Helmholtz Zentrum für Infektionsforschung

Helmholtz Zentrum für Infektionsforschung

Publikationen

C. J. Müller, I. Gröticke, K. Hoffmann, K. Schughart and W. Löscher (2009). Differences in sensitivity to the convulsant pilocarpine in substrains and sublines of C57BL/6 mice. Genes, Brain and Behaviour: 5, 481-92.

C. Chandras, T. Weaver, M. Zouberakis, D. Smedley, K. Schughart, N. Rosenthal, J. M. Hancock, P. N. Schofield, G. Kollias, V. Aidinis (2009). Models for Financial Sustainability of Biological Databases and Resources. Database: im Druck,

B. Srivastava, P. Blazejewska, M. Heßmann, D. Bruder, R. Geffers, S. Mauel, A. D. Gruber and K. Schughart (2009). The genetic background of the host strongly influences the response to influenza A virus infections in mice. PLoS ONE: 4 (3), e4857.

Fuchs H, Gailus-Durner V, Adler T, Pimentel JA, Becker L, Bolle I, Brielmeier M, Calzada-Wack J, Dalke C, Ehrhardt N, Fasnacht N, Ferwagner B, Frischmann U, Hans W, Hölter SM, Hölzlwimmer G, Horsch M, Javaheri A, Kallnik M, Kling E, Lengger C, Maier H, Mossbrugger I, Mörth C, Naton B, Nöth U, Pasche B, Prehn C, Przemeck G, Puk O, Racz I, Rathkolb B, Rozman J, Schäble K, Schreiner R, Schrewe A, Sina C, Steinkamp R, Thiele F, Willershäuser M, Zeh R, Adamski J, Busch DH, Beckers J, Behrendt H, Daniel H, Esposito I, Favor J, Graw J, Heldmaier G, Höfler H, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Müller W, Neschen S, Ollert M, Quintanilla-Martinez L, Rosenstiel P, Schmidt J, Schreiber S, Schughart K, Schulz H, Wolf E, Wurst W, Zimmer A and M. Hrabé de Angelis (2009). The German Mouse Clinic: a platform for systemic phenotype analysis of mouse models. Curr Pharm Biotechnol.: 10, 236-243.

K. Schughart und G. Churchill (2007). 6th Annual Meeting of the Complex Trait Consortium. Mammalian Genome: 18, 683-685.

K. Schughart und H. Schlender (2007). Das Zusammenspiel der Gene. BIOspektrum, Sonderausgabe zur Biotechnica 2007: 8-10.

E. Wollscheid-Lengeling, R. Müller, R. Balling and K. Schughart (2004). Maintaining Your Immune System - One Method for Enhanced Longevity. Science Aging Knowledge Environment: 1, 2.

Rittner, K.; Schreiber, V.; Schughart, K.; Futin, N.; Ledoux, C., and Lusky, M. (2004). Studies on the Targeting of Adenoviral Vectors Carrying a Tumor-Cell Specific Peptide. Molecular Therapy: 9, 46.

K. Schughart and N. Accart (2003). Use of adenovirus vectors for functional gene analysis in the chicken chorioallantoic membrane. Biotechniques: 34, 178-183.

K. Schughart and U.B. Rasmussen (2002). Methods for the preparation and use of solvoplex: A synthetic vector for intrapulmonary gene delivery. Gene Therapy Protocols (ed. J.R. Morgan): Humana Press, Totowa, NJ, USA , 83-94.

U. Rasmussen, V. Schreiber, H. Schultz, F. Mischler, and K. Schughart (2002). Tumor cell-targeting by phage-displayed peptides. Cancer Gene Therapy: 9, 606-612.

U. Rasmussen, V. Schreiber, K. Schughart (2001). Patent application. Transgene.

J. Streicher, M.A. Donat, B. Strauss, R. Sporle, K. Schughart, G.B. Mueller (2000). Computer-based three-dimensional visualization of developmental gene expression. Nature Genetics: 25, 147-152.

Hrabé de Angelis M., Flaswinkel H., Fuchs H., Rathkolb B., Soewarto D., Marschall S., Heffner S., Pargent W., Wuensch K., Jung M., Reis A., Richter T., Alessandrini F., Jakob T., Fuchs E., Kolb H., Kremmer E., Behrendt H., Ring J., Zimmer A., Pfeffer K., Schughart K., Wolf E., and Balling R. (2000). Genome wide large scale production of mutant mice by ENU mutagenesis. Nature Genetics: 25, 444-447.

T.E. Tsang, W. Shawlot, S.J. Kinder, A. Kobayashi, K.M. Kwan, K. Schughart, A. Kania, T.M. Jessell, R.R. Behringer, P.P.L. Tam (2000). Lim1 activity is required for intermediate mesoderm differentiation in the mouse embryo. Developmental Biology: 223, 77-99.

O. Meyer, K. Schughart, H.V.J. Kolbe (2000). Multiple expression of human interferon-b can be achieved upon repeated administration of optimized pcTG90 lipoplex. Gene Therapy: 7, 1606-1611.

U. Rasmussen, K. Schughart (2000). Patent application. Transgene.

Fuchs H, Schughart K, Wolf E, Balling R, Hrabe de Angelis M (2000). Screening for dysmorphological abnormalities-a powerful tool to isolate new mouse mutants. Mammalian Genome: 11, 528-30.

K. Schughart, R. Bischoff, U.B. Rasmussen, D. Ali Hadji, F. Perraud, N. Accart, O. Boussif, N. Silvestre, Y. Cordier, A. Pavirani, M. Courtney, H.V.J. Kolbe (1999). Solvoplexes, a new type of non-viral vectors for intrapulmonary gene delivery. Human Gene Therapy: 10, 2891-2905.

K. Schughart, R. Bischoff, D. Ali Hadji, O. Boussif, F. Perraud, N. Accart, U.B. Rasmussen, A. Pavirani, N. van Rooijen, H.V.J. Kolbe (1999). Effect of liposome-encapsulated clodronate pretreatment on synthetic vector-mediated gene expression in vivo. Gene Therapy : 6, 448-453.

U. Rasmussen, M. Benchaibi, V. Meyer, Y. Schlesinger and K. Schughart (1999). Novel human gene transfer vectors: evaluation of wild type and recombinant animal adenoviruses in human-derived cells. Human Gene Therapy: 16, 2587- 2599.

Y. Wang, R. Spoerle, L. Richardson. T. Paperna, K. Schughart and U. Francke (1998). Characterization and expression pattern of the frizzled gene Fzd9, the mouse homologue of FZD9 that is deleted in Williams-Beuren syndrome. Genomics: 57, 235-248.

S. Braun, C. Jenny, C. Thiodellet, F. Perraud, M-C Claudepierre, C. Gerard, F., Langle-Rouault, K. Schughart, A. Pavirani (1998). Glucocorticoids increase gene transfer in vitro. FEBS Lett: 454, 277-282.

C. Grimm, R. Spoerle, T.E. Schmidt, I. Adler, J. Adamski, K. Schughart and J. Graw (1998). Isolation and embryonic expression of the novel mouse gene Hic1, the homologue of HIC1, a candidate gene for the Miller-Dieker syndrome. Human Molecular Genetics: 8, 697-710.

R. Spoerle and K. Schughart (1998). Paradox segmentation along inter- and intrasomitic borderlines is followed by dysmorphology of the axial skeleton in the open brain (opb) mouse mutant. Developmental Genetics: 22, 359-373.

Balling, R., Hrabe de Angelis, M., Schughart, K., Wolf, E (1998). We need more mutants: plans for a large ENU mouse mutagenesis screen. OECD Proceedings Novel systems for the study of human disease:

H. J. Geyer, K-W. Schramm, I. Scheunert, K. Schughart, J. Butters, W. Wurst, H. Greim, R. Kluge, C. E. W. Steinberg, A. Kettrup, B. Madhukar, J. R. Olson, M. A. Gallo (1997). Considerations on genetic and environmental factors that contribute to resistance or sensitivity of mammals including humans to toxicity of 2,3,7,8,-Tetrachlordibenzo-p-dioxin (TCDD) and related compounds. Ecotoxicology & Environmental Safety: 36, 213-230.

V. Knezevic, R. DeSanto, K. Schughart, U. Huffstadt, C. Chiang, K. A. Mahon and S. Mackem (1997). Hoxd12 exerts opposing effects on preaxial and postaxial chondrogenic branches in the limb and regulates sonic hedgehog. Development: 124, 4523-4536.

R. Spoerle and K. Schughart (1997). Neural tube morphogenesis. Curr. Opin. Devel. Genet. : 7, 507-512.

R. Bischoff, K. Schughart, H. Kolbe (1997). Patent application Transgene.

K. Schughart, T. Guenther, R. Spoerle and Dietz (1997). Patent Nr. DE 196 50 880 C1. Vorrichtung zur Durchfuehrung von Genexpressionsanalysen.

D. E. Cash, Bock, C. B., K. Schughart, E. Linney and M. Underhill (1997). Retinoic acid receptor alpha function in vertebrate limb skeletogenesis: A modulator of chondrogenesis. J. Cell Biol.: 346, 445-458.

R. Spoerle and K. Schughart (1997). System to identify individual somites and their derivatives in the developing mouse embryo. Developmental Dynamics: 210, 216-226.

T. Nagai, J. Aruga, S. Takada, A. P. McMahon, T. Guenther, R. Spoerle, K. Schughart and K. Mikoshiba (1997). The expression of the mouse Zic1, Zic2 and Zic3 gene suggests an essential role for Zic genes in body pattern formation. Developmental Biology: 182, 299-131.

T. Guenther, R. Spoerle and K. Schughart (1997). The open brain (opb) mutation maps to Chromsome 1. Mammalian Genome: 8, 583-585.

D. Becker, Z. Jiang, P. Knoedler, A. S. Deinhard, R. Eid, K. K. Kidd, C. S. Shashikant, F. H. Ruddle and K. Schughart (1996). Conserved regulatory element involved in the early onset of Hoxb-6 gene expression. Developmental Dynamics : 205, 73-81.

R. Spoerle, T. Guenther, M. Struwe and K. Schughart (1996). Defects in the development of dorsal spinal cord and epaxial musculature in opb mutant embryos. Ann. Anat: 178, 107-126.

R. Spoerle, T. Guenther, Struwe, M. and K. Schughart (1996). Severe defects in the formation of epaxial musculature in open brain (opb) mutant embryos. Development : 122, 76-86.

D. Becker, R. Eid and K. Schughart (1996). The limb/LPM enhancer of the murine Hoxb-6 gene: reporter gene analysis in transgenic embryos and studies of DNA-protein interactions. Pharmaceutica Acta Helvetiae: 71, 29-35.

J. Favor, R. Sandulache, A. Neuhaeuser-Klaus, W. Pretsch, B. Chatterjee, E. Senft, W. Wurst, V. Blanquet, P. Grimes, R. Spoerle and K. Schughart (1996). The mouse Pax2/1Neu mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye and kidney. Proc. Natl. Acad. Sci. USA: 93, 13870-13875.

K. Schughart, T. Guenther, Struwe, M. and R. Spoerle (1996). Using molecular anatomy to describe phenotypic defects in the mouse mutant open brain (opb). Aspects of Teratology: Eds. R. Vogel, J. FanghŠnel and J. Giebel, Tectum, Der Wissenschaftsverlag, Marburg 1996.

T. Guenther, M. Struwe, A. Aguzzi und K. Schughart (1994). open brain, a new mouse mutant with severe neural tube defects shows altered gene expression patterns in the developing spinal cord. Development: 120, 3119-3130.

R. Eid, H. Koseki und K. Schughart (1993). Analysis of LacZ reporter genes in transgenic embryos suggests the presence of several cis-acting elements in the murine Hoxb-6 gene. Developmental Dynamics: 196, 205-216.

C. Kappen, K. Schughart und F.H. Ruddle (1993). Early evolutionary origin of major homeodomain sequence classes. Genomics: 18, 54-70.

K. Schughart, C.J. Bieberich, R. Eid und F.H. Ruddle (1991). A regulatory region from the mouse Hox-2.2 promoter directs gene expression into developing limbs. Development: 112, 807-811.

G. W. Byrne, C. Kappen, K. Schughart, M. Utset, L. Bogarad und F. H. Ruddle (1991). Analysis of regulatory genes using the transgenic mouse system. Biotechnology: 16, 135-152.

C.S. Sashikant, M. F. Utset, S.M. Violette, T.L. Wise, P. Einat, M. Einat, J.W. Pendleton, K.Schughart und F.H. Ruddle (1990). Homeobox genes in mouse Development. CRC Critical Reviews in Eucaryotic Gene Expression: 207-245.

J. Malicki, K. Schughart und W. McGinnis (1990). Mouse Hox-2.2 specifies thoracic segmental identity in Drosophila embryos and larvae. Cell: 63, 961-967.

K. Schughart, C. Kappen und F.H. Ruddle (1989). Duplication of large genomic regions during the evolution of vertebrate homeobox genes. PNAS: 86, 7067-7071.

K. Schughart, M. F. Utset, A. Feinberg, L. D. Bogarad und F. H. Ruddle (1989). Homeobox-containing genes: implications for pattern formation during embryonic development in the mous. Genetics of neuropsychiatric diseases: 295-306.

K. Schughart, D. Pravtcheva, M. S. Newman, L. W. Hunahan, Z. Jiang und F. H. Ruddle (1989). Isolation and regional localization of the murine homeobox-containing gene Hox-3.3 to mouse chromosome region 15E. Genomics: 5, 76-83.

C. Kappen, K. Schughart und F.H. Ruddle (1989). Mammalian Antennapedia-class homeobox genes: organization, expression and evolution. Molecular genetics of early Drosophila and mouse development:

K. Schughart, C. Kappen und F.H. Ruddle (1989). Murine homeobox genes: genome organization, structure, expression and evolution. British Journal of Cancer: 58 Suppl. IX, 9-13.

C. Kappen, K. Schughart und F. H. Ruddle (1989). Organization and expression of homeobox genes in mouse and man. Viral Oncogenesis and cell differentiation: The contributions of Charlotte Friend: Ann. Acad. Sci. 567, 243-252.

C. Kappen, K. Schughart und F.H. Ruddle (1989). Two steps in the evolution of Antennapedia-class vertebrate homeobox genes. PNAS: 86, 5459-5463.

K. Schughart, M. F. Utset, A. Awgulewitsch und F. H. Ruddle (1988). Structure and expression of Hox-2.2, a murine homeobox-containing gene. PNAS: 85, 5582-5586.

K. Schughart, B. von Wilcken-Bergmann und H. Esche (1987). Expression of adenovirus type 12 E1b 58-kDa protein in Escherichia coli and production of antibodies against a 58-kDa::-galactosidase fusion protein. Gene: 53, 173-180.

K. Schughart, E. Bause und H. Esche (1985). Structure and expression of adenovirus type 12 E1B 58K protein in infected and transformed cells: studies using antibodies directed against a synthetic peptide. Virus Research: 3, 41-56.

H. Esche, M. Reuther und K. Schughart (1984). Early and late proteins of adenovirus type 12: translation mapping with RNA isolated from infected and transformed cells. Current Topics in Microbiology and Immunology: 111, 91-106.

W. Kramer, K. Schughart und H.-J. Fritz (1982). Directed mutagenesis of DNA cloned in filamentous phage: influence of hemimethylated GATC sites on marker recovery from restriction fragments. Nucleic Acids Research: 10, 6475-6485.

10.03.2010

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