08.01.2013, 17:00 - Talk - Wissenschaftlich

Colin Fishwick "An in silico fragment-based approach to anti-infective drug discovery"

09.01.2013, 17:15 - HZI Colloquium - Wissenschaftlich

Peter Kämpfer "Taxonomy of Streptomyces - Problems and Challenges"

The genus Streptomyces comprises now around 600 species and 40 subspecies (with validated names). Many of these species were described based on morphological and physiological / biochemical tests and their ability to produce secondary metabolites. The genus Streptomyces may be regarded as „overclassified“ or “underclassified”. Because of the large and very flexible genomes of Streptomyces strains it is at present very difficult to identify Streptomyces species and subspecies as there are only limited data sets provided with the original descriptions. Genomics and phylogenomics may help in the future to elucidate the taxonomic (phylogenetic) structure of the genus, however, they will also bring new questions and challenges for the taxonomy of prokaryotes in general.

16.01.2013, 17:15 - Talk - Wissenschaftlich

Lars Rogge "Multi-parameter single-cell profiling of human regulatory T cell populations"

CD4+FOXP3+ regulatory T cells (Treg) are of critical importance for the control of immune homeostasis and the maintenance of tolerance. The perspective to harness the potent immunosuppressive activity of Treg for clinical applications has sparked enormous interest in this cell population. Recent studies, however, have shown that the human Treg landscape may be more complicated than previously thought: not only do several distinct Treg subsets exist, but also the possibility has been raised that Treg may represent a “plastic” lineage with propensity to convert into an inflammatory cell phenotype. Understanding the heterogeneity of human Treg and their potential for lineage reprogramming to pro-inflammatory effector T cells is key for moving Treg therapy into the clinics. We have explored the heterogeneity and functional diversity of human Treg using multi-parameter single-cell analysis techniques in healthy donors and in patients developing acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Our data suggest that heterogeneity at the single-cell level, rather than reprogramming of CD4+FOXP3+ T cells, explains the remarkable complexity and functional diversity of human Treg.

26.01.2013, 15:00 - Talk - Öffentlich

Ausstellung zum Fotowettbewerb "INFEKTIÖS" - öffentliche Führungen

31.01.2013, 19:30 - Talk - Öffentlich

Tatsachen? Forschung unter der Lupe: „Verlust der Nacht - Die Nacht wird stetig heller"

Licht assoziieren wir mit positiven Werten wie Sicherheit und Wohlstand. Wir beleuchten nicht nur unsere Straßen, sondern setzen auch Gebäude und Denkmäler durch Licht in Szene. Doch das Zuviel an künstlichem Licht hat Auswirkungen auf Mensch und Umwelt. Der nächtliche Himmel Deutschlands wird von Jahr zu Jahr stetig heller. Durch künstliche Lichtquellen werden Tiere in ihrem Verhalten und ihrer Orientierung gestört und auch der menschliche Biorhythmus folgt dem Licht. Gemeinsam mit Ihnen und unseren Expertinnen und Experten möchten wir die ökologischen, gesundheitlichen sowie kulturellen und sozioökonomischen Auswirkungen der zunehmenden nächtlichen Beleuchtung diskutieren. Sind wir als Gesellschaft zu Veränderungen bereit, um die Dunkelheit zu wahren?