Identification of immunodominant regions of Brassica juncea glyoxalase I as potential antitumor immunomodulation targets. peptides: 26, 395-404

Gingras,A.R.; Ziegler,W.H.; Frank,R.; Barsukov,I.L.; Roberts,G.C.K.; Critchley,D.R.; Emsley,J.; (2005). Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod. Journal of Biological Chemistry: 280 44, 37217-37224

Bialek,K.; Swistowski,A.; Frank,R.; (2005). Peptide and protein repertoires for global analysis of modules.: Modular Protein Domains. Cesareni,G.; Gimona,M.; Sudal,M.; Yaffe,M.eds.; (Ed.). Weinheim : Wiley-VCH, 409-438

Rampon,C.; Prandini,M.-H.; Bouillot,S.; Pointu,H.; Tillet,E.; Frank,R.; Vernet,M.; Huber,P.; (2005). Protocadherin 12 (VE-cadherin) is expressed in endothelial trophoblast and mesangial cells and is dispensable for normal mouse development. Experimental Cell Research: 302, 48-60

Taylor,M.S.; Brayden,J.E.; Laskovski,K.E.; Nickl,C.K.; Tegge,Werner*; Frank,Ronald*; (2005). Specific and membrane permeable inhibitors of cGMP-dependent protein kinase.: Peptides 2004; Proc. 28 Europ. Peptide. Flegel; Fridkin; Gilon; Slaninova; (Ed.). Geneva : Kenes International, 684-685

Petri,A.F.; Sasse,F.; Maier,M.E.; (2005). Synthesis and biological evaluation of apicularen A analogues. European Journal of Organic Chemistry: 9, 1865-1875

Milkereit,G.; Gerber,S.; Brandenburg,K.; Morr,M.; Vill,V.; (2005). Synthesis and mesomorphic properties of glycosyl dialkyl- and diacyl-glycerols bearing saturated, unsaturated and methyl branched fatty acid and fatty alcohol chains. Part I. Synthesis. Chemistry and Physics of Lipids: 135, 1-14

Milkereit,G.; Brandenburg,K.; Gerber,S.; Koch,M.H.J.; Morr,M.; Andra,J.; Seydel,U.; Vill,V.; (2005). Synthesis and mesomorphic properties of glycosyl dialkyl- and diacyl-glycerols bearing saturated, unsaturated and methyl branched fatty acid and fatty alcohol chains. Part II. Mesomorphic properties. Chemistry and Physics of Lipids: 135, 15-26

Schwardt,M.; Mayer,D.; Frank,R.; Schneider,U.; Planz,O.; Wolff,T.; Schwemmle,M.; (2005). The negative regulator of Borna Disease Virus polymerase is a non-structural protein. Journal of General Virology: 86, 3163-3169

Zander,N.; Frank,R.; (2005). The use of polystyrylsulfonyl chloride resin as a solid supported condensation reagent for the formation of esters: Synthesis of N--(9-fluorenylmethoxy)carbonyl)-L-aspartic acid; "-tert-butyl ester, ß-(2-ethyl[(1E)-4-nitrophenyl)azo]phenyl]amino]ethy.: Organic Syntheses. Chichester : Wiley, 235-243

Dikmans,A.J.; Morr,M.; Zander,N.; Adler,F.; Türk,G.; Frank,R.; (2004). A new compact disc format of high density array synthesis applied to peptide nucleic acids and in situ MALDI analysis. Molecular Diversity: 8, 197-207

Papagrigoriou,E.; Gringas,A.R.; Barsukov,I.L.; Bate,N.; Fillingham,I.J.; Patel,B.; Frank,R.; Ziegler,W.H.; Roberts,G.C.K.; Critchley,D.R.; Emsley,J.; (2004). Activation of a vinculin binding site in the talin rod involves re-arrangement of a five helix bundle. Embo Journal: 23, 2942-2951

Godehardt,A.; Hammerschmidt,S.; Frank,R.; Chhatwal,G.S.; (2004). Binding of alpha 2-macroglobulin to GRAB, an important virulence factor of group A streptococci, is mediated via two charged motifs in the Delta A region. Biochemical Journal: 381, 877-885

Leibold,T.; Sasse,F.; Reichenbach,H.; Höfle,G.; (2004). Cyrmenins, novel antifungal peptides containing a nitrogen-linked ß-methoxy-acrylate pharmacophore: Isolation and structure elucidation. European Journal of Organic Chemistry: 2, 431-435

Oggero,M.; Frank,R.; Etcheverrigaray,M.; Kratje,R.; (2004). Defining the antigenic structure of human GM-CSF and its implication to receptor interaction and therapeutic treatments. Molecular Diversity: 8 3, 257-269

Bialek,K.; Swistowski,A.; Beutling,U.; Mühle,L.; Frank,R.; (2004). Development of a new biochip platform technology for the automated recognition and validation of peptide-protein-interactions.: Solid Phase Synthesis and Combinatorial Libraries. Epton,R.; (Ed.). Kingswinford, UK : Mayflower Worldwide Ltd., 35-38

Elnakady,Y.A.; Sasse,F.; Lünsdorf,H.; Reichenbach,H.; (2004). Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells. Biochemical Pharmacology: 67, 927-935

Elm,C.; Braathen,R.; Bergmann,S.; Frank,R.; Vaerman,J.-P.; Kaetzel,C.S.; Chhatwal,G.S.; Johansen,F.-E.; Hammerschmidt,S.; (2004). Ectodomains 3 and 4 of human polymeric immunoglobulin receptor (hplgR) mediate invasion of Streptococcus pneumoniae into the epithelium. Journal of Biological Chemistry: 279 8, 6296-6304

Frank,R.; (2004). Funktionelle und chemische Genomik: Kleine Moleküle kommen ganz groß raus. GenomXPress: 2, 14-15

Simm,R.; Morr,M.; Kader,A.; Nimtz,M.; Römling,U.; (2004). GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility. Molecular Microbiology: 53, 1123-1134

Eberhardt,M.O.; Frank,R.; Kratje,R.; Etcheverrigaray,M.; (2004). GM-CSF epitope analysis using a panel of monoclonal antibodies.: Biotechnological Advances and Applications in Bioconversion of Renewable Raw Materials. Jonas,R.Pandey A.Tharun G.; (Ed.). Braunschweig, Germany : Döring Druck, 250-254

Frank,R.; (2004). High-density synthetic peptide arrays. Molecular Diversity: 8, 175-176

Beutling,U.; Tegge,W.; Zander,N.; Frank,R.; (2004). High-throughout synthesis and screening without wells and walls.: Solid Phase Synthesis and Combinatorial Libraries. Epton,R.; (Ed.). Kingswinford, UK : Mayflower Worldwide Ltd., 191-194

Sandmann,A.; Sasse,F.; Müller,R.; (2004). Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity. Chemistry and Biology: 11 8, 1071-1079

Steinmetz,H.; Glaser,N.; Herdtweck,E.; Sasse,F.; Reichenbach,H.; Höfle,G.; (2004). Isolation, crystal and solution structure determination, and biosynthesis of tubulysins - powerful inhibitors of tubulin polymerization from myxobacteria. Angewandte Chemie - International Edition: 43, 4888-4892

Buss,H.; Dörrie,A.; Schmitz,L.M.; Frank,R.; Livingstone,M.; Resch,K.; Kracht,M.; (2004). Phosphorylation of serine 468 by GSK-3ß negatively regulates basal p65 NF-KB activity. Journal of Biological Chemistry: 279, 49571-49574

Zhou,J.; Schmid,T.; Frank,R.; Brüne,B.; (2004). PI3K/Akt is required for heat shock proteins to protect hypoxiainducible factor 1alpha from pVHL-independent degradation. Journal of Biological Chemistry: 279 14, 13506-13513

Zander,N.; Frank,R.; (2004). Polystyrylsulfonyl-3-nitro-1H-1,2,4-triazolide-resin: a new reagent for the anchoring of Fmoc-amino acids to membrane supports as esters by the SPOT Technique.: Solid Phase Synthesis and Combinatorial Libraries. Epton,R.; (Ed.). Kingswinford, UK : Mayflower Worldwide, 323-324

Bayle,J.; Letard,S.; Frank,R.; Dubreuil,P.; De Sepulveda,P.; (2004). Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling. Journal of Biological Chemistry: 279, 12249-12259 Volltext HZI-Repositorium

Hultschig,C.; Hecht,H.-J.; Frank,R.; (2004). Systematic delineation of a calmodulin peptide interaction. Journal of Molecular Biology: 343, 559-568

Schiller,D.; Rübenhagen,R.; Krämer,R.; Morbach,S.; (2004). The C-terminal domain of the betaine carrier BetP of Corynebacterium glutamicum is directly involved in sensing K+ as an osmotic stimulus. Biochemistry: 43 15, 5583-5591

Milkereit,G.; Morr,M.; Thiem,J.; Vill,V.; (2004). Thermotropic and lyotropic properties of long chain alkyl glycopyranosides. Chemistry and Physics of Lipids: 127, 47-63

Voigt,J.; Frank,R.; (2003). 14-3-3 proteins are constituents of the insoluble glycoprotein framework of the clamydomonas cell wall.. Plant Cell: 15 6, 1399-1413

Sasse,F.; Steinmetz,H.; Höfle,G.; Reichenbach,H.; (2003). Archazolid A, new cytotoxic macrolactones from Archangium gephyra (Myxobacteria). Journal of Antibiotics: 56 6, 520-525

Sasse,F.; Leibold,T.; Kunze,B.; Höfle,G.; Reichenbach,H.; (2003). Cyrmenins, new ß-methoxyacrylate of the respiratory chain isolated from Myxobacteria. Journal of Antibiotics: 56, 827-831

Borsutzky,S.; Fiorelli,V.; Ebensen,T.; Tripiciano,A.; Rharbaoui,F.; Scoglio,A.; Link,C.; Nappi,F.; Morr,M.; Buttó,S.; Cafaro,A.; Mühlradt,P.F.; Ensoli,B.; Guzmán,C.A.; (2003). Efficient mucosal delivery of the HIV-1 Tat protein using the synthetic lipopeptide MALP-2 as adjuvant.. European Journal of Immunology: 33, 1548-1556

Bialek,K.; Swistowski,A.; Frank,R.; (2003). Epitope-targeted proteome analysis: Towards a large-scale automated protein-protein-interaction mapping utilizing synthetic peptide arrays. Analytical and Bioanalytical Chemistry: 376 7, 1006-1013 Volltext HZI-Repositorium

Mataraza,J.M.; Briggs,M.W.; Li,Z.; Frank,R.; Sacks,D.B.; (2003). Identification and characterization of the Cdc42-binding site of IQGAP1. Biochemical and Biophysical Research Communications: 305, 315-321

Eberhardt,M.O.; Frank,R.; Kratje,R.; Etcheverrigaray,M.; (2003). Identification of two potential receptor-binding sites for hGM-CSF. Brazilian Journal of Chemical Engineering: 20, 15-20

Marcus,K.; Hultschig,C.; Frank,R.; Herberg,F.W.; Schuchhardt,J.; Seitz,H.; (2003). Innovative Forschungsansätze im NGFN Verbund "The Human Brain Proteome Projekct HBPP". GenomXPress: 4, 5-8

Scheele,U.; Alves,J.; Frank,R.; Duwel,M.; Kalthoff,C.; Ungewickell,E.J.; (2003). Molecular and functional characterization of clathrin and AP-2 binding determinants within a disordered domain of auxilin. Journal of Biological Chemistry: 278 28, 25357-25368

Zander,N.; Gerhardt,J.; Frank,R.; (2003). Polystyrylsulfonyl-3-nitro-1H-1,2,4-triazolide-resin: a new solid-supported reagent for the esterification of amino acids. Tetrahedron Letters: 44 35, 6557-6560

Köster,M.; Lykke-Andersen,S.; Elnakady,Y.A.; Gerth,K.; Washausen,P.; Höfle,G.; Sasse,F.; Kjems,J.; Hauser,H.; (2003). Ratjadones inhibit nuclear export by blocking DRM1/exportin 1. Experimental Cell Research: 286, 321-331

Höfle,G.; Glaser,N.; Karama,U.; Leibold,T.; Sasse,F.; Steinmetz,H.; (2003). Semisynthesis and degradation of the tubulin inhibitors epothilone and tubulysin. Pure and applied chemistry: 75, 167-178

Schubert,A.; Zakikhany,K.; Schreiner,M.; Frank,R.; Spellerberg,B.; Eikmanns,B.J.; Renscheid,D.J.; (2002). A fibrinogen receptor from group B Streptococcus interacts with fibrinogen by repetitive units with novel ligand-binding sites. Molecular Microbiology: 2, 557-569

Zander,N.; Dittrich,F.; Michaelis,K.; Tegge,W.; Frank,R.; (2002). A new high-performance polypropylene-based membrane support for the parallel synthesis of peptides and small organic compounds.: Peptides 2002, Proceedings 27. European Peptide Symposium. Benedetti,Ettore; Pedone,Carlo; (Ed.). Napoli : Edizioni Ziino, 340-341

Sasse,F.; Steinmetz,H.; Schupp,T.; Petersen,F.; Memmert,K.; Hofmann,H.; Heusser,C.; Brinkmann,V.; Von Matt,P.; HofleG.; Reichenbach,H.; (2002). Argyrins, immunosuppressive cyclic peptides from Myxobacteria - I. Production, isolation, physico-chemical and biological properties. Journal of Antibiotics: 55 6, 543-551

Frank,R.; (2002). Chemische Genomik: funktionelle Genomanalyse mit synthetischen Verbindungen.. BioSpektrum, Sonderausgabe "Proteomics & Drug Development":, 474-477

Zander,Norbert; Gausepohl,Heinrich; (2002). Chemistry of Fmoc peptide synthesis on membranes.: Peptide arrays on membrane supports - synthesis and applications:. Koch,Joachim; Mahler,Michael; (Ed.). Berlin : Springer-Verlag, 23-40

Morr,M.; Takeuchi,O.; Akira,S.; Simon,M.; Mühlradt,P.F.; (2002). Differential recognition of structural details of bacterial lipopeptides by toll-like receptors. European Journal of Immunology: 32, 3337-3347

Dostmann,W.R.G.; Tegge,W.; Frank,R.; Nickl,C.K.; Taylor,M.S.; Brayden,J.E.; (2002). Exploring the mechanisms of vascular smooth muscle tone with highly specific, membrane-permeable inhibitors of cyclic GMP-dependent protein kinase Ialpha. Pharmacology & Therapeutics: 93 2-3, 203-215

Frank,R.; Balling,R.; (2002). Funktionelle Genomanalyse mit synthetischen Verbindungen: das NGFN unterstützt Initiative zur Chemischen Genomik. GenomXPress: 02 3, 20-21

Billich,C.; Sauder,C.; Frank,R.; Herzog,S.; Bechter,K.; Takahashi,K.; Peters,H.; Staeheli,P.; Schwemmle,M.; (2002). High-avidity human serum antibodies recognizing linear epitopes of borna disease virus proteins. Biological Psychiatry: 51 12, 979-987 Volltext HZI-Repositorium

Frank,R.; (2002). High-density synthetic peptide microarrays: emerging tools for fuctional genomics and proteomics. Combinatorial Chemistry & High Throughput Screening: 5, 327-335

Schultz,A.; Laschat S.; Morr,M.; Diele,S.; Dreyer,M.; Bringmann,G.; (2002). Highly branched alkanoic acids from the preen-gland wax of the domestic goose as building blocks for chiral triphenylenes. Helvetica Chimica Acta: 85, 3909-3018

Frank,R.; Bialek,K.; Swistowski,A.; (2002). Large-scale protein-interaction mapping with synthetic peptide arrays: epitope-targeted proteome analysis.: Peptides 2002, Proceedings of the 27. European Peptide Symposium. Benedetti,Ettore; Pedone,Carlo; (Ed.). Napoli : Edizioni Ziino, 102-103

Niggemann,Jutta*; Michaelis,K.; Frank,Ronald*; Zander,N.; Höfle,Gerhard*; (2002). Natural product-derived building blocks for combinatorial synthesis. Part 1. Fragmentation of natural products from myxobacteria. Journal of The Chemical Society, Perkin Transactions I: 1, 2490-2503

Frank,Ronald; Schneider-Mergener,Jens; (2002). SPOT-Synthesis - Scope of applications.: Peptide Arrays on Membrane Supports - Synthesis and Application. Koch,Joachim; Mahler,Michael; (Ed.). Berlin : Springer Verlag, 1-24

Von Minden,H.M.; Morr,M.; Milkereit,G.; Heinz,E.; Vill,V.; (2002). Synthesis and mesogenic properties of glycosyl diacilglycerols. Chemistry and Physics of Lipids: 114, 55-80

Rharbaoui,F.; Drabner,B.; Borsutzky,S.; Winckler,U.; Morr,M.; Ensoli,B.; Mühlradt,P.F.; Guzmán,C.A.; (2002). The Mycoplasma-derived lipopeptide MALP-2 is a potent mucosal adjuvant.. European Journal of Immunology: 32, 2857-2865

Chevrier,V.; Piel; Collomb,N.; Saoudi,Y.; Frank,R.; Paintrand,M.; Narumiya,S.; Bornens,M.; Job,D.; (2002). The Rho-associated protein kinase p160ROCK is required for centrosome positioning.. Journal of Cellular Biology: 157 5, 807-817

Frank,R.; (2002). The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports-principles and applications. Journal of Immunological Methods: 267 1, 13-26

Adler,F.; Turk,G.Frank R.; Zander,N.; Wu,W.; Volkmer-Engert,R.; Schneider-Mergener,J.; Gausepohl,H.; (2001). A new array format for the automated parallel combinatorial synthesis by the SPOT-technique.: Solid Phase Synthesis & Combinatorial Libraries. Epton,R.; (Ed.). Birmingham : Mayflower Worldwide Ltd., 221-222

Cervoni L.; Lascu I.; Xu Y.; Gonin P.; Morr M.; Merouani M.; Janin J.; Giartosio A; (2001). Binding of nucleotides to nucleoside diphosphate kinase: a calorimetric study. Biochemistry: 40, 4583-4589 Volltext HZI-Repositorium

Takeuchi,O.; Kawai,T.; Mühlradt,P.F.; Morr,M.; Radolf,J.D.; Zychlinsky,A.; Takeda,K.; Akira,S.; (2001). Discrimination of bacterial lipoproteins by Toll-like receptor 6. International immunology: 13 7, 933-940

Morr,M.; Kakoschke,C.; Ernst,L.; (2001). Formation of phostonic acids during reduction of azidonucleosidephosphonic acids.. Tetrahedron Letters: 42, 8841-8843

Bosc,C.; Frank,R.; Schweitzer,A.; Denarier,E.; Ronjat,M.; Wehland,J.; Job,D.; (2001). Identification of novel bifunctional calmodulin-binding and microtubule-stabilizing motifs in stop proteins. Journal of Biological Chemistry: 276 33, 30904-30913

Corada,M.; Liao,F.; Lindgren,M.; Lampugnani,M.G.; Breviario,F.; Frank,R.; Müller,W.A.; Hicklin,D.J.; Bohlen,P.; Dejana,E.; (2001). Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability. Blood: 97 6, 1679-1684 Volltext HZI-Repositorium

Hultschig,C.; Baensch,M.; Kohl,J.; Frank,R.; (2001). Multiplexed affinity sorting and analysis of libraries on libraries: Applications to protein design and proteome research.: Solid Phase Synthesis & Combinatorial Libraries. Epton,R.; (Ed.). Birmingham : Mayflower Worldwide Ltd., 7-10

Hardt,I.H.; Steinmetz,H.; Gerth,K.; Sasse,F.; Reichenbach,H.; Höfle,G.; (2001). New natural epothilones from Sorangium cellulosum , strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. Journal of Natural Products: 64 7, 847-856

Pilawa,S.; Zander,N.; Frank,R.; (2001). Optimized reaction conditions for the direct esterification of protected amino acids to cellulose membrane supports by the SPOT-technique.: Solid Phase Synthesis & Combinatorial Libraries 2000. Epton,R.; (Ed.). Birmingham : Mayflower Worldwide, 337-338

Hawlisch,H.; Müller,M.; Frank,R.; Bautsch,W.; Klos,A.; Kohl,J.; (2001). Site-specific anti-C3a receptor single-chain antibodies selected by differential panning on cellulose sheets. Analytical biochemistry: 293 1, 142-145

Voigt,J.; Liebich,I.; Kiess,M.; Frank,R.; (2001). Subcellular distribution of 14-3-3 proteins in the unicellular green alga Chlamydomonas reinhardtii. European Journal of Biochemistry: 268 24, 6449-6457 HZI-Repositorium PubMed

Barzik,M.; Carl,U.D.; Schubert,W.D.; Frank,R.; Wehland,J.; Heinz,D.W.; (2001). The N-terminal domain of Homer/Vesl is a new class II EVH1 domain. Journal of Molecular Biology: 309 1, 155-169

Rübenhagen,R.; Morbach,S.; Krämer,R.; (2001). The osmoreactive betaine carrier BetP from Corynebacterium glutamicum is a sensor for cytoplasmic K+. Embo Journal: 20, 5412-5420

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21.05.2012