Helmholtz-Zentrum für Infektionsforschung

Helmholtz-Zentrum für Infektionsforschung

Publikationen der Arbeitsgruppe

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Smith AJ, Dai H, Correia C, Takahashi R, Lee SH, Schmitz I, Kaufmann SH.; (2011). Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells.. J Biol Chem: 286(20), 17682-17692 PubMed

Brandt,S.; Ellwanger,K.; Beuter-Gunia,C.; Schuster,M.; Hausser,A.; Schmitz,Ingo*; Beer-Hammer,S.; (2010). SLy2 targets the nuclear SAP30/HDAC1 complex. International Journal of Biochemistry and Cell Biology: 42 9, 1472-1481

Emadi,Baygi M.; Soheili,Z.S.; Schmitz,Ingo*; Sameie,S.; Schulz,W.A.; (2010). Snail regulates cell survival and inhibits cellular senescence in human metastatic prostate cancer cell lines. Cell Biology and Toxicology: 26 6, 553-567 HZI-Repositorium PubMed

Ueffing N, Singh KK, Christians A, Thorns C, Feller AC, Nagl F, Fend F, Heikaus S, Marx A, Zotz RB, Brade J, Schulz WA, Schulze-Osthoff K, Schmitz I*, Schwerk C; (2009). A SNP in the cellular FLICE-inhibitory protein (c-FLIP) gene determines protein isoform production and is associated with risk of follicular lymphoma in humans. Blood:

Vogler M, Weber K, Dinsdale D, Schmitz I, Schulze-Osthoff K, Dyer MJS, Cohen GM ; (2009). Different forms of cell death induced by putative BCL2 inhibitors. Cell Death Differ: 16(7), 1030-1039 PubMed

Mersmann J, Zacharowski PA, Schmitz I, Zacharowski K; (2008). Caspase inhibitors zVAD.fmk and Q-VD-OPh fail to reduce infarct size after myocardial ischaemia and reperfusion in rodents. Resuscitation: 79(3), 468-474 PubMed

Hippe D, Lytovchenko O, Schmitz I, Lüder CGK ; (2008). Fas/CD95-mediated apoptosis of type II cells is blocked by Toxoplasma gondii primarily via interference with the mitochondrial amplification loop. Infect Immun: 76(7), 2905-2912 PubMed

Feyen O, Telieps T, Schmitz I, Niehues T ; (2008). Impaired CD95-mediated apoptosis in autoimmunity and occurrence of a p22 caspase-8 cleavage product in JIA. Klin. Pädiatrie: 220(6), 358-364 PubMed

Ueffing N, Keil E, Freund C, Kühne R, Schulze-Osthoff K, Schmitz I; (2008). Structural and mutational analyses of c-FLIPR, the only murine short FLIP isoform, reveal requirements for DISC recruitment. Cell Death and Differ: 15(4), 773-782 PubMed

Knobloch J, Schmitz I, Götz K, Schulze-Osthoff K, Rüther U; (2008). Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression and stimulation of caspase-dependent cell death. Mol Cell Biol: (2), 529-538 PubMed

Ueffing N, Schuster M, Keil E, Schulze-Osthoff K, Schmitz I; (2008). Upregulation of c-FLIPshort by NFAT contributes to apoptosis resistance of short-term activated T cells. Blood: 112(3), 690-698 PubMed

Samraj AK, Sohn D, Schulze-Osthoff K, Schmitz I; (2007). Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization. Mol Biol Cell: 18(1), 84-93 PubMed

Vutova P, Wirth M, Hippe D, Gross U, Schulze-Osthoff K, Schmitz I, and Lüder CGK ; (2007). Toxoplasma gondii inhibits Fas/CD95-triggered cell death by inducing aberrant processing and degradation of caspase 8. Cell Microbiol: 9(6), 1556-1570 PubMed

Troeger T, Schmitz I, Siepermann M, Glouchkova L, Gerdemann U, Janka-Schaub GE, Schulze-Osthoff K, Dilloo D; (2007). Upregulation of c-FLIPS+R upon CD40-stimulation is associated with inhibition of CD95-induced apoptosis in primary precursor B-ALL. Blood: 110(1), 384-387 PubMed

Schmitz I, Meyer C, Schulze-Osthoff K; (2006). CD95 ligand mediates T-cell receptor-induced apoptosis of a CD4+ CD8+ double positive thymic lymphoma. Oncogene: 25(58), 7587-7596 PubMed

Samraj AK, Keil E, Ueffing N, Schulze-Osthoff K, Schmitz I; (2006). Loss of caspase-9 provides genetic evidence for the type I/II concept of CD95-mediated apoptosis. J Biol Chem: 281(40), 29652-29659 PubMed

Golks A, Brenner D, Schmitz I, Watzl C, Krueger A, Krammer PH, Lavrik I; (2006). The role of CAP3 in CD95 signaling: new insights into the mechanism of procaspase-8 activation. Cell Death and Diff: 13(3), 489-498 PubMed

Siegmund D, Wiscovsky A, Schmitz I, Schulze-Osthoff K, Kreuz S, Leverkus M, Dittrich-Breiholz O, Kracht M, Wajant H; (2005). Death receptor-induced signaling pathways were differentially regulated by Interferon-g upstream of caspase-8 processing. Mol Cell Biol: 25(15), 6363-6379 PubMed

Schmitz I, Weyd H, Krueger A, Baumann S, Fas SC, Krammer PH, Kirchhoff S; (2004). Resistance of activated T cells towards CD95-mediated apoptosis is dependent on de novo protein synthesis. J Immunol: 172(4), 2194-2000

Schmitz I, Clayton LK, Reinherz EL ; (2003). Gene expression analysis of thymocyte selection in vivo. Int Immunol: 15(10), 1237-1248 PubMed

Lavrik I, Krueger A, Schmitz I, Baumann, S, Weyd H, Krammer PH, Kirchhoff S; (2003). Letter to the Editor: Active caspase-8 tetramer is formed at the CD95 DISC. Cell Death and Diff: 10(1), 144-145 PubMed

Schmitz I*, Krueger A*, Baumann S, Krammer PH, Kirchhoff S; (2003). Primary Human T cells Switch from CD95-Type II to CD95-Type I cells in an IL-2 Dependent Manner. J Immunol: 171(6), 2930-2936 PubMed

Schmitz I, Krueger A, Baumann S, Krammer PH, Kirchhoff S; (2002). Detection of human CD95 by different antibodies. Biochem Biophys Res Commun: 297(3), 459-462 PubMed

Hentze H*, Schmitz I*, Latta M, Krueger A, Krammer PH, Wendel A; (2002). Glutathione dependency of caspase-8 activation at the death-inducing signaling complex (DISC). J Biol Chem: 277(7), 5588-5595 PubMed

Fiorini E, Schmitz I, Marissen WE, Osborn SL, Touma M, Sasada T, Reche PA, Tibaldi E, Kruisbeek AM, Reinherz EL, Clayton LK ; (2002). Peptide-induced negative selection of thymocytes activates transcription of a novel NF-kB Inhibitor protein. Mol Cell: 9(3), 637-648 PubMed

Eckhart,L.; Santos-Beneit,A.M.; Schmitz,I.; Krueger,A.; Fischer,H.; Bach,J.; Ban,J.; Kirchhoff,S.; Krammer,P.H.; Mollinedo,F.; Tschachler,E.; (2001). Alternative splicing of caspase-8 mRNA during differentiation of human leukocytes. Biochemical and Biophysical Research Communications: 289, 777-781

Krueger A, Schmitz I, Baumann S, Krammer PH, Kirchhoff S; (2001). Cellular FLICE-inhibitory protein splice variants inhibit different steps of caspase-8 activation at the CD95 death-inducing signaling complex. J Biol Chem: 276(23), 20632-20640 PubMed

Chatterjee,D.; Schmitz,I.; Yeung,K.; Krueger,A.; Kirchhoff,S.; Krammer,P.H.; Peter,M.E.; Wyche,H.; Pantazis,P.; (2001). Induction of apoptosis in 9-nitrocampthothecin-treated DU145 human prostate carcinoma cells is increased by de novo synthesis of CD95/Cd95L and downregulation of c-FLIPshort. Cancer Research: 61, 7148-7154 Volltext HZI-Repositorium

Sartorius U, Schmitz I, Krammer PH ; (2001). Molecular mechanisms of death receptor-mediated apoptosis. ChemBioChem: 2(1), 20-29 PubMed

Holmström TH, Schmitz I, Johnson VL, Krammer PH, Chow SC, Eriksson JE; (2000). Mitogen-activated protein kinase (MAPK) signaling inhibits CD95 (Fas/APO-1)-mediated apoptosis in activated T-cells:impaired cleavage of Bid and caspase-8. EMBO J: 19(20), 5418-5428

Schmitz,I.; Kirchhoff,S.; Krammer,P.H.; (2000). Regulation of death receptor-mediated apoptosis pathway. Journal of Biochemistry and Cell Biology: 32, 1123-1136

Kirchhoff,S.; Müller,W.W.; Krueger,A.; Schmitz,I.; Krammer,P.H.; (2000). TCR-mediated Up-regulation of c-FLIP short correlates with resistance towards CD95-mediated apoptosis. Journal of Immunology: 165, 6293-6300

Schmitz I, Walczak H, Krammer PH, Peter ME ; (2000). The two CD95 apoptosis signaling pathways may be a way of cells to respond to different amounts and/or forms of CD95 ligand produced in different tissues. Cell Death and Differ: 7(8), 756-758

Scaffidi C*, Schmitz I*, Zha J, Korsmeyer SJ, Krammer PH, Peter ME ; (1999). Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J Biol Chem: 274(32), 22532-22538 PubMed

Keppler OT, Peter ME, Hinderlich S, Moldenhauer G, Stehling P, Schmitz I, Schwartz-Albiez R, Reutter W, Pawlita M; (1999). Differential sialylation of cell surface glycoconjugates in a human B lymphoma cell line regulates susceptibility for CD95 (APO-1/Fas)-mediated apoptosis and for infection by a lymphotropic virus. Glycobiology: 9(6), 557-569 PubMed

Schmitz I, Walczak H, Krammer PH, Peter ME ; (1999). Letter to the Editor: Differences between CD95 type I and type II cells detected with the CD95 ligand. Cell Death and Diff: 6(9), 821-822 PubMed

Scaffidi C*, Schmitz I*, Krammer PH, Peter ME; (1999). The role of c-FLIP in modulation of CD95-induced apoptosis. J Biol Chem.: 274(3), 1541-1548 PubMed

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17.05.2012