Publications

1. Pherotypes are driving genetic differentiation within Streptococcus pneumoniae. M. Carrolo, F.R. Pinto, J. Melo-Cristino, M. Ramirez. BMC Cicrobiology, 2009, 9: 191.
2. Crystallization and preliminary crystallographic analysis of the catalytic module of endolysin from Cp-7, phage infecting Streptococcus pneumoniae. N. Silva-Martin, R. Molina, I. Angulo, J.M. Mancheno, P. García, J.A. Hermoso. Acta Crystallographica, 2010, F66: 670-673.
3. Pneumococcal CbpD is a murein hydrolase that requires a dula cell envelope binding specificity to kill target cells during fractricide. V. Eldholm, O. Johnsborg, D. Straume, H.S. Ohnstad, K.H. Berg, JA. Hermoso, LS. Havarstein. Molecular Microbiology, 2010, 76: 905-917.
4. Crystallization of the pneumococcal autolysin LytC: in-house phasing using novel lanthanide complexes. I. Pérez-Dorado, R. Sanles, A. González, P. García, J.L. García, M. Martínez-Ripoll, J.A. Hermoso. Acta Crystallographica, 2010, F66: 448-451.
5. Serotypes 1, 7F and 19A became the leading causes of pediatric invasive pneumococcal infections in portugal after 7 years of heptavalent conjugate vaccine use. S. I. Aguiar, M. J. Brito, J. G.oncalo-Marques, J. Melo-Cristino, M. Ramirez. Vaccine, 2010, 28: 5167-5173.
6. Novel plasmid-based genetic tools for the study of promotors and terminators in Streptococcus pneumoniae and Enterococcus faecalis. S. Ruiz-Cruz, V. Solano-Collado, M. Espinosa, A. Bravo. Journal of Microbiological Methods, 2010, 83: 156-63.
7. The CXC chemokine-degrading protease SpyCep of Streptococcus pyogenes promotes its uptake into endothelial cells. S.J. Kaur, A. Nerlich, S. Bergmann, M. Rohde, M. Fulde, D. Zähner, E. Hanski, A. Zinkernagel, V. Nizet, G.S. Chhatwal, S. R. Talay. Journal of Biological Chemistry, 2010, 285: 27798-27805. 
8. PavB is a surface exposed adhesin of Streptococcus pneumoniae contributing to nasopharyngeal colonization and airways infection. I. Jensch, G. Gámez, M. Rohde, S. Ebert, M. Fulde, D. Somplatzki, S. Bergmann, M. Rohde, R. Nau, S. Hammerschmidt. Molecular Microbiology, 2010, 77(1): 22-42. 
9. Expansion and evolution of the Streptococcus pneumoniae strain 9V-ST156 clonal complex in Poland. E. Sadowy, A. Kuch, M. Gniadkowski, W. Hryniewicz. Antimicrobial Agents and Chemotherapy, 2010, 54(5): 1720-1727.
10. Insights into pneumococcal fratricide from the crystal structures of the modular killing factor LytC. I. Pérez-Dorado, A. González, M. Morales, R. Sanles, W. Striker, W. Vollmer, S. Mobashery, J. L. García, M. Martinez-Ripoll, P. García, J.A. Hermoso. Nature Structural and Molecular Biology, 2010,  17: 576-581. 
11. TLR2- and nukleotide-binding oligomerization domain2-dependent Kruppel-like factor 2 expression downregulates NF-kappaB-related gene expression. J. Zahlten, R. Steinicke, B. Opitz, J. Eitel, P. D. N´Guessan, M. Vinzing, M. Witzenrath, B. Schmeck, S. Hammerschmidt, N. Suttorp, S. Hippenstiel. Journal of Immunology, 2010, 185: 597-604. 
12. Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia. S. Ribes, S. Ebert, T. Regen, A. Agarwal, S.C. Tauber, D. Czesnik, A. Spreer, S. Bunkowski, H. Eiffert, U.-K. Hanisch, S. Hammerschmidt, R. Nau. Infection and Immunity, 2010, 78(2): 865-871.
13. Genomic organization, structure, regulation and pathogenic role of pilus constituents in major pathogenic streptococci and enterococci. B. Kreikemeyer, B. Gamez, I. Margarit, J.C. Giard, S. Hammerschmidt, A. Hartke, A. Podbielski. International Journal of Medical Microbiology, 2010, 301(3): 240-251.
14. Polymeric immunoglobulin receptor-mediated invasion of Streptococcus pneumoniae into host cells requires a coordinate signaling of SRC family of protein-tyrosine kinases, ERK, and c-Jun N-terminal kinase. V. Agarwal, T.M. Asmat, N.I. Dierdorf, C.R. Hauck, S. Hammerschmidt. Journal of Biological Chemistry, 2010, 285: 35615-35623.
15. The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells. S. Ribes, N. Adam, S. Ebert, T. Regen, S. Bunkowski, U.K. Hanisch, R. Nau. Neurosci Lett, 2010, 482: 17-20. 
16. Penetration of drugs for the treatment of central nervous system infections through the blood-cerebrospinal fluid and blood-brain barrier. R. Nau, F. Sorgel, H. Eiffert. Clin Microbiol Rev, 2011, 23: 858-883.
17. Structural autonomy of a beta-hairpin peptide derived from the pneumococcal choline-binding protein LytA. B. Maestro, C.M. Santiveri, M.A. Jimenez, J.M. Sanz. Protein Eng Des Sel, 2011, 24: 113-122.
18. Recognition of peptidoglycan and beta-lactam antibiotics by the extracellular domain of the Ser/Thr protein kinase StkP from Streptococcus pneumoniae. B. Maestro, L. Novakova, D. Hesek, M. Lee, E. Leyva, S. Monbashery, J.M. Sanz, P. Branny. FEBS Lett, 2011, 585: 357-363.
19. Crystallization and preliminary X-ray diffraction analysis of lytic transglycosylase MltE from Escherichia coli. C. Artola-Recolons, L. Llarrull, E. Lastochkin, S. Mobashery, J.A. Hermoso. Acta Crystallographica, 2011, F67: 161-163.
20. Streptococcus pneumoniae infection of host epithelial cells via polymeric immunoglobulin receptor transiently induces calcium release from intracellular stores. T.M. Asmat, V. Agarwal, S. Rath, J.P. Hildebrandt, S. Hammerschmidt. J Biol Chem, 2011, Epub 2011 March 29.
21. Impact of glutamine transporters on pneumococcal fitness under infection related conditions. T. Hartel, M. Klein, U. Koedel, M. Rohde, L. Petruschka, S. Hammerschmidt. Infect Immun, 2011, 79(1): 44-58.
22. Choline dendrimers as generic scaffolds for the non-covalent synthesis of multivalent protein assemblies. V.M. Hernández-Rocamora, S.W. Reulen, B. de Waal, E.W. Meijer, J.M. Sanz, M. Merkx. Chem Commun (Camb), 2011, 47: 5997-5999.
23. New alkaloid antibiotics that target the DNA topoisomerase I of Streptococcus pneumoniae. T. García, M.A. Blázquez, M.J. Ferrándiz, M.J. Sanz, N. Silva-Martín, J.A. Hermoso, A.G. de la Campa. J Biol Chem, 2011, 286: 6402-6413.
24. Genetic regulation of the yefM-yoeB toxin-antitoxin locus of Streptococcus pneumoniae. W.T. Chan, C. Nieto, J.A. Harikrishna, SK Khoo, R.Y. Othman, M. Espinosa. J Bacteriol, 2011, 193: 4612-4625.
25. Serotype changes in adult invasive pneumococcal infections in Portugal did not reduce the high fraction of potentially vaccine preventable infections.  A.N. Horácio, J. Diamantino-Miranda, Sandra I. Aguiar, Mário Ramirez, José Melo-Cristino. Vaccine, 2011
26. Heterologous expresion of pneumococcal virulence factor PspC on the surface of Lactococcus lactis onfers adhesive properties. T.M. Asmat, K. Klingbeil, I. Jensch, G. Burchhardt, S. Hammerschmidt. Microbiology, 2012, Jan 5 (Epub ahead of print).
27. Combat pneumococcal infections: adhesins as candidates for protein-based vaccine development. G. Gamez, S. Hammerschmidt. Curr Drug Targets, 2012, Dec 29 (Epub ahead of print).
28. Characterization of the central carbon metabolism of Streptococcus pneumoniae by isotopologue profiling. T. Haertel, E. Eylert, C. Schul, L. Petruschka, P. Gierok, S. Grubmueller, M. Lalk, W. Eisenreich, S. Hammerschmidt. J Biol Chem, 2012, 287: 4260-4274.
29. Streptococcus pneumoniae induces exocytosis of Weibel-Palade bodies in pulmonary endothelial cells. M. Luettge, M. Fulde, S.R. Talay, A. Nerlich, M. Rohde, K.T. Preissner, S. Hammerschmidt, M. Steinert, T.J. Mitchell, G.S. Chhatwal, S. Bergmann. Cell Microbiol, 2011, Oct 14 (Epub ahead of print)
30. Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 and Streptococcus pneumoniae R6 by microglial cells. S. Redlich , S. Ribes , S. Schütze, D. Czesnik, R. Nau.  J Neuroimmunol, 2012, Jan 11. (Epub ahead of print)

31. Overtone's rule helps to estimate the penetration of anti-infectives into patients' cerebrospinal fluid. M. Djukic, M. Munz, F. Sörgel, U. Holzgrabe, H. Eiffert, R. Nau. Antimicrob Agents Chemother, 2012, 56: 979-88.

32. Intrathecal treatment with the antiphosphorylcholine monoclonal antibody TEPC-15 decreases neuronal damage in experimental pneumococcal meningitis. J. Gerber, S. Redlich, S. Ribes, S.C. Tauber, H. Schmidt, R. Nau. Chemotherapy, in print

33. Fibronectin stimulates Escherichia coli phagocytosis by microglial cells. S. Ribes, S. Ebert, T. Regen, D. Czesnik, J. Scheffel, A. Zeug, S. Bunkowski, H. Eiffert, U. K. Hanisch, S. Hammerschmidt, R. Nau. Glia, 2010, 58: 367-76.

34. First report of Streptococcus pneumoniae serotype 6d isolates from invasive infections. A. Kuch, E. Sadowy, A. Skoczynska, W. Hryniewicz. Vaccine, 2010, 28: 6406-7.

35. The current status of invasive pneumococcal disease in Poland. A. Skoczynska, E. Sadowy, K. Bojarska, J. Strzelecki, A. Kuch, A. Golebiewska, I. Wasko, M. Forys, M. van der Linden, W. Hryniewicz. Vaccine, 2011, 29: 2199-205.

36. The relBE2Spn toxin-antitoxin system of Streptococcus pneumoniae: role in antibiotic tolerance and functional conservation in clinical isolates. C. Nieto, E. Sadowy, A. G. de la Campa, W. Hryniewicz, M. Espinosa. PLoS One, 2010, e11289.

37. Large-scale filter mating assay for intra- and inter-specific conjugal transfer of the promiscuous plasmid pMV158 in Gram-positive bacteria. F. Lorenzo-Diaz and M. Espinosa. Plasmid, 2009, 61: 65-70.

38. Lagging-strand DNA replication origins are required for conjugal transfer of the promiscuous plasmid pMV158. F. Lorenzo-Diaz and M. Espinosa. J Bacteriol, 2009, 191: 720-727.

39. Plasmid pSM19035, a model to study stable maintenance in Firmicutes. V.S. Lioy, F. Pratto, A.B. de la Hoz, S. Ayora, and J.C. Alonso. Plasmid, 2010, 64: 1-17.

40. A toxin-antitoxin module as a target for antimicrobial development. V.S. Lioy, O. Rey, D. Balsa, T. Pellicer, and J.C. Alonso. Plasmid, 2010, 63: 31-39.

41. The MobM relaxase domain of plasmid pMV158: thermal stability and activity upon Mn2+ and specific DNA binding. F. Lorenzo-Diaz, L. Dostal, M. Coll, J.F. Schildbach, M. Menendez, M. Espinosa. Nucleic Acids Research, 2011, 39: 4315-29.

42. Construction of a plasmid vector based on the pMV158 replicon for cloning and inducible gene expression in Streptococcus pneumoniae. J.A. Ruiz-Maso, C. Lopez-Aguilar, C. Nieto, M. Sanz, P. Buron, M. Espinosa, G. del Solar. Plasmid, 2012, 67: 53-59.

43. The zeta toxin induces a set of protective responses and dormancy. V.S. Lioy, C. Machon, M. Tabone, J.E. Gonzalez-Pastor, R. Daugelavicius, S. Ayora, and J.C. Alonso. PLos One, 2012, 7: e30282.

44. Auto-regulation of the synthesis of the MobM relaxase encoded by the promiscuous plasmid pMV158. F. Lorenzo-Diaz, V. Solano-Collado, R. Lurz, A. Bravo, M. Espinosa. J Bacteriol, 2012, in press

45. Frequency of serotype 19A pneumococci in acute otititis media in an Argentinian pediatric hospital before the introduction of conjugated-vaccines in the national calendar. V. Reijtman, P. Sommerfleck, P. Bernáldez, C. Hernández, M. Litterio, S. Fossati, M. Regueira, H. Lopardo. Medicina Infantil, 2011, 18: 323-327