Helmholtz-Zentrum für Infektionsforschung

Helmholtz-Zentrum für Infektionsforschung

Publikationen von Dirk Heinz

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Storbeck,S.; Saha,S.; Krausze,J.; Klink,B.U.; Heinz,Dirk W.*; Layer,G.; (2011). Crystal Structure of the Heme d1 Biosynthesis Enzyme NirE in Complex with Its Substrate Reveals New Insights into the Catalytic Mechanism of S-Adenosyl-L-methionine-dependent Uroporphyrinogen III Methyltransferases. Journal of Biological Chemistry: 286 30, 26754-26767 HZI-Repositorium PubMed

Wilke,S.; Gröbe,Lothar*; Maffenbeier,V.; Jäger,Volker*; Gossen,M.; Josewski,J.; Duda,A.; Polle,L.; Owens,R.J.; Wirth,Dagmar*; Heinz,Dirk* W.; van den,Heuvel Joop*; Büssow,Konrad*; (2011). Streamlining homogeneous glycoprotein production for biophysical and structural applications by targeted cell line development. PLoS ONE: 6 12, e27829

de Groot,J.C.; Schluter,K.; Carius,Y.; Quedenau,C.; Vingadassalom,D.; Faix,J.; Weiss,S.M.; Reichelt,J.; Standfuss-Gabisch,C.; Lesser,C.F.; Leong,J.M.; Heinz,Dirk W.*; Büssow,Konrad*; Stradal,Theresia E.*; (2011). Structural Basis for Complex Formation between Human IRSp53 and the Translocated Intimin Receptor Tir of Enterohemorrhagic E. coli. 19 9, 1294-1306

Quade,N.; Dieckmann,M.; Haffke,M.; Heroven,A.K.; Dersch,Petra*; Heinz,Dirk W.*; (2011). Structure of the effector-binding domain of the LysR-type transcription factor RovM from Yersinia pseudotuberculosis. Acta Crystallographica Section D: Biological Crystallography: 67 Pt 2, 81-90 HZI-Repositorium PubMed

Quade,N.; Huo,L.; Rachid,S.; Heinz,Dirk W.*; Müller,Rolf*; (2011). Unusual carbon fixation gives rise to diverse polyketide extender units. Nature Chemical Biology: 8 1, 117-124

Brocker,M.J.; Schomburg,S.; Heinz,Dirk W.*; Jahn,D.; Schubert,W.D.; Moser,J.; (2010). Crystal structure of the nitrogenase-like dark operative protochlorophyllide oxidoreductase catalytic complex (ChlN/ChlB)2. Journal of Biological Chemistry: 285 35, 27336-27345

Heinz,Dirk W.*; Betzel,C.; Wilmanns,M.; (2010). Highlight: of systems and structures. Biological Chemistry: 391 7, 717-718

Ferraris,D.M.; Gherardi,E.; Di,Y.; Heinz,Dirk W.*; Niemann,H; (2010). Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InIB. Journal of Molecular Biology: 395 3, 522-532 HZI-Repositorium PubMed

Layer,G.; Reichelt,J.; Jahn,D.; Heinz,Dirk W.*; (2010). Structure and function of enzymes in heme biosynthesis. Protein Science: 19 6, 1137-1161

Klink,B.U.; Barden,S.; Heidler,T.V.; Borchers,C.; Ladwein,M.; Stradal,Theresia B.*; Rottner,Klemens*; Heinz,Dirk W.*; (2010). Structure of Shigella IpgB2 in complex with human RhoA: implications for the mechanism of bacterial guanine nucleotide exchange factor mimicry. Journal of Biological Chemistry: 285 22, 17197-17208 HZI-Repositorium PubMed

Heinemann,I.U.; Schulz,C.; Schubert,W.D.; Heinz,Dirk W.*; Wang,Y.G.; Kobayashi,Y.; Awa,Y.; Wachi,M.; Jahn,D.; Jahn,M.; (2010). Structure of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen synthase in complex with the antibiotic alaremycin. Antimicrobial Agents and Chemotherapy: 54 1, 267-272

Haffke,M.; Menzel,A.; Carius,Y.; Jahn,D.; Heinz,Dirk W.*; (2010). Structures of the nucleotide-binding domain of the human ABCB6 transporter and its complexes with nucleotides. Acta Crystallographica Section D: Biological Crystallography: 66 Pt 9, 979-987

Rand,K.; Noll,C.; Schiebel,H.M.; Kemken,D.; Dulcks,T.; Kalesse,Markus*; Heinz,Dirk W.*; Layer,G.; (2010). The oxygen-independent coproporphyrinogen III oxidase HemN utilizes harderoporphyrinogen as a reaction intermediate during conversion of coproporphyrinogen III to protoporphyrinogen IX. Biological Chemistry: 391 1, 55-63

Marin,M.; Heinz,Dirk W.*; Pieper,Dietmar H.*; Klink,B.U.; (2009). Crystal structure and catalytic mechanism of 4-methylmuconolactone methylisomerase. Journal of Biological Chemistry: 284 47, 32709-32716

Bublitz,M.; Nimtz,Manfred*; Polle,L.; Holland,C.; Heinz,Dirk W.*; Schubert,Wolf-Dieter*; (2009). Structural basis for autoinhibition and activation of Auto, a virulence-associated peptidglycan hydrolase of L. monocytogenes. Molecular Microbiology: 71 6, 1509-1522

Wiesand,U.; Sorg,I.; Amstutz,M.; Wagner,S.; van den Heuvel,Joop*; Lührs,Thorsten*; Cornelis,G.R.; Heinz,Dirk W.*; (2009). Structure of the type III secretion recognition protein YscU from Yersinia enterocolitica. Journal of Molecular Biology: 385 3, 854-866 HZI-Repositorium PubMed

Brocker,M.J.; Virus,S.; Ganskow,S.; Heathcote,P.; Heinz,Dirk W.*; Schubert,W.D.; Jahn,D.; Moser,J.; (2008). ATP-driven reduction by dark-operative protochlorophyllide oxidoreductase from Chlorobium tepidum mechanistically resembles nitrogenase catalysis. Journal of Biological Chemistry: 283 16, 10559-10567

Buettner,C.R.; Sorg,I.; Cornelis,G.R.; Heinz,D.W.; Niemann,H.H.; (2008). Structure of the Yersinia enterocolitica type III secretion translocator chaperone SycD. Journal of Molecular Biology: 375 4, 997-1012 HZI-Repositorium PubMed

Wendt,K.U.; Weiss,M.S.; Cramer,P.; Heinz,Dirk W.*; (2008). Structures and diseases. Nature Structural and Molecular Biology: 15 2, 117-120 HZI-Repositorium PubMed

Niemann,H.H.; Petoukhov,M.V.; Hartlein,M.; Moulin,M.; Gherardi,E.; Timmins,P.; Heinz,D.W.; Svergun,D.I.; (2008). X-ray and neutron small-angle scattering analysis of the complex formed by the met receptor and the Listeria monocytogenes invasion protein InlB. Journal of Molecular Biology: 377 2, 489-500 HZI-Repositorium PubMed

Hagelüken,G.; Wiehlmann,L.; Adams,T.M.; Kolmar,H.; Heinz,Dirk W.*; Tümmler,B.; Schubert,Wolf-Dieter*; (2007). Crystal structure of the electron transfer complex rubredoxin-rubredoxin reductase of Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America (PNAS): 104 30, 12276-12281 HZI-Repositorium PubMed

Wollert,T.; Pasche,Bastian*; Rochon,Maike*; Deppenmeier,S.; van den Heuvel,Joop*; Gruber,A.D.; Heinz,Dirk W.*; Lengeling,Andreas*; Schubert,Wolf-Dieter*; (2007). Extending the host range of Listeria monocytogenes by rational protein design. Cell: 129 5, 891-902

Lüer,C.; Schauer,S.; Virus,S.; Schubert,Wolf-Dieter*; Heinz,Dirk W.*; Jahn,D.; Moser,J.; (2007). Glutamate recognition and hydride transfer by Escherichia coli glutamyl-tRNA reductase. FEBS Journal: 274 17, 4609-4614 HZI-Repositorium PubMed

Niemann,H.N.; Jäger,Volker*; Butler,P.J.G.; van den Heuvel,Joop*; Schmidt,S.; Ferraris,D.; Gherardi,E.; Heinz,Dirk W.*; (2007). Structure of the human receptor tyrosine kinase met in complex with the Listeria monocytogenes Invasion Protein InlB. Cell: 130 2, 235-246 HZI-Repositorium PubMed

Wollert,Thomas*; Heinz,Dirk W.*; Schubert,Wolf-Dieter*; (2007). Thermodynamically reengineering the listerial invasion complex InIA/E-Cadherin. Proceedings of the National Academy of Sciences of the United States of America (PNAS): 104 35, 13960-13965 HZI-Repositorium PubMed

Heinz,Dirk W.*; Weiss,M.S.; Wendt,K.U.; (2006). Biomacromolecular interactions, assemblies and machines: A structural view. ChemBioChem: 7 203, 208 HZI-Repositorium PubMed

Schulze,J.O.; Masoumi,A.; Nickel,D.; Jahn,M.; Schubert,Wolf-Dieter*; Heinz,Dirk W.*; (2006). Crystal structure of a non-discriminating glutamyl-tRNA synthetase. Journal of Molecular Biology: 361, 888-897 HZI-Repositorium PubMed

Schulze,J.O.; Schubert,Wolf-Dieter*; Moser,J.; Jahn,D.; Heinz,Dirk W.*; (2006). Evolutionary relationship between initial enzymes of tetrapyrrole biosynthesis. Journal of Molecular Biology: 358, 1212-1220 HZI-Repositorium PubMed

Frese,S.; Schubert,Wolf-Dieter*; Findeis,A.C.; Marquardt,T.; Roske,Y.S.; Stradal,Theresia E.B.*; Heinz,Dirk W.*; (2006). Phosphotyrosine binding specificities of Nck1 and Nck2. Journal of Biological Chemistry: 281, 18236-18245

Frere,F.; Nentwich,M.; Gacond,S.; Heinz,Dirk W.*; Neier,R.; Frankenberg-Dinkel,N.; (2006). Probing the active site of Pseudomonas aeruginosa porphobilinogen synthase using newly developed inhibitors. Biochemistry: 45, 8243-8253

Hagelüken,G.; Adams,T.M.; Wiehlmann,L.; Widow,Ute*; Kolmar,H.; Tümmler,B.; Heinz,Dirk W.*; Schubert,Wolf-Dieter*; (2006). The crystal structure of SdsA1, an alkylsulfatase from Pseudomonas aeruginosa , defines an independent, third mechnanistic class of sulfatases. Proceedings of the National Academy of Sciences of the United States of America (PNAS): 103, 7631-7636

Layer,G.; Pierik,A.J.; Trost,M.; Jänsch,Lothar*; Leech,H.K.; Warren,M.J.; Rigby,S.E.; Astner,I.; Grage,K.; Breckau,D.; Heinz,Dirk W.*; Jahn,D.; (2006). The substrate radical of Escherichia coli oxygen-independent coproporphyrinogen III oxidase HemN. Journal of Biological Chemistry: 281, 15727-15734

Jahn,D.; Moser,J.; Schubert,Wolf-Dieter*; Heinz,Dirk W.*; (2006). Transfer RNA-dependent aminolevulinic acid formation: structure and function of glutamyl-tRNA synthase, reductase and glutamate-1-semialdehyde-2,1-aminomutase.: Chlorophylls and Bacteriochlorophylls: Biochemistry, Biophysics, Functions and Applications. Grimm,B.; Porra,R.J.; Rudiger,W.; Scheer,H.; (Ed.). Dordrecht : Springer Verlag, 159-171

Reichelt,J.; Dieterich,G.; Kvesic,M.; Schomburg,D.; Heinz,D.W.; (2005). BRAGI. Linking and visualization of database information in a 3D-viewer and modelling tool. Bioinformatics: 21, 1291-1293

Lüer,C.; Schauer,S.; Möbius,K.; Schulze,J.; Schubert,W.-D.; Heinz,D.W.; Jahn,D.; Moser,J.; (2005). Complex formation between Glutamyl-tRNA Reductase and Glutamate-1-semialdehyde-2,1-aminomutase in Escherichia coli during the initial reactions of porphyrin biosynthesis. Journal of Biological Chemistry: 280, 18568-18572

Astner,I.; Schulze,J.O.; van den Heuvel,J.; Jahn,D.; Schubert,W.-D.; Heinz,D.W.; (2005). Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans. Embo Journal: 24, 3166-3177 HZI-Repositorium

Buettner,C.; Cornelis,G.R.; Heinz,D.W.; Niemann,H.H.; (2005). Crystal structure of Yersinia enterocolitica. Protein Science: 14, 1993-2002

Heinz,D.W.; Schubert,W.-D.; Höfle,G.; (2005). Much anticipated - The bioactive conformation of epothilone and its binding to tubulin. Angewandte Chemie - International Edition: 44, 1298-1301

Heinz,D.W.; Schubert,W.-D.; (2005). Proteins in motion. Angewandte Chemie - International Edition: 44, 4428

Layer,G.; Kervio,E.; Morlock,G.; Heinz,D.W.; Jahn,D.; Retey,J.; Schubert,W.-D.; (2005). Structural and functional comparison of HemN to other radical SAM enzymes. Biological Chemistry: 386, 971-980

Eiting,M.; Hagelüken,G.; Schubert,W.-D.; Heinz,D.W.; (2005). The mutation G145S in PrfA, a key virulence regulator of Listeria monocytogenes , increases DNA-binding affinity by stabilizing the HTH-motif. Molecular Microbiology: 56 2, 433-446

Frere,F.; Reents,H.; Schubert,W.-D.; Heinz,D.W.; (2005). Tracking the evolution of porphobilinogen synthase metal dependence in vitro. Journal of Molecular Biology: 345 5, 1059-1070

Niemann,H.; Schubert,W.-D.; Heinz,D.; (2004). Adhesins and invasions of pathogenic bacteria: a structural view. Microbes and Infection: 6, 101-112

Freiberg,A.; Machner,M-P.; Pfeil,W.; Schubert,W.-D.; Heinz,D.W.; Seckler,R.; (2004). Folding and stability of the leucine-rich repeat domain of internalin B from Listeria monocytogenes. Journal of Molecular Biology: 337 2, 453-461

Dieterich,G.; Kvesic,M.; Schomburg,D.; Heinz,D.W.; Reichelt,J.; (2004). Integrating public databases into an existing protein visualization and modeling program BRAGI. Lecture Notes in Informatics: P-53, 149-156

Ehinger,S.; Schubert,W.-D.; Bergmann,S.; Hammerschmidt,S.; Heinz,D.W.; (2004). Plasmin(ogen)-binding alpha-Enolase from Streptococcus pneumoniae : crystal structure and evaluation of plasmin(ogen)-binding sites. Journal of Molecular Biology: 343, 997-1005

Layer,G.; Heinz,D.W.; Jahn,D.; Schubert,W.-D.; (2004). Structure and function of radical SAM enzymes. Current Opinion in Chemical Biology: 8, 468-476

Machner,M.P.; Frese,S.; Schubert,W.-D.; Orian-Rousseau,V.; Gherardi,E.; Wehland,J.; Niemann,H.H.; Heinz,D.W.; (2003). Aromatic amino acids at the surface of In1B are essential for host cell invasion by Lysteria monocytogenes. Molecular Microbiology: 48, 1525-1536

Schubert,W.-D.; Heinz,D.W.; (2003). Details der Wechselwirkung zwischen Bakterium und Mensch. Laborwelt: 1, 16

Heesemann,J.; Heinz,D.W.; Rüssmann,H.; Wehland,J.; Goebel,W.; Kuhn,M.; (2003). Lektionen aus der Bakterienwelt: Ausnutzung von Wirtszellprozessen durch pathogene Mikroben. Biospektrum: 9, 486-489

Schubert,W.-D.; Heinz,D.W.; (2003). Structural aspects of adhesion and invasion of host cells by the human pathogen Listeria monocytogenes. ChemBioChem: 4, 1285-1291

van den Heuvel,J.; Heinz,D.W.; (2002). "Plug and Play"-expression systems for high-quality production of recombinant proteins for structural analysis. Gene Function & Disease: 3 1/2, 33-38

Schauer,S.; Chaturvedi,S.; Randau,L.; Moser,J.; Kitabatake,M.; Lorenz,S.; Verkamp,E.; Schubert,W.-D.; Nakayashiki,T.; Murai,M.; Wall,K.; Thomann,U.; Heinz,D.W.; Inokuchi,H.; Söll,D.; Jahn,D.; (2002). Escherichia coli glutamyl-tRNA reductase: trapping the thioester intermediate.. Journal of Biological Chemistry: 247 50, 48656-48663

Heinz,D.W.; (2002). Modellsystem für Infektionen - Pathogene Bakterien auf ihrem unheilvollen Weg verfolgt. Jahreshefte der Helmholtz-Gesellschaft:, 10-11

Schubert,W.D.; Moser,J.; Schauer,S.; Heinz,D.W.; Jahn,D.; (2002). Structure and function of glutamyl-tRNA reductases, the first enzyme of tetrapyrrole biosynthesis in plants and prokaryotes. Photosynthesis Research: 74, 205-215

Moser,J.; Schubert,W.-D.; Heinz,D.W.; Jahn,D.; (2002). Structure and function of glutamyl-tRNA-reductase involved in 5-aminolevulinic acid formation. Biochemical Society Transactions: 30, 579-584

Frere,F.; Schubert,W.-D.; Neier,R.; Jahn,D.Heinz D.W.; (2002). Structure of porphobilinogen synthase from Pseudomonas aeruginosa in complex with 5-fluorolevulinic acid suggests a double Schiff base mechanism. Journal of Molecular Biology: 320, 237-247

Schubert,W.-D.; Urbanke,C.; Ziehm,T.; Beier,V.; Machner,M.P.; Domann,E.; Wehland,J.; Chakraborty,T.; Heinz,D.W.; (2002). Structure of the complex of internalin, a major invasion protein of Listeria monocytogenes with its human receptor, E-cadherin.. Cell: 111, 825-836

Heinz,D.W.; Jahn,D.; (2002). Strukturbiologie zur gerichteten Wirkstoffentwicklung. CHEManager: 11, 14

Schubert,W.D.; Göbel,G.; Diepholz,M.; Darji,A.; Kloer,D.; Hain,T.; Chakraborty,T.; Wehland,J.; Domann,E.; Heinz,D.W.; (2001). Internalins from the human pathogen Listeria monocytogenes combine three distinct folds into a contiguous internalin domain. Journal of Molecular Biology: 312 4, 783-794

Barzik,M.; Carl,U.D.; Schubert,W.D.; Frank,R.; Wehland,J.; Heinz,D.W.; (2001). The N-terminal domain of Homer/Vesl is a new class II EVH1 domain. Journal of Molecular Biology: 309 1, 155-169

Moser,J.; Schubert,W.D.; Beier,V.; Bringemeier,I.; Jahn,D.; Heinz,D.W.; (2001). V-shaped structure of glutamyl-tRNA reductase, the first enzyme of tRNA- dependent tetrapyrrole biosynthesis. Embo Journal: 20 23, 6583-6590

Barzik,M.; Schubert,W.D.; Carl,U.; Wehland,J.; Heinz,D.W.; (2000). Crystallization and preliminary X-ray analysis of the EVH1 domain of Vesl-2b. 56 7, 930-932 Volltext HZI-Repositorium

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17.05.2012